Investigating the adoption of open innovation in the bio‐pharmaceutical industry: A framework and an empirical analysis

– The purpose of this paper is to focus on the adoption of the open innovation paradigm in the bio‐pharmaceutical industry and investigate through which organisational modes (e.g. collaborations, in‐ and out‐licensing) open innovation has been implemented and how these modes are interwoven with the different phases of the drug discovery and development process. Open innovation is currently one of the most debated issues in management literature. Few contributions, however, have paid attention so far to systematically and longitudinally addressing the adoption of open innovation in a specific industry., – A two‐step research strategy has been adopted. First, a panel study of top industry representatives was organised to operationalise the concept of organisational modes of open innovation in the bio‐pharmaceutical industry. Second, the open innovation modes used by the first 20 pharmaceutical biotech firms worldwide have been documented over the period 2000‐2005 in the various phases of the drug discovery and development process., – A framework of analysis, establishing the relations between open innovation modes and the phases of the drug discovery and development process, has been developed and assessed in the industry, allowing the determinants of adoption of different modes and their managerial implications to be discussed and to relate them to the peculiarities of the biotech industry., – The paper contributes to the ongoing debate on open innovation by representing one of the first attempts to systematically and longitudinally assess the extent and particularly the determinants of the adoption of open innovation in a specific industry.

[1]  W. Powell,et al.  Interorganizational Collaboration and the Locus of Innovation: Networks of Learning in Biotechnology. , 1996 .

[2]  Barry L. Bayus,et al.  Are Product Life Cycles Really Getting Shorter , 1994 .

[3]  Robert Kirschbaum,et al.  Open Innovation In Practice , 2005 .

[4]  Jean Hartley,et al.  Case study research , 2004 .

[5]  J. West,et al.  Open innovation : researching a new paradigm , 2008 .

[6]  R. Yin.  Case Study Research: Design and Methods , 1984 .

[7]  Donald C. Hambrick,et al.  Strategic awareness within top management teams , 1981 .

[8]  Dirk Voelkel,et al.  Managing Open Innovation in Biotechnology , 2006 .

[9]  H. Chesbrough,et al.  Beyond High Tech: Early Adopters of Open Innovation in Other Industries , 2006 .

[10]  Jorge Niosi.  Fourth-Generation R&D: From Linear Models to Flexible Innovation , 1999 .

[11]  V. Chiesa,et al.  La bioindustria - strategie competitive e organizzazione industriale nel settore delle biotecnologie farmaceutiche , 2003 .

[12]  Oliver Gassmann,et al.  Organizing Pharmaceutical Innovation: From Science‐based Knowledge Creators to Drug‐oriented Knowledge Brokers , 2005 .

[13]  Eckhard Lichtenthaler,et al.  Organising the external technology exploitation process: current practices and future challenges , 2004, Int. J. Technol. Manag..

[14]  Henry Chesbrough,et al.  Open Innovation: The New Imperative for Creating and Profiting from Technology , 2003 .

[15]  Markku V. J. Maula,et al.  Open innovation in systemic innovation contexts , 2006 .

[16]  Roland Ortt,et al.  Innovation management: different approaches to cope with the same trends , 2006, Int. J. Technol. Manag..

[17]  W. Vanhaverbeke,et al.  Choosing Governance Modes for External Technology Sourcing , 2006 .

[18]  David L. Deeds,et al.  The impact of stocks and flows of organizational knowledge on firm performance: an empirical investigation of the biotechnology industry , 1999 .

[19]  Hildy Teegen,et al.  Factors affecting foreign R&D location decisions: management and host policy implications , 2003, Int. J. Technol. Manag..

[20]  Ulrich Lichtenthaler,et al.  Developing reputation to overcome the imperfections in the markets for knowledge , 2007 .

[21]  P. Duin,et al.  The evolution of innovation management towards contextual innovation , 2008 .

[22]  Henry Chesbrough,et al.  The Logic of Open Innovation: Managing Intellectual Property , 2003 .

[23]  David Wilemon,et al.  Changing patterns in industrial R&D management , 1996 .

[24]  M. Dodgson,et al.  The Role of Technology in the Shift Towards Open Innovation: The Case of Procter & Gamble , 2006 .

[25]  T. Kuhn,et al.  The Structure of Scientific Revolutions. , 1964 .

[26]  Janette Moody,et al.  Toward a Better Understanding of Information Technology Organization: A Comparative Case Study , 1992, MIS Q..

[27]  Giuseppe Giardina,et al.  INNOVAZIONI NEI PROCESSI DI RICERCA IN CAMPO FARMACEUTICO , 2003 .

[28]  E. Roberts.  Benchmarking Global Strategic Management of Technology , 2001 .

[29]  Georges Haour,et al.  Resolving the Innovation Paradox: Enhancing Growth in Technology Companies , 2003 .

[30]  Walter W. Powell,et al.  A Comparison of U.S. and European University-Industry Relations in the Life Sciences , 2001 .

[31]  Sladjana Nørskov,et al.  On-Line Innovation: The Case of Open Source Software Development , 2008 .

[32]  N. Sakkab,et al.  Connect and Develop : Inside Procter & Gamble's New Model for Innovation , 2006 .

[33]  Anoop Madhok,et al.  The International Biotechnology Industry: A Dynamic Capabilities Perspective , 2000 .

[34]  Vittorio Chiesa,et al.  How to sell technology services to innovators:evidence from nanotech Italian companies , 2007 .

[35]  J. West,et al.  Challenges of Open Innovation: The Paradox of Firm Investment in Open-Source Software , 2006 .

[36]  M. Perkmann,et al.  University Industry Relationships and Open Innovation: Towards a Research Agenda , 2007 .

[37]  Jens Frøslev Christensen,et al.  The industrial dynamics of Open Innovation—Evidence from the transformation of consumer electronics , 2005 .

[38]  Davide Chiaroni,et al.  The knowledge-bridging role of Technical and Scientific Services in knowledge-intensive industries , 2008, Int. J. Technol. Manag..

[39]  Deb Chatterji,et al.  Accessing External Sources of Technology , 1996 .

[40]  Oliver Gassmann,et al.  Opening Up the Innovation Process: Towards an Agenda , 2006 .

[41]  Stefanie Bröring,et al.  Organising new business development: open innovation at Degussa , 2008 .

[42]  Kenneth W. Koput,et al.  The Spatial Clustering of Science and Capital: Accounting for Biotech Firm-Venture Capital Relationships , 2002 .

[43]  Henry Chesbrough,et al.  Open Innovation: A research agenda , 2006 .

[44]  Davide Chiaroni,et al.  Industrial Clusters In Biotechnology: Driving Forces, Development Processes And Management Practices , 2004 .

[45]  H. Chesbrough.  Managing Open Innovation , 2004 .