Large Size Cells in the Visceral Adipose Depot Predict Insulin Resistance in the Canine Model

[1]  Samuel W. Cushman,et al.  Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis , 2010, Diabetes.

[2]  P. Schauer,et al.  Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis* , 2009, The Journal of Biological Chemistry.

[3]  E. Ravussin,et al.  Differential Effect of Weight Loss on Adipocyte Size Subfractions in Patients With Type 2 Diabetes , 2009, Obesity.

[4]  Taro Matsumoto,et al.  Differences in Adipocytokines and Fatty Acid Composition between Two Adipocyte Fractions of Small and Large Cells in High-Fat Diet-Induced Obese Mice , 2009, Annals of Nutrition and Metabolism.

[5]  R. Bergman,et al.  Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs. , 2009, American journal of physiology. Endocrinology and metabolism.

[6]  R. Bergman,et al.  Greater Omentectomy Improves Insulin Sensitivity in Nonobese Dogs , 2009, Obesity.

[7]  G. Bray,et al.  Lower Total Adipocyte Number but No Evidence for Small Adipocyte Depletion in Patients With Type 2 Diabetes , 2009, Diabetes Care.

[8]  E. Schoenle,et al.  Basal lipolysis, not the degree of insulin resistance, differentiates large from small isolated adipocytes in high-fat fed mice , 2009, Diabetologia.

[9]  U. Pagotto,et al.  Cannabinoid Type 1 Receptor: Another Arrow in the Adipocytes’ Bow , 2008, Journal of neuroendocrinology.

[10]  Lisa M Sullivan,et al.  New Scanning Electron Microscopic Method for Determination of Adipocyte Size in Humans and Mice , 2007, Obesity.

[11]  A. Sherman,et al.  Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis , 2007, Diabetologia.

[12]  R. Bergman,et al.  Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia. , 2007, American journal of physiology. Endocrinology and metabolism.

[13]  C. Herder,et al.  Relationship between adipocyte size and adipokine expression and secretion. , 2007, The Journal of clinical endocrinology and metabolism.

[14]  F. Renström,et al.  Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’ , 2007, Diabetologia.

[15]  B. Scatton,et al.  The Canadian Consortium for the Investigation of Cannabinoids in Human Therapeutics , 2022 .

[16]  Richard N Bergman,et al.  Why Visceral Fat is Bad: Mechanisms of the Metabolic Syndrome , 2006, Obesity.

[17]  J. Després,et al.  Is visceral obesity the cause of the metabolic syndrome? , 2006, Annals of medicine.

[18]  R. Bergman,et al.  Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. , 2005, American journal of physiology. Endocrinology and metabolism.

[19]  H. Tilg,et al.  Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. , 2004, Biochemical and biophysical research communications.

[20]  R. Bergman,et al.  Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog. , 2003, Diabetes.

[21]  C. Flachskamm,et al.  The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. , 2003, The Journal of clinical investigation.

[22]  F. Lönnqvist,et al.  A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding , 2002, International Journal of Obesity.

[23]  N. Barzilai,et al.  Surgical removal of visceral fat reverses hepatic insulin resistance. , 1999, Diabetes.

[24]  F. Lönnqvist,et al.  Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men. , 1997, Journal of lipid research.

[25]  J. Olefsky,et al.  Decreased Activation Rate of Insulin-Stimulated Glucose Transport in Adipocytes From Obese Subjects , 1989, Diabetes.

[26]  P. Arner,et al.  Lipolysis in human adipocytes, effects of cell size, age and of regional differences. , 1988, Hormone and metabolic research. Supplement series.

[27]  R N Bergman,et al.  Estimation of Endogenous Glucose Production During Hyperinsulinemic-Euglycemic Glucose Clamps: Comparison of Unlabeled and Labeled Exogenous Glucose Infusates , 1987, Diabetes.

[28]  P. Julien,et al.  Regional variation in HDL metabolism in human fat cells: effect of cell size. , 1987, The American journal of physiology.

[29]  R G Hoffmann,et al.  Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women. , 1984, Metabolism: clinical and experimental.

[30]  L. Sjöström,et al.  Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. , 1983, The Journal of clinical investigation.

[31]  A. Kissebah,et al.  Relation of body fat distribution to metabolic complications of obesity. , 1982, The Journal of clinical endocrinology and metabolism.

[32]  S. Cushman,et al.  Studies of human adipose tissue. Adipose cell size and number in nonobese and obese patients. , 1973, The Journal of clinical investigation.

[33]  J. Hirsch,et al.  Adipose-cell size and immunoreactive insulin levels in obese and normal-weight adults. , 1972, Lancet.

[34]  M. Rodbell.  METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. , 1964, The Journal of biological chemistry.

[35]  V. Dole,et al.  Microdetermination of long-chain fatty acids in plasma and tissues. , 1960, The Journal of biological chemistry.