Regulation of adrenergic receptor function by phosphorylation.

[1]  M. Caron,et al.  Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit. , 1986, The Journal of biological chemistry.

[2]  M. Caron,et al.  Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[3]  D. Sibley,et al.  A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase. , 1986, Biochemistry.

[4]  M. Caron,et al.  Purification and characterization of the human platelet alpha 2-adrenergic receptor. , 1986, The Journal of biological chemistry.

[5]  David R. Sibley,et al.  Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model , 1985, Nature.

[6]  M. Caron,et al.  Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[7]  M. Caron,et al.  Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. , 1985, The Journal of biological chemistry.

[8]  R. Snyderman,et al.  Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. , 1985, The Journal of biological chemistry.

[9]  D. Sibley,et al.  Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. , 1985, The Journal of biological chemistry.

[10]  J. Williamson,et al.  Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes. , 1985, The Journal of biological chemistry.

[11]  M. Ui,et al.  Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system. , 1985, The Journal of biological chemistry.

[12]  C. Lynch,et al.  Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate. , 1985, The Journal of biological chemistry.

[13]  D. Sibley,et al.  Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor. , 1985, The Journal of biological chemistry.

[14]  Michael J. Berridge,et al.  Inositol trisphosphate, a novel second messenger in cellular signal transduction , 1984, Nature.

[15]  C. W. Scott,et al.  Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase. , 1984, Biochemistry.

[16]  M. Caron,et al.  The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. , 1984, Biochemistry.

[17]  M. Caron,et al.  The mammalian beta 2-adrenergic receptor: purification and characterization. , 1984, Biochemistry.

[18]  D. Sibley,et al.  Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. , 1984, The Journal of biological chemistry.

[19]  B. Strulovici,et al.  Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system. , 1984, Science.

[20]  D. Sibley,et al.  Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity. , 1984, The Journal of biological chemistry.

[21]  J. Pessin,et al.  Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[22]  D. Sibley,et al.  Phorbol diesters promote beta-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes. , 1984, Biochemical and biophysical research communications.

[23]  M. Caron,et al.  Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine. , 1984, The Journal of biological chemistry.

[24]  M. Berridge.  Inositol trisphosphate and diacylglycerol as second messengers. , 1984, The Biochemical journal.

[25]  Y. Nishizuka.  The role of protein kinase C in cell surface signal transduction and tumour promotion , 1984, Nature.

[26]  D. Sibley,et al.  Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors. , 1984, Journal of Biological Chemistry.

[27]  S. Corvera,et al.  Phorbol esters inhibit alpha 1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes. , 1984, Biochemical and biophysical research communications.

[28]  A. Gilman.  G proteins and dual control of adenylate cyclase , 1984, Cell.

[29]  P. Molinoff,et al.  Agonist-induced changes in the properties of beta-adrenergic receptors on intact S49 lymphoma cells. Time-dependent changes in the affinity of the receptor for agonists. , 1984, Molecular pharmacology.

[30]  B. Strulovici,et al.  Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase , 1983, Nature.

[31]  L. Mahan,et al.  Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization. , 1983, The Journal of biological chemistry.

[32]  R. Iyengar,et al.  Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines. , 1983, Archives of biochemistry and biophysics.

[33]  M. Caron,et al.  Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[34]  B. Strulovici,et al.  Functional integrity of desensitized beta-adrenergic receptors. , 1983, The Journal of biological chemistry.

[35]  T. K. Harden,et al.  Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase. , 1983, Pharmacological reviews.

[36]  S. Kassis,et al.  Different mechanisms of desensitization of adenylate cyclase by isoproterenol and prostaglandin E1 in human fibroblasts. Role of regulatory components in desensitization. , 1982, The Journal of biological chemistry.

[37]  R. Clark,et al.  Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells. , 1981, The Journal of biological chemistry.

[38]  T. K. Harden,et al.  Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process. , 1980, The Journal of biological chemistry.

[39]  P. Coffino,et al.  Kinase-negative mutants of S49 mouse lymphoma cells carry a trans-dominant mutation affecting expression of cAMP-dependent protein kinase , 1978, Cell.

[40]  H. Wotiz,et al.  Estrogen-binding protein in mouse and rat adrenal glands. , 1978, The Journal of biological chemistry.

[41]  M. Caron,et al.  Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. , 1983, Annual review of biochemistry.

[42]  J. Niedel,et al.  Phorbol diester receptor copurifies with protein kinase C. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[43]  E. Pugh,et al.  Chapter 9 Control of Rod Disk Membrane Phosphodiesterase and a Model for Visual Transduction , 1981 .

[44]  M. Caron,et al.  Regulation of adenylate cyclase coupled beta-adrenergic receptors. , 1976, Recent progress in hormone research.