Temporal dynamics in fMRI resting-state activity

In a significant new study, Mitra et al. (1) demonstrate the existence of reproducible temporal patterns of spontaneous activity from human functional magnetic resonance imaging (fMRI) recordings. This finding and the novel methods used to demonstrate it bring the question of the role of temporally patterned activity into the domain of human cognition.

[1]  R. Yuste,et al.  Visual stimuli recruit intrinsically generated cortical ensembles , 2014, Proceedings of the National Academy of Sciences.

[2]  Ohad Ben-Shahar,et al.  Stochastic Emergence of Repeating Cortical Motifs in Spontaneous Membrane Potential Fluctuations In Vivo , 2007, Neuron.

[3]  Dean V Buonomano,et al.  Timing of neural responses in cortical organotypic slices , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[4]  G. Buzsáki,et al.  Sequential structure of neocortical spontaneous activity in vivo , 2007, Proceedings of the National Academy of Sciences.

[5]  Justin L. Vincent,et al.  Intrinsic Fluctuations within Cortical Systems Account for Intertrial Variability in Human Behavior , 2007, Neuron.

[6]  S. Hecht,et al.  ENERGY, QUANTA, AND VISION , 1942, The Journal of general physiology.

[7]  Brendon O. Watson,et al.  Internal Dynamics Determine the Cortical Response to Thalamic Stimulation , 2005, Neuron.

[8]  Marcus E Raichle,et al.  A Paradigm Shift in Functional Brain Imaging , 2009, The Journal of Neuroscience.

[9]  M. Raichle,et al.  Lag threads organize the brain’s intrinsic activity , 2015, Proceedings of the National Academy of Sciences.

[10]  E. Vaadia,et al.  Spatiotemporal firing patterns in the frontal cortex of behaving monkeys. , 1993, Journal of neurophysiology.

[11]  Yuji Ikegaya,et al.  Synfire Chains and Cortical Songs: Temporal Modules of Cortical Activity , 2004, Science.

[12]  Yuji Ikegaya,et al.  Statistical Significance of Precisely Repeated Intracellular Synaptic Patterns , 2008, PloS one.

[13]  Christopher D. Harvey,et al.  Choice-specific sequences in parietal cortex during a virtual-navigation decision task , 2012, Nature.

[14]  Adrienne L. Fairhall,et al.  Intrinsic Neuronal Properties Switch the Mode of Information Transmission in Networks , 2014, PLoS Comput. Biol..

[15]  Kevin L. Briggman,et al.  Optical Imaging of Neuronal Populations During Decision-Making , 2005, Science.

[16]  Charles J. Wilson,et al.  Spontaneous firing patterns of identified spiny neurons in the rat neostriatum , 1981, Brain Research.

[17]  A. Grinvald,et al.  Spontaneously emerging cortical representations of visual attributes , 2003, Nature.

[18]  William Bialek,et al.  Spikes: Exploring the Neural Code , 1996 .

[19]  R. Llinás.  I of the Vortex: From Neurons to Self , 2000 .