Self-Activated Electrical Stimulation for Effective Hair Regeneration via a Wearable Omnidirectional Pulse Generator.

Hair loss, a common and distressing symptom, has been plaguing humans. Various pharmacological and nonpharmacological treatments have been widely studied to achieve the desired effect for hair regeneration. As a nonpharmacological physical approach, physiologically appropriate alternating electric field plays a key role in the field of regenerative tissue engineering. Here, a universal motion-activated and wearable electric stimulation device that can effectively promote hair regeneration via random body motions was designed. Significantly facilitated hair regeneration results were obtained from Sprague-Dawley rats and nude mice. Higher hair follicle density and longer hair shaft length were observed on Sprague-Dawley rats when the device was employed compared to conventional pharmacological treatments. The device can also improve the secretion of vascular endothelial growth factor and keratinocyte growth factor and thereby alleviate hair keratin disorder, increase the number of hair follicles, and promote hair regeneration on genetically defective nude mice. This work provides an effective hair regeneration strategy in the context of a nonpharmacological self-powered wearable electronic device.

[1]  Irene Georgakoudi,et al.  Skin Rejuvenation with Non-Invasive Pulsed Electric Fields , 2015, Scientific Reports.

[2]  Mi-Ra Lee,et al.  In vivo hair growth-stimulating effect of medicinal plant extract on BALB/c nude mice , 2015, Pharmaceutical biology.

[3]  J. Helms,et al.  Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth. , 2016, The Journal of investigative dermatology.

[4]  Jung Ho Shin,et al.  Trichogenic Photostimulation Using Monolithic Flexible Vertical AlGaInP Light-Emitting Diodes. , 2018, ACS nano.

[5]  Elaine Fuchs,et al.  Scratching the surface of skin development , 2007, Nature.

[6]  Daniel M. Vogt,et al.  Embedded 3D Printing of Strain Sensors within Highly Stretchable Elastomers , 2014, Advanced materials.

[7]  S. Tiwari,et al.  Human Mesenchymal Stem Cell-Derived Conditioned Media for Hair Regeneration Applications. , 2016, Journal of stem cells.

[8]  Yonggang Huang,et al.  Compliant and stretchable thermoelectric coils for energy harvesting in miniature flexible devices , 2018, Science Advances.

[9]  S. Kanji,et al.  Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration , 2017, Mediators of inflammation.

[10]  Martin L Yarmush,et al.  Non-thermal, pulsed electric field cell ablation: A novel tool for regenerative medicine and scarless skin regeneration. , 2013, Technology.

[11]  J. E. Kim,et al.  Hair growth‐promotion effects of different alternating current parameter settings are mediated by the activation of Wnt/β‐catenin and MAPK pathway , 2015, Experimental dermatology.

[12]  T. Dąbrowski Hair loss as a consequence of cancer chemotherapy – physical methods of prevention. A review of the literature , 2011 .

[13]  WuXunwei,et al.  Full-Thickness Skin with Mature Hair Follicles Generated from Tissue Culture Expanded Human Cells , 2014 .

[14]  E. Fuchs,et al.  The hair cycle , 2006, Journal of Cell Science.

[15]  Zhong Lin Wang,et al.  Eye motion triggered self-powered mechnosensational communication system using triboelectric nanogenerator , 2017, Science Advances.

[16]  J. Harman,et al.  Pulsed electrostatic fields (ETG) to reduce hair loss in women undergoing chemotherapy for breast carcinoma: A pilot study , 2002, Psycho-oncology.

[17]  S. Ledbetter,et al.  Secretion of stromelysin by cultured dermal papilla cells: Differential regulation by growth factors and functional role in mitogen‐induced cell proliferation , 1992, Journal of cellular physiology.

[18]  R. Paus,et al.  Learning from nudity: lessons from the nude phenotype , 2005, Experimental dermatology.

[19]  R Paus,et al.  A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. , 2001, The Journal of investigative dermatology.

[20]  W. Sollecito,et al.  ELECTROTRICHOGENESIS: FURTHER EVIDENCE OF EFFICACY AND SAFETY ON EXTENDED USE , 1992, International journal of dermatology.

[21]  Jonathan A. Fan,et al.  Stretchable batteries with self-similar serpentine interconnects and integrated wireless recharging systems , 2013, Nature Communications.

[22]  Xunwei Wu,et al.  Human Reconstructed Skin in a Mouse Model. , 2019, Methods in molecular biology.

[23]  Ruth E. Baker,et al.  Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration , 2008, Nature.

[24]  T. Lotti,et al.  Clinical evaluation of a novel fractional radiofrequency device for hair growth: Fractional radiofrequency for hair growth stimulation , 2018, Dermatologic therapy.

[25]  Zhong Lin Wang,et al.  Triboelectric microplasma powered by mechanical stimuli , 2018, Nature Communications.

[26]  Jun Li,et al.  Effective weight control via an implanted self-powered vagus nerve stimulation device , 2018, Nature Communications.

[27]  Caofeng Pan,et al.  Triboelectric-generator-driven pulse electrodeposition for micropatterning. , 2012, Nano letters.

[28]  Long Lin,et al.  Grating‐Structured Freestanding Triboelectric‐Layer Nanogenerator for Harvesting Mechanical Energy at 85% Total Conversion Efficiency , 2014, Advanced materials.

[29]  S. Wasielewski,et al.  [Treatment for hair loss]. , 2000, Medizinische Monatsschrift fur Pharmazeuten.

[30]  Yang Zou,et al.  Biodegradable triboelectric nanogenerator as a life-time designed implantable power source , 2016, Science Advances.

[31]  Minoru Suzuki,et al.  Association of a mutation in TRPV3 with defective hair growth in rodents. , 2006, The Journal of investigative dermatology.

[32]  John P McQuilling,et al.  Application of low-frequency alternating current electric fields via interdigitated electrodes: effects on cellular viability, cytoplasmic calcium, and osteogenic differentiation of human adipose-derived stem cells. , 2010, Tissue engineering. Part C, Methods.

[33]  O. Kwon,et al.  The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors. , 2017, Current stem cell research & therapy.

[34]  H. Wolff [Hair loss in women]. , 2010, MMW Fortschritte der Medizin.

[35]  Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis , 2016, Science.

[36]  Yunlong Zi,et al.  Triboelectric nanogenerators for sensitive nano-coulomb molecular mass spectrometry. , 2017, Nature nanotechnology.

[37]  M. Detmar,et al.  Control of hair growth and follicle size by VEGF-mediated angiogenesis. , 2001, The Journal of clinical investigation.

[38]  A. Christiano,et al.  Pharmacologic inhibition of JAK-STAT signaling promotes hair growth , 2015, Science Advances.

[39]  J. James,et al.  The Biological Effects of a Pulsed Electrostatic Field with Specific Reference to Hair Electrotrichogenesis , 1990, International journal of dermatology.

[40]  Zhong Lin Wang,et al.  A Sliding-Mode Triboelectric Nanogenerator with Chemical Group Grated Structure by Shadow Mask Reactive Ion Etching. , 2017, ACS nano.

[41]  J. Guilbaud,et al.  Essential oils and low-intensity electromagnetic pulses in the treatment of androgen-dependent alopecia , 2003, Advances in therapy.

[42]  Jerry Shapiro,et al.  Pattern hair loss in men: diagnosis and medical treatment. , 2013, Dermatologic clinics.

[43]  A. Tosti,et al.  EVIDENCE BASED ( S 3 ) GUIDELINES FOR THE TREATMENT OF ANDROGENETIC ALOPECIA IN WOMEN AND IN MEN , 2011 .

[44]  C. Chuong,et al.  Aging, alopecia, and stem cells , 2016, Science.

[45]  V. Botchkarev,et al.  Molecular control of epithelial-mesenchymal interactions during hair follicle cycling. , 2003, The journal of investigative dermatology. Symposium proceedings.

[46]  Nicole E Rogers,et al.  Medical treatments for male and female pattern hair loss. , 2008, Journal of the American Academy of Dermatology.

[47]  D. Danilenko,et al.  Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. , 1995, The American journal of pathology.

[48]  M. Senna,et al.  The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern , 2018, American Journal of Clinical Dermatology.

[49]  P. Strauss,et al.  Changes in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatment. , 1999, Journal of the American Academy of Dermatology.

[50]  M. Stiller,et al.  STATUS OF MEDICAL TREATMENT FOR ANDROGENETIC ALOPECIA , 1993, International journal of dermatology.

[51]  A. Tosti,et al.  Evidence‐based (S3) guideline for the treatment of androgenetic alopecia in women and in men , 2011, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[52]  T. Someya,et al.  Self-powered ultra-flexible electronics via nano-grating-patterned organic photovoltaics , 2018, Nature.

[53]  Hyung-Min Chung,et al.  Potential application of adipose-derived stem cells and their secretory factors to skin: discussion from both clinical and industrial viewpoints , 2010, Expert opinion on biological therapy.