Combining antiepileptic drugs—Rational polytherapy?

[1]  P. Kwan,et al.  Drug-resistant epilepsy. , 2011, The New England journal of medicine.

[2]  M. Brodie,et al.  Pharmacotherapy of Epilepsy , 2011, CNS drugs.

[3]  M. Backer,et al.  A Pooled Analysis of Lacosamide Clinical Trial Data Grouped by Mechanism of Action of Concomitant Antiepileptic Drugs , 2010, CNS drugs.

[4]  Gary W. Mathern,et al.  Erratum: Definition of drug resistant epilepsy. Consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies (Epilepsia (2010) 51 (1069-77)) , 2010 .

[5]  C. V. van Donselaar,et al.  Course and outcome of childhood epilepsy: A 15‐year follow‐up of the Dutch Study of Epilepsy in Childhood , 2010, Epilepsia.

[6]  C. Stafstrom.  Mechanisms of action of antiepileptic drugs: the search for synergy , 2010, Current opinion in neurology.

[7]  Patrick Kwan,et al.  Definition of refractory epilepsy: defining the indefinable? , 2010, The Lancet Neurology.

[8]  C. Supuran,et al.  The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors. , 2010, Journal of medicinal chemistry.

[9]  K. Stavem,et al.  Placebo‐corrected efficacy of modern antiepileptic drugs for refractory epilepsy: Systematic review and meta‐analysis , 2010, Epilepsia.

[10]  G. Mathern,et al.  Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies , 2009, Epilepsia.

[11]  M. Brodie,et al.  Selection of antiepileptic drugs in adults. , 2009, Neurologic clinics.

[12]  J. French,et al.  Rational polytherapy , 2009, Epilepsia.

[13]  M. Brodie,et al.  Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: A randomized placebo‐controlled trial , 2009, Epilepsia.

[14]  E. S. St. Louis.  Truly “Rational” Polytherapy: Maximizing Efficacy and Minimizing Drug Interactions, Drug Load, and Adverse Effects , 2009, Current neuropharmacology.

[15]  E. S. Louis.  Truly "rational" polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects. , 2009 .

[16]  A. Berg,et al.  Remission of epilepsy after two drug failures in children: A prospective study , 2009, Annals of neurology.

[17]  J. Fisher.  The anti-convulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator , 2009, Neuropharmacology.

[18]  G. Krauss,et al.  Rufinamide for generalized seizures associated with Lennox–Gastaut syndrome , 2008, Neurology.

[19]  Y. Schiller,et al.  Quantifying the response to antiepileptic drugs , 2008, Neurology.

[20]  G. Lees,et al.  The Investigational Anticonvulsant Lacosamide Selectively Enhances Slow Inactivation of Voltage-Gated Sodium Channels , 2008, Molecular Pharmacology.

[21]  H. Klitgaard,et al.  Levetiracetam: the first SV2A ligand for the treatment of epilepsy , 2007, Expert opinion on drug discovery.

[22]  S. Shorvon,et al.  Results of treatment changes in patients with apparently drug‐resistant chronic epilepsy , 2007, Annals of neurology.

[23]  W. Hauser,et al.  Likelihood of seizure remission in an adult population with refractory epilepsy , 2007, Annals of neurology.

[24]  P. Kwan,et al.  Emerging drugs for epilepsy , 2007, Expert opinion on emerging drugs.

[25]  J. French,et al.  Seizure‐Free Outcome in Randomized Add‐on Trials of the New Antiepileptic Drugs , 2007, Epilepsia.

[26]  John Norrie,et al.  Mortality in epilepsy , 2007, Epilepsy & Behavior.

[27]  Peter Burkart,et al.  Pharmacology, Efficacy, and Tolerability of Potassium Bromide in Childhood Epilepsy , 2007, Journal of child neurology.

[28]  M. Danhof,et al.  Synergistic Combinations of Anticonvulsant Agents: What Is the Evidence from Animal Experiments? , 2007, Epilepsia.

[29]  S. Donevan,et al.  Ca2+ channel α2δ ligands: novel modulators of neurotransmission , 2007 .

[30]  R. Tallarida,et al.  An Overview of Drug Combination Analysis with Isobolograms , 2006, Journal of Pharmacology and Experimental Therapeutics.

[31]  G. Johnston.  GABA(A) receptor channel pharmacology. , 2005, Current pharmaceutical design.

[32]  M. Brodie.  Medical therapy of epilepsy: When to initiate treatment and when to combine? , 2005, Journal of Neurology.

[33]  J. Luszczki,et al.  Preclinical Profile of Combinations of Some Second‐generation Antiepileptic Drugs: An Isobolographic Analysis , 2004, Epilepsia.

[34]  Wolfgang Löscher,et al.  The neurobiology of antiepileptic drugs , 2004, Nature Reviews Neuroscience.

[35]  K. Nocka,et al.  The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[36]  G. Battaglia,et al.  The genesis of epileptogenic cerebral heterotopia: clues from experimental models. , 2003, Epileptic disorders : international epilepsy journal with videotape.

[37]  M. Rogawski,et al.  Selective Antagonism of GluR5 Kainate-Receptor-Mediated Synaptic Currents by Topiramate in Rat Basolateral Amygdala Neurons , 2003, The Journal of Neuroscience.

[38]  J. Kiś,et al.  Interactions of Lamotrigine with Topiramate and First‐generation Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis , 2003, Epilepsia.

[39]  G. Sills.  Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine. , 2003, Epileptic disorders : international epilepsy journal with videotape.

[40]  K. Borowicz,et al.  Polytherapy in epilepsy: the experimental evidence , 2002, Epilepsy Research.

[41]  J. Armijo,et al.  Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. , 2002, European journal of pharmacology.

[42]  K. Borowicz,et al.  Effect of Gabapentin on the Anticonvulsant Activity of Antiepileptic Drugs against Electroconvulsions in Mice: An Isobolographic Analysis , 2002, Epilepsia.

[43]  M. Brodie,et al.  Seizure freedom with more than one antiepileptic drug , 2002, Seizure.

[44]  B Malgrange,et al.  The anti‐epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA‐ and glycine‐gated currents , 2002, British journal of pharmacology.

[45]  Patrick Kwan,et al.  Staged approach to epilepsy management , 2002, Neurology.

[46]  V. Shkryl,et al.  Selective Blockade of N‐Type Calcium Channels by Levetiracetam , 2002, Epilepsia.

[47]  Josemir W Sander,et al.  A Pharmacoepidemiologic Study of Factors Influencing the Outcome of Treatment with Lamotrigine in Chronic Epilepsy , 2001, Epilepsia.

[48]  P. Kwan,et al.  The mechanisms of action of commonly used antiepileptic drugs. , 2001, Pharmacology & therapeutics.

[49]  C. Elger,et al.  Oxcarbazepine Placebo‐Controlled, Dose‐Ranging Trial in Refractory Partial Epilepsy , 2000, Epilepsia.

[50]  P. Patsalos,et al.  Selection of Antiepileptic Drug Polytherapy Based on Mechanisms of Action: The Evidence Reviewed , 2000, Epilepsia.

[51]  Patrick Kwan,et al.  Epilepsy after the first drug fails: substitution or add-on? , 2000, Seizure.

[52]  P. Kwan,et al.  Early identification of refractory epilepsy. , 2000, The New England journal of medicine.

[53]  R. Shank,et al.  Topiramate as an Inhibitor of Carbonic Anhydrase Isoenzymes , 2000, Epilepsia.

[54]  Markus Missler,et al.  SV2A and SV2B Function as Redundant Ca2+ Regulators in Neurotransmitter Release , 1999, Neuron.

[55]  E. Perucca,et al.  The Efficacy of Valproate‐Lamotrigine Comedication in Refractory Complex Partial Seizures: Evidence for a Pharmacodynamic Interaction , 1999, Epilepsia.

[56]  R. Stern,et al.  Lamotrigine‐Associated Rash: Risk/Benefit Considerations in Adults and Children , 1999, Epilepsia.

[57]  Wolfgang Löscher,et al.  Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action , 1999, Progress in Neurobiology.

[58]  M. Brodie,et al.  Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy , 1999, Epilepsy Research.

[59]  R. Mattson,et al.  Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy , 1999, Neurology.

[60]  M. Okada,et al.  Interaction between Ca2+, K+, carbamazepine and zonisamide on hippocampal extracellular glutamate monitored with a microdialysis electrode , 1998, British journal of pharmacology.

[61]  G. De Sarro,et al.  Gabapentin potentiates the antiseizure activity of certain anticonvulsants in DBA/2 mice. , 1998, European journal of pharmacology.

[62]  M. Brodie,et al.  Lamotrigine and topiramate may be a useful combination , 1998, The Lancet.

[63]  M. Avoli,et al.  Sodium channels as molecular targets for antiepileptic drugs , 1998, Brain Research Reviews.

[64]  D. Berry,et al.  Carbamazepine Toxicity with Lamotrigine: Pharmacokinetic or Pharmacodynamic Interaction? , 1998, Epilepsia.

[65]  G. Bernardi,et al.  Voltage‐Activated Calcium Channels: Targets of Antiepileptic Drug Therapy? , 1997, Epilepsia.

[66]  H. Meinardi,et al.  Reappraisal of Polytherapy in Epilepsy: A Critical Review of Drug Load and Adverse Effects , 1997, Epilepsia.

[67]  J. Rho,et al.  Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. , 1997, The Journal of pharmacology and experimental therapeutics.

[68]  M. Brodie,et al.  Lamotrigine substitution study: evidence for synergism with sodium valproate? , 1997, Epilepsy Research.

[69]  S. Donevan,et al.  Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons. , 1996, The Journal of physiology.

[70]  K. Hsu,et al.  Inhibition of N‐type calcium currents by lamotrigine in rat amygdalar neurones , 1996, Neuroreport.

[71]  W. Reiss,et al.  Acetazolamide in the Treatment of Seizures , 1996, The Annals of pharmacotherapy.

[72]  C. Ribak,et al.  GABA plasma membrane transporters, GAT‐1 and GAT‐3, display different distributions in the rat hippocampus , 1996 .

[73]  U. Aguglia,et al.  Lamotrigine potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice , 1996, Neuropharmacology.

[74]  R. Mattson,et al.  The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy , 1996, Annals of neurology.

[75]  R. Mcquade,et al.  Felbamate, a novel antiepileptic drug, reverses N-methyl-D-aspartate/glycine-stimulated increases in intracellular Ca2+ concentration. , 1995, European journal of pharmacology.

[76]  M. Brodie,et al.  Synergism with GABAergic drugs in refractory epilepsy , 1994, The Lancet.

[77]  M. McLean,et al.  Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture , 1994, Epilepsy Research.

[78]  W. Catterall,et al.  Cellular and molecular biology of voltage-gated sodium channels. , 1992, Physiological reviews.

[79]  K. Yagi,et al.  Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex , 1992, Epilepsy Research.

[80]  W. Catterall,et al.  Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs. , 1991, Molecular pharmacology.

[81]  P. Suzdak,et al.  Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. , 1991, European journal of pharmacology.

[82]  R. Gross,et al.  Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons , 1990, Neuroscience Letters.

[83]  H. Mclennan,et al.  Electrophysiological properties of rat CA1 pyramidal neurones in vitro modified by changes in extracellular bicarbonate. , 1989, The Journal of physiology.

[84]  D. Prince,et al.  Characterization of ethosuximide reduction of low‐threshold calcium current in thalamic neurons , 1989, Annals of neurology.

[85]  W. Löscher,et al.  Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations , 1988, Epilepsy Research.

[86]  J. Morris,et al.  Phenytoin and carbamazepine, alone and in combination , 1987, Neurology.

[87]  B. Bourgeois.  Antiepileptic drug combinations and experimental background: The case of phenobarbital and phenytoin , 1986, Naunyn-Schmiedeberg's Archives of Pharmacology.

[88]  R. Macdonald,et al.  Multiple actions of phenytoin on mouse spinal cord neurons in cell culture. , 1983, The Journal of pharmacology and experimental therapeutics.

[89]  A. Rowan,et al.  Valproate-ethosuximide combination therapy for refractory absence seizures. , 1983, Archives of neurology.

[90]  K. Courtney,et al.  Modulated anticonvulsant block of sodium channels in nerve and muscle. , 1983, European journal of pharmacology.

[91]  P. Schechter,et al.  γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE 1 , 1977, Journal of neurochemistry.

[92]  B. G. White,et al.  The efficacy of carbamazepine combinations in epilepsy , 1975, Clinical pharmacology and therapeutics.

[93]  J. Millichap,et al.  Mechanism of the anticonvulsant action of acetazoleamide, a carbonic anhydrase inhibitor. , 1955, The Journal of pharmacology and experimental therapeutics.

[94]  L. Goodman,et al.  Studies on anticonvulsant drug combinations: phenobarbital and diphenylhydantoin. , 1955, The Journal of pharmacology and experimental therapeutics.

[95]  M. Bialer,et al.  Key factors in the discovery and development of new antiepileptic drugs , 2010, Nature Reviews Drug Discovery.

[96]  P. Kwan,et al.  IMPROVED OUTCOMES IN NEWLY DIAGNOSED EPILEPSY , 2009 .

[97]  M. Brodie,et al.  ANTIEPILEPTIC DRUGS | Preclinical Drug Development in Epilepsy , 2009 .

[98]  Patrick Kwan,et al.  Combination therapy in epilepsy: when and what to use. , 2006, Drugs.

[99]  M. Avoli,et al.  Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture , 2004, Experimental Brain Research.

[100]  E. Valdizán,et al.  Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. , 2002, European journal of pharmacology.

[101]  P. Patsalos,et al.  The New Generation of GABA Enhancers , 2001, CNS drugs.

[102]  R. Macdonald,et al.  Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital. , 1989, Annals of neurology.