CD147 augmented monocarboxylate transporter-1/4 expression through modulation of the Akt-FoxO3-NF-κB pathway promotes cholangiocarcinoma migration and invasion

[1]  A. Engelbrecht,et al.  Role of PKM2 in directing the metabolic fate of glucose in cancer: a potential therapeutic target , 2018, Cellular Oncology.

[2]  M. Schwab,et al.  Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy , 2018, Clinical and translational science.

[3]  Jing Wang,et al.  Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1 , 2017, Oncogene.

[4]  Paweena Dana,et al.  Upregulation of CD147 Promotes Metastasis of Cholangiocarcinoma by Modulating the Epithelial-to-Mesenchymal Transitional Process , 2017, Oncology research.

[5]  C. Jeffery,et al.  Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression , 2017, Scientific Reports.

[6]  K. Sawanyawisuth,et al.  Overexpression of lactate dehydrogenase A in cholangiocarcinoma is correlated with poor prognosis. , 2017, Histology and histopathology.

[7]  S. Wongkham,et al.  Targeting hexokinase II as a possible therapy for cholangiocarcinoma. , 2017, Biochemical and biophysical research communications.

[8]  M. Tang,et al.  Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway , 2017, Journal of Cancer Research and Clinical Oncology.

[9]  Ziyao Wang,et al.  Post-translational modifications of FOXO family proteins (Review). , 2016, Molecular medicine reports.

[10]  I. Novak,et al.  Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells , 2016, Pancreas.

[11]  C. Denlinger,et al.  Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma , 2016, Cancer.

[12]  E. Lam,et al.  STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment , 2016, Tumor Biology.

[13]  L. Hellman,et al.  FOXO3–NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function , 2015, The Journal of Immunology.

[14]  Hidemasa Bono,et al.  CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites , 2014, Bioinform..

[15]  Shi Chang,et al.  RNA interference targeting CD147 inhibits the proliferation, invasiveness, and metastatic activity of thyroid carcinoma cells by down-regulating glycolysis. , 2015, International journal of clinical and experimental pathology.

[16]  Gang Liu,et al.  The Monocarboxylate Transporter 4 Is Required for Glycolytic Reprogramming and Inflammatory Response in Macrophages* , 2014, The Journal of Biological Chemistry.

[17]  S. Okada,et al.  Aberrant Expression of NF-κB in Liver Fluke Associated Cholangiocarcinoma: Implications for Targeted Therapy , 2014, PloS one.

[18]  Hushan Yang,et al.  CD147-CD98hc Complex Contributes to Poor Prognosis of Non-Small Cell Lung Cancer Patients Through Promoting Cell Proliferation Via the PI3K/Akt Signaling Pathway , 2014, Annals of Surgical Oncology.

[19]  Hong-zhao Li,et al.  Downregulation of FOXO3a Promotes Tumor Metastasis and Is Associated with Metastasis-Free Survival of Patients with Clear Cell Renal Cell Carcinoma , 2014, Clinical Cancer Research.

[20]  G. Riggins,et al.  Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy , 2013, Tumor Biology.

[21]  L. Yao,et al.  EMMPRIN/CD147 expression is associated with disease-free survival of patients with colorectal cancer , 2013, Medical Oncology.

[22]  M. Honavar,et al.  Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. , 2013, Neuro-oncology.

[23]  Jan Koster,et al.  FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma. , 2013, Cancer research.

[24]  H. Thomas,et al.  Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update , 2012, Gut.

[25]  E. Nagata,et al.  Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death , 2012, Proceedings of the National Academy of Sciences.

[26]  I. Udalova,et al.  FOXO3 as a new IKK‐ε‐controlled check‐point of regulation of IFN‐β expression , 2012, European journal of immunology.

[27]  M. Casal,et al.  Role of monocarboxylate transporters in human cancers: state of the art , 2012, Journal of Bioenergetics and Biomembranes.

[28]  A. Halestrap,et al.  The monocarboxylate transporter family—Role and regulation , 2012, IUBMB life.

[29]  J. Tavernier,et al.  HAb18G/CD147 promotes cell motility by regulating annexin II‐activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells , 2011, Hepatology.

[30]  G. Tzivion,et al.  FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. , 2011, Biochimica et biophysica acta.

[31]  S. Obchoei,et al.  Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma , 2011, Molecular Cancer.

[32]  J. Paik,et al.  FoxO family members in cancer , 2011, Cancer biology & therapy.

[33]  Y. Sasaguri,et al.  Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells , 2011, Cancer science.

[34]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[35]  Yong Li,et al.  Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression , 2010, British Journal of Cancer.

[36]  F. Oswald,et al.  CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models , 2009, Gut.

[37]  J. Zou,et al.  CD147 Expression Indicates Unfavourable Prognosis in Prostate Cancer , 2009, Pathology & Oncology Research.

[38]  C. Pairojkul,et al.  Cholangiocarcinoma: lessons from Thailand , 2008, Current opinion in gastroenterology.

[39]  A. Borthakur,et al.  Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: Involvement of NF‐κB pathway , 2008 .

[40]  A. Brunet,et al.  FOXO transcription factors , 2007, Current Biology.

[41]  E. Greer,et al.  FOXO transcription factors at the interface between longevity and tumor suppression , 2005, Oncogene.

[42]  D. Longo,et al.  Phosphorylation of RelA/p65 on Serine 536 Defines an IκBα-independent NF-κB Pathway* , 2005, Journal of Biological Chemistry.

[43]  M. Hemler,et al.  Metabolic Activation-related CD147-CD98 Complex*S , 2005, Molecular & Cellular Proteomics.

[44]  R. Wyman,et al.  Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture , 2005, Journal of Cell Science.

[45]  M. Miwa,et al.  Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100). , 2005, World journal of gastroenterology.

[46]  K. Umezawa,et al.  Targeting of nuclear factor kappaB Pathways by dehydroxymethylepoxyquinomicin, a novel inhibitor of breast carcinomas: antitumor and antiangiogenic potential in vivo. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[47]  D. Longo,et al.  Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway. , 2005, The Journal of biological chemistry.

[48]  A. Barclay,et al.  CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression , 2000, The EMBO journal.

[49]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[50]  H. Guo,et al.  The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. , 1995, Cancer research.

[51]  C. Biswas Tumor cell stimulation of collagenase production by fibroblasts. , 1982, Biochemical and biophysical research communications.

[52]  O. Warburg,et al.  IRON, THE OXYGEN-CARRIER OF RESPIRATION-FERMENT. , 1925, Science.