Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors.
暂无分享,去创建一个
[1] B. Cochran,et al. Inducible binding of a factor to the c-fos regulatory region. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[2] J E Darnell,et al. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. , 1988, Genes & development.
[3] Peter Angel,et al. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1 , 1988, Cell.
[4] J. Darnell,et al. Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. , 1989, Genes & development.
[5] G. Stark,et al. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway , 1989, Molecular and cellular biology.
[6] M. Montminy,et al. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 , 1989, Cell.
[7] J. Darnell,et al. ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[8] D. Levy,et al. Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. , 1990, Genes & development.
[9] B. Kemp,et al. Protein kinase recognition sequence motifs. , 1990, Trends in biochemical sciences.
[10] M. Karin,et al. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73 , 1991, Nature.
[11] J. Manak,et al. Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II , 1991, Molecular and cellular biology.
[12] M. Karin,et al. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. , 1991, Biochimica et biophysica acta.
[13] R. Pearse,et al. Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[14] James R. Woodgett,et al. Phosphorylation of c-jun mediated by MAP kinases , 1991, Nature.
[15] T. Curran,et al. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. , 1991, The Journal of biological chemistry.
[16] V. N. Roa,et al. Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF , 1991, Nature.
[17] J. Darnell,et al. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons , 1991, Molecular and cellular biology.
[18] Tony Hunter,et al. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity , 1991, Cell.
[19] T. Decker,et al. Cytoplasmic activation of GAF, an IFN‐gamma‐regulated DNA‐binding factor. , 1991, The EMBO journal.
[20] J. Ferrell,et al. Inhibition of c-Jun DNA binding by mitogen-activated protein kinase. , 1992, Molecular biology of the cell.
[21] M. Hagiwara,et al. Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB , 1992, Cell.
[22] M. Fellous,et al. A protein tyrosine kinase in the interferon α β signaling pathway , 1992, Cell.
[23] R. Aebersold,et al. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins , 1992, Molecular and cellular biology.
[24] M. Karin,et al. Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73 , 1992, Molecular and cellular biology.
[25] H. Stunnenberg,et al. Identification of multiple SRF N‐terminal phosphorylation sites affecting DNA binding properties. , 1992, The EMBO journal.
[26] R. Aebersold,et al. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[27] M. Karin,et al. Control of transcription factors by signal transduction pathways: the beginning of the end. , 1992, Trends in biochemical sciences.
[28] J. Darnell,et al. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. , 1992, Science.
[29] E. Krebs,et al. The mitogen-activated protein kinase activator. , 1992, Current opinion in cell biology.
[30] C. Crews,et al. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. , 1992, Science.
[31] Sheila M. Thomas,et al. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases , 1992, Cell.
[32] R. Treisman. The serum response element. , 1992, Trends in biochemical sciences.
[33] T. Haystead,et al. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. , 1992, Science.
[34] J. Kurjan. Pheromone response in yeast. , 1992, Annual review of biochemistry.
[35] David L. Brautigan,et al. Raf-1 activates MAP kinase-kinase , 1992, Nature.
[36] Xin-Yuan Fu. A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s) , 1992, Cell.
[37] Rao Vn,et al. elk-1 domains responsible for autonomous DNA binding, SRE:SRF interaction and negative regulation of DNA binding. , 1992 .
[38] A. Sharrocks,et al. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter , 1992, Nature.
[39] J. Darnell,et al. Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. , 1992, Science.
[40] T. Pawson,et al. SH2 and SH3 domains: From structure to function , 1992, Cell.
[41] D. Brenner,et al. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity , 1992, Cell.
[42] R. Treisman,et al. Casein kinase II phosphorylation increases the rate of serum response factor‐binding site exchange. , 1992, The EMBO journal.
[43] Tony Hunter,et al. The regulation of transcription by phosphorylation , 1992, Cell.
[44] M. Karin,et al. The mammalian ultraviolet response is triggered by activation of src tyrosine kinases , 1992, Cell.
[45] Alfred Nordheim,et al. Elk-1 protein domains required for direct and SRF-assisted DNA-binding , 1992, Nucleic Acids Res..
[46] S. Jackson,et al. Regulating transcription factor activity by phosphorylation. , 1992, Trends in cell biology.
[47] R. Aebersold,et al. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[48] Hong Sun,et al. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo , 1993, Cell.
[49] M. Karin,et al. A novel cis element mediating ligand-independent activation by c-ErbA: Implications for hormonal regulation , 1993, Cell.
[50] S. Cohen,et al. Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. , 1993, Science.
[51] G L Johnson,et al. Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation , 1993, Molecular and cellular biology.
[52] Andrew Ziemiecki,et al. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins , 1993, Nature.
[53] R. Davis,et al. Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus , 1993, The Journal of cell biology.
[54] O. Silvennoinen,et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin , 1993, Cell.
[55] D. S. Webb,et al. Tyrosine phosphorylation of DNA binding proteins by multiple cytokines. , 1993, Science.
[56] D. Levy,et al. Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity , 1993, Molecular and cellular biology.
[57] R. Hipskind,et al. c‐fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF. , 1993, The EMBO journal.
[58] H. Sadowski,et al. Cell-free activation of a DNA-binding protein by epidermal growth factor , 1993, Nature.
[59] G. Stark,et al. Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway , 1993, Nature.
[60] O. Silvennoinen,et al. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase , 1993, Cell.
[61] E. Elion,et al. FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1. , 1993, Molecular biology of the cell.
[62] D. Levy,et al. Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. , 1993, Science.
[63] J. Darnell,et al. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. , 1993, Science.
[64] G. Stark,et al. The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction , 1993, Nature.
[65] T. Hunter. Cytokine connections , 1993, Nature.
[66] Masatoshi Hagiwara,et al. Phosphorylated CREB binds specifically to the nuclear protein CBP , 1993, Nature.
[67] M. Karin,et al. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. , 1993, Genes & development.
[68] Richard Treisman,et al. Functional analysis of a growth factor-responsive transcription factor complex , 1993, Cell.
[69] Xin-Yuan Fu,et al. Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter , 1993, Cell.
[70] Walter Kolch,et al. Protein kinase Cα activates RAF-1 by direct phosphorylation , 1993, Nature.
[71] R. Treisman,et al. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain , 1993, Cell.
[72] R. Davis,et al. The mitogen-activated protein kinase signal transduction pathway. , 1993, The Journal of biological chemistry.
[73] Jonathan A. Cooper,et al. Mammalian Ras interacts directly with the serine/threonine kinase raf , 1993, Cell.
[74] D. Brenner,et al. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[75] M. Karin,et al. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain , 1994, Cell.