Tracing the action of IL‐2 in tolerance to islet‐specific antigen

[1]  J. Rogers,et al.  Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity , 2007, Nature Genetics.

[2]  A. Rudensky,et al.  An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires , 2006, Nature Immunology.

[3]  L. Klein,et al.  Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling , 2005, Nature Immunology.

[4]  A. Rudensky,et al.  A function for interleukin 2 in Foxp3-expressing regulatory T cells , 2005, Nature Immunology.

[5]  N. Sarvetnick,et al.  CD8+ T Cell Tolerance in Nonobese Diabetic Mice Is Restored by Insulin-Dependent Diabetes Resistance Alleles1 , 2005, The Journal of Immunology.

[6]  G. Eisenbarth,et al.  Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice , 2005, Nature.

[7]  Adrian Vella,et al.  Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. , 2005, American journal of human genetics.

[8]  D. Gray,et al.  Genetic lesions in T‐cell tolerance and thresholds for autoimmunity , 2005, Immunological reviews.

[9]  T. Malek,et al.  Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period , 2005, The Journal of experimental medicine.

[10]  Shimon Sakaguchi,et al.  Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization , 2005, The Journal of experimental medicine.

[11]  L. Peltonen,et al.  Gene Dosage–limiting Role of Aire in Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity , 2004, The Journal of experimental medicine.

[12]  N. Sarvetnick,et al.  Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity , 2004, Cell.

[13]  F. Ramsdell,et al.  An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.

[14]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[15]  T. Nomura,et al.  Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .

[16]  C. Goodnow,et al.  Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes , 2002, The Journal of experimental medicine.

[17]  T. Malek,et al.  CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. , 2002, Immunity.

[18]  T. Hünig,et al.  IL-2 and autoimmune disease. , 2002, Cytokine & growth factor reviews.

[19]  S. Carding,et al.  A Requirement for IL-2/IL-2 Receptor Signaling in Intrathymic Negative Selection1 , 2001, The Journal of Immunology.

[20]  J. Todd,et al.  Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene? , 2000, Cytokine.

[21]  Yan Zhou,et al.  Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo. , 1999 .

[22]  D. Peterson,et al.  The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. , 1998, Immunity.

[23]  M. Davis,et al.  A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. , 1997, Immunity.

[24]  H. Dadi,et al.  Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor , 1997 .

[25]  B. Ludviksson,et al.  Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes. , 1997, Journal of immunology.

[26]  T. Hünig,et al.  Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene , 1995, The Journal of experimental medicine.

[27]  F. Alt,et al.  Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. , 1995, Immunity.

[28]  H. Griesser,et al.  Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. , 1995, Science.

[29]  D. Kioussis,et al.  Thymic selection and peptide‐induced activation of T cell receptor‐transgenic CD8 T cells in interleukin‐2‐deficient mice , 1994, European journal of immunology.

[30]  M P Cooke,et al.  Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells , 1994, The Journal of experimental medicine.

[31]  A. Feller,et al.  Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene , 1993, Cell.

[32]  I. Horak,et al.  Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting , 1991, Nature.

[33]  A. Rudensky,et al.  Foxp 3 programs the development and function of CD 4 + CD 25 + regulatory T cells , 2003 .

[34]  H. Dadi,et al.  Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. , 1997, Proceedings of the National Academy of Sciences of the United States of America.