Blocking CCN2 Reduces Established Bone Loss Induced by Prolonged Intense Loading by Increasing Osteoblast Activity in Rats

[1]  Shan-Chi Liu,et al.  CCN2 Facilitates IL‐17 Production and Osteoclastogenesis in Human Osteoarthritis Synovial Fibroblasts by Inhibiting miR‐655 Expression , 2022, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  M. Barbe,et al.  Manual Therapy Facilitates Homeostatic Adaptation to Bone Microstructural Declines Induced by a Rat Model of Repetitive Forceful Task , 2022, International journal of molecular sciences.

[3]  Alex G. Lambi,et al.  Blocking CCN2 preferentially inhibits osteoclastogenesis induced by repetitive high force bone loading , 2020, Connective tissue research.

[4]  L. Richeldi,et al.  Pamrevlumab for the treatment of idiopathic pulmonary fibrosis , 2020, Expert opinion on investigational drugs.

[5]  M. Barbe,et al.  Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse‐induced median mononeuropathy , 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[6]  F. Beuschlein,et al.  The Effect of Biochemical Remission on Bone Metabolism in Cushing's Syndrome: A 2‐Year Follow‐Up Study , 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  Jae-Hyung Lee,et al.  Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis , 2020, International journal of medical sciences.

[8]  A. Leask.  Breathe, breathe in the air: the anti-CCN2 antibody pamrevlumab (FG-3019) completes a successful phase II clinical trial for idiopathic pulmonary fibrosis , 2019, Journal of cell communication and signaling.

[9]  M. Barbe,et al.  Blocking CCN2 Reduces Progression of Sensorimotor Declines and Fibrosis in a Rat Model of Chronic Repetitive Overuse , 2019, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[10]  B. V. D. van der Eerden,et al.  Osteocalcin—A Versatile Bone-Derived Hormone , 2019, Front. Endocrinol..

[11]  M. Karsdal,et al.  Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort , 2018, bioRxiv.

[12]  M. Barbe,et al.  Manual therapy prevents onset of nociceptor activity, sensorimotor dysfunction, and neural fibrosis induced by a volitional repetitive task , 2018, Pain.

[13]  R. Goldschmeding,et al.  Connective tissue growth factor (CTGF) from basics to clinics. , 2018, Matrix biology : journal of the International Society for Matrix Biology.

[14]  M. Barbe,et al.  Prolonged high force high repetition pulling induces osteocyte apoptosis and trabecular bone loss in distal radius, while low force high repetition pulling induces bone anabolism. , 2018, Bone.

[15]  Ju Wang,et al.  Synergistic effects of fibroblast growth factor-2 and bone morphogenetic protein-2 on bone induction , 2017, Molecular medicine reports.

[16]  H. Bimonte-Nelson,et al.  Modeling menopause: The utility of rodents in translational behavioral endocrinology research. , 2016, Maturitas.

[17]  M. Sternlicht,et al.  FG-3019, a Human Monoclonal Antibody Recognizing Connective Tissue Growth Factor, is Subject to Target-Mediated Drug Disposition , 2016, Pharmaceutical Research.

[18]  M. Barbe,et al.  Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury , 2016, Journal of the Neurological Sciences.

[19]  C. Wade,et al.  Prolonged performance of a high repetition low force task induces bone adaptation in young adult rats, but loss in mature rats , 2015, Experimental Gerontology.

[20]  L. Bonewald,et al.  Bone and muscle: Interactions beyond mechanical. , 2015, Bone.

[21]  M. Takigawa,et al.  CCN2 enhances RANKL-induced osteoclast differentiation via direct binding to RANK and OPG. , 2015, Bone.

[22]  K. Avin,et al.  Bone is Not Alone: the Effects of Skeletal Muscle Dysfunction in Chronic Kidney Disease , 2015, Current Osteoporosis Reports.

[23]  M. Barbe,et al.  Ergonomic task reduction prevents bone osteopenia in a rat model of upper extremity overuse , 2015, Industrial health.

[24]  K. Avin,et al.  Biomechanical Aspects of the Muscle-Bone Interaction , 2015, Current Osteoporosis Reports.

[25]  C. Wade,et al.  Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury , 2015, Journal of Cell Communication and Signaling.

[26]  Ganesh Thiagarajan,et al.  Experimental and finite element analysis of dynamic loading of the mouse forearm , 2014, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[27]  S. Popoff,et al.  Connective Tissue Growth Factor (CTGF/CCN2) Negatively Regulates BMP‐2 Induced Osteoblast Differentiation and Signaling , 2014, Journal of cellular physiology.

[28]  C. Wade,et al.  Bone loss from high repetitive high force loading is prevented by ibuprofen treatment. , 2014, Journal of musculoskeletal & neuronal interactions.

[29]  S. Gallagher,et al.  The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders , 2013, BMC Musculoskeletal Disorders.

[30]  Satoshi Kubota,et al.  The CCN family acting throughout the body: recent research developments , 2013, Biomolecular concepts.

[31]  Sean Gallagher,et al.  Examining the Interaction of Force and Repetition on Musculoskeletal Disorder Risk , 2013, Hum. Factors.

[32]  J. Kanis,et al.  Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[33]  Alex G. Lambi,et al.  The Skeletal site‐specific role of connective tissue growth factor in prenatal osteogenesis , 2012, Developmental dynamics : an official publication of the American Association of Anatomists.

[34]  W. Hauswirth,et al.  CCN2/CTGF regulates neovessel formation via targeting structurally conserved cystine knot motifs in multiple angiogenic regulators , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[35]  Lester F. Lau,et al.  Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets , 2011, Nature Reviews Drug Discovery.

[36]  K. Lyons,et al.  CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell–specific transmembrane protein (DC‐STAMP) , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[37]  Qingjian Wang,et al.  Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease , 2011, Fibrogenesis & tissue repair.

[38]  Ralph Müller,et al.  Guidelines for assessment of bone microstructure in rodents using micro–computed tomography , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[39]  A. Barr,et al.  Induction of Periostin-like Factor and Periostin in Forearm Muscle, Tendon, and Nerve in an Animal Model of Work-related Musculoskeletal Disorder , 2009, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[40]  M. Goppelt‐Struebe,et al.  Connective tissue growth factor: Context‐dependent functions and mechanisms of regulation , 2009, BioFactors.

[41]  D. Durant,et al.  Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. , 2008, Endocrinology.

[42]  Y. Yoshihama,et al.  Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma. , 2008, Anticancer research.

[43]  Monique H. W. Frings-Dresen,et al.  Quality of life and illness perception in working and sick-listed chronic RSI patients , 2007, International archives of occupational and environmental health.

[44]  A. Barr,et al.  Repetitive, Negligible Force Reaching in Rats Induces Pathological Overloading of Upper Extremity Bones , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[45]  Jie Xu,et al.  Expression of connective tissue growth factor in bone: Its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo , 2003, Journal of cellular physiology.

[46]  B. Yoon,et al.  Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development , 2003, Development.

[47]  H. Inoue,et al.  Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing. , 2002, Bone.

[48]  Ulf Lundberg,et al.  Psychophysiology of work: stress, gender, endocrine response, and work-related upper extremity disorders. , 2002, American journal of industrial medicine.

[49]  D. Kleinbaum,et al.  A prospective study of computer users: I. Study design and incidence of musculoskeletal symptoms and disorders. , 2002, American journal of industrial medicine.

[50]  T. Sugimoto,et al.  Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. , 2001, Biochemical and biophysical research communications.

[51]  G. Raghu,et al.  Pamrevlumab, an anti-connective tissue growth factor therapy, for idiopathic pulmonary fibrosis (PRAISE): a phase 2, randomised, double-blind, placebo-controlled trial. , 2019, The Lancet. Respiratory medicine.

[52]  Matthew R Allen,et al.  Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. , 2012, Bone.

[53]  Alex G. Lambi,et al.  The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis. , 2011, Critical reviews in eukaryotic gene expression.

[54]  P. Delmas,et al.  Bone markers. , 1997, Bailliere's clinical rheumatology.