What do dendrites and their synapses tell the neuron?

This essay looks at the historical significance of four APS classic papers that are freely available online: Rall W. Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. J Neurophysiol 30: 1138-1168, 1967 (http://jn.physiology.org/cgi/reprint/30/5/1138). Rall W, Burke RE, Smith TG, Nelson PG, and Frank K. Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons. J Neurophysiol 30: 1169-1193, 1967 (http://jn.physiology.org/cgi/reprint/30/5/1169). Rall W and Shepherd GM. Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. J Neurophysiol 31: 884-915, 1968 (http://jn.physiology.org/cgi/reprint/31/6/884). Segev I and Rall W. Computational study of an excitable dendritic spine. J Neurophysiol 60: 499-523, 1988 (http://jn.physiology.org/cgi/reprint/60/2/499).

[1]  Bartlett W. Mel,et al.  Pyramidal Neuron as Two-Layer Neural Network , 2003, Neuron.

[2]  G M Shepherd,et al.  Dendrodendritic synaptic pathway for inhibition in the olfactory bulb. , 1966, Experimental neurology.

[3]  C. Nicholson.  Electric current flow in excitable cells J. J. B. Jack, D. Noble &R. W. Tsien Clarendon Press, Oxford (1975). 502 pp., £18.00 , 1976, Neuroscience.

[4]  W. Rall.  Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. , 1967, Journal of neurophysiology.

[5]  W. Rall.  Time constants and electrotonic length of membrane cylinders and neurons. , 1969, Biophysical journal.

[6]  Eric R. Kandel,et al.  Cellular biology of neurons , 1977 .

[7]  J Rinzel,et al.  Propagation of dendritic spikes mediated by excitable spines: a continuum theory. , 1991, Journal of neurophysiology.

[8]  M. London,et al.  Dendritic computation. , 2005, Annual review of neuroscience.

[9]  Mitchell Glickstein,et al.  Foundations of the neuron doctrine , 1993, Medical History.

[10]  J Rinzel,et al.  Transient response in a dendritic neuron model for current injected at one branch. , 1974, Biophysical journal.

[11]  Idan Segev,et al.  The theoretical foundation of dendritic function: Selected papers of Wilfrid Rall with commentaries , 1994 .

[12]  Bartlett W. Mel,et al.  Computational subunits in thin dendrites of pyramidal cells , 2004, Nature Neuroscience.

[13]  A. Borst.  The theoretical foundation of dendritic function edited by I. Segev, J. Rinzel and G.M. Shepherd, The MIT Press, 1995. $55.00 (vii + 465 pages) ISBN 0 262 19356 6 , 1995, Trends in Neurosciences.

[14]  Christof Koch,et al.  The role of single neurons in information processing , 2000, Nature Neuroscience.

[15]  T. Poggio,et al.  Retinal ganglion cells: a functional interpretation of dendritic morphology. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[16]  M. Taussig.  The Nervous System , 1991 .

[17]  G. Shepherd,et al.  Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. , 1968, Journal of neurophysiology.

[18]  R. Burke,et al.  Electrotonic characteristics of alpha motoneurones of varying size , 1971, The Journal of physiology.

[19]  W Rall,et al.  Computational study of an excitable dendritic spine. , 1988, Journal of neurophysiology.

[20]  G. Shepherd,et al.  Logic operations are properties of computer-simulated interactions between excitable dendritic spines , 1987, Neuroscience.

[21]  W Rall,et al.  Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons. , 1967, Journal of neurophysiology.

[22]  W. Rall.  Branching dendritic trees and motoneuron membrane resistivity. , 1959, Experimental neurology.

[23]  J Rinzel,et al.  Branch input resistance and steady attenuation for input to one branch of a dendritic neuron model. , 1973, Biophysical journal.