Scanned carbon-ion beam therapy throughput over the first 7 years at National Institute of Radiological Sciences.

INTRODUCTION In the 7 years since our facility opened, we have treated >2000 patients with pencil-beam scanned carbon-ion beam therapy. METHODS To summarize treatment workflow, we evaluated the following five metrics: i) total number of treated patients; ii) treatment planning time, not including contouring procedure; iii) quality assurance (QA) time (daily and patient-specific); iv) treatment room occupancy time, including patient setup, preparation time, and beam irradiation time; and v) daily treatment hours. These were derived from the oncology information system and patient handling system log files. RESULTS The annual number of treated patients reached 594, 7 years from the facility startup, using two treatment rooms. Mean treatment planning time was 6.0 h (minimum: 3.4 h for prostate, maximum: 9.3 h for esophagus). Mean time devoted to daily QA and patient-specific QA were 22 min and 13.5 min per port, respectively, for the irradiation beam system. Room occupancy time was 14.5 min without gating for the first year, improving to 9.2 min (8.2 min without gating and 12.8 min with gating) in the second. At full capacity, the system ran for 7.5 h per day. CONCLUSIONS We are now capable of treating approximately 600 patients per year in two treatment rooms. Accounting for the staff working time, this performance appears reasonable compared to the other facilities.

[1]  Takuji Furukawa,et al.  Patient-specific QA and delivery verification of scanned ion beam at NIRS-HIMAC. , 2013, Medical physics.

[2]  Katsuyuki Tanimoto,et al.  Carbon-Ion Pencil Beam Scanning Treatment With Gated Markerless Tumor Tracking: An Analysis of Positional Accuracy. , 2016, International journal of radiation oncology, biology, physics.

[3]  Tohru Okada,et al.  Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS). , 2010, Journal of radiation research.

[4]  K. Herfarth,et al.  Acute Toxicity and Quality of Life in Patients With Prostate Cancer Treated With Protons or Carbon Ions in a Prospective Randomized Phase II Study--The IPI Trial. , 2016, International journal of radiation oncology, biology, physics.

[5]  Suresh Senan,et al.  Stereotactic radiotherapy for peripheral lung tumors: a comparison of volumetric modulated arc therapy with 3 other delivery techniques. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[6]  S. Mori,et al.  Systematic evaluation of four-dimensional hybrid depth scanning for carbon-ion lung therapy. , 2013, Medical physics.

[7]  N. Matsufuji,et al.  Monte Carlo study of out-of-field exposure in carbon-ion radiotherapy with a passive beam: Organ doses in prostate cancer treatment. , 2018, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[8]  S. Mori,et al.  Effect of patient positioning on carbon-ion therapy planned dose distribution to pancreatic tumors and organs at risk. , 2017, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[9]  Y. Shioyama,et al.  A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas. , 2018, Anticancer research.

[10]  Yoshiyuki Iwata,et al.  Performance of the NIRS fast scanning system for heavy-ion radiotherapy. , 2010, Medical physics.

[11]  S. Mori,et al.  Respiration-gated fast-rescanning carbon-ion radiotherapy , 2017, Japanese journal of clinical oncology.

[12]  H. Tsujii,et al.  Carbon ion radiotherapy for sacral chordoma. , 2011, The British journal of radiology.

[13]  Y. Shioyama,et al.  Carbon-ion radiotherapy for patients with advanced stage non–small-cell lung cancer at multicenters , 2017, Journal of radiation research.

[14]  Martha M Matuszak,et al.  Volumetric modulated arc therapy for delivery of hypofractionated stereotactic lung radiotherapy: A dosimetric and treatment efficiency analysis. , 2010, Radiotherapy and Oncology.

[15]  Takuji Furukawa,et al.  Patient handling system for carbon ion beam scanning therapy , 2012, Journal of applied clinical medical physics.

[16]  T. Nakano,et al.  Carbon-ion radiotherapy for inoperable endometrial carcinoma , 2018, Journal of radiation research.

[17]  J. Fowler,et al.  Late outcomes following hypofractionated conformal radiotherapy vs. standard fractionation for localized prostate cancer: a nonrandomized contemporary comparison. , 2009, International journal of radiation oncology, biology, physics.

[18]  S. Mori,et al.  Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four-dimensional computed tomography. , 2017, The British journal of radiology.

[19]  Anton Mans,et al.  Volumetric-modulated arc therapy for stereotactic body radiotherapy of lung tumors: a comparison with intensity-modulated radiotherapy techniques. , 2011, International journal of radiation oncology, biology, physics.

[20]  R. Orecchia,et al.  Risk of carotid blowout after reirradiation with particle therapy , 2017, Advances in radiation oncology.

[21]  A. Lomax,et al.  Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: the potential effects of calculational uncertainties , 2008, Physics in medicine and biology.

[22]  W. De Neve,et al.  In search of the economic sustainability of Hadron therapy: the real cost of setting up and operating a Hadron facility. , 2014, International journal of radiation oncology, biology, physics.

[23]  T. Inaniwa,et al.  Influence of nuclear interactions in body tissues on tumor dose in carbon-ion radiotherapy. , 2015, Medical physics.

[24]  Hiroshi Honda,et al.  Carbon Ion Radiation Therapy With Concurrent Gemcitabine for Patients With Locally Advanced Pancreatic Cancer. , 2016, International journal of radiation oncology, biology, physics.

[25]  Shinji Sato,et al.  Moving target irradiation with fast rescanning and gating in particle therapy. , 2010, Medical physics.

[26]  Shinichiro Mori,et al.  Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer. , 2016, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[27]  Julia Bauer,et al.  Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma – feasibility and clinical response , 2013, Radiation Oncology.

[28]  E. Pedroni,et al.  The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization. , 1995, Medical physics.

[29]  S. Mori,et al.  Impact of treatment planning with deformable image registration on dose distribution for carbon-ion beam lung treatment using a fixed irradiation port and rotating couch. , 2015, The British journal of radiology.

[30]  Hideaki Haneishi,et al.  Development of fast patient position verification software using 2D-3D image registration and its clinical experience , 2015, Journal of radiation research.

[31]  K. Herfarth,et al.  Carbon ion beam treatment in patients with primary and recurrent sacrococcygeal chordoma , 2015, Strahlentherapie und Onkologie.

[32]  F. Valvo,et al.  Surgical spacer placement prior carbon ion radiotherapy (CIRT): an effective feasible strategy to improve the treatment for sacral chordoma , 2016, World Journal of Surgical Oncology.

[33]  Katsuyuki Tanimoto,et al.  First clinical experience in carbon ion scanning beam therapy: retrospective analysis of patient positional accuracy , 2012, Journal of radiation research.

[34]  S. Mori,et al.  Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation , 2016, Journal of radiation research.

[35]  Shinichiro Mori,et al.  Gated carbon-ion scanning treatment for pancreatic tumour with field specific target volume and organs at risk. , 2016, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[36]  Philippe Lambin,et al.  How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[37]  Susumu Kandatsu,et al.  Carbon Ion Radiotherapy for Stage I Non-small Cell Lung Cancer Using a Regimen of Four Fractions during 1 Week , 2007, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[38]  S. Endo,et al.  Postoperative recurrence of rectal cancer , 2014 .

[39]  H. Tsujii,et al.  Outcomes of visual acuity in carbon ion radiotherapy: analysis of dose-volume histograms and prognostic factors. , 2006, International journal of radiation oncology, biology, physics.

[40]  S. Sato,et al.  Development of beam current control system in RF-knockout slow extraction , 2011 .

[41]  T Inaniwa,et al.  Implementation of a target volume design function for intrafractional range variation in a particle beam treatment planning system. , 2014, The British journal of radiology.

[42]  T. Shirai,et al.  Reformulation of a clinical-dose system for carbon-ion radiotherapy treatment planning at the National Institute of Radiological Sciences, Japan , 2015, Physics in medicine and biology.

[43]  J. M. Schippers,et al.  The use of protons in cancer therapy at PSI and related instrumentation , 2006 .

[44]  H. Tsujii,et al.  Phase I/II trial of definitive carbon ion radiotherapy for prostate cancer: evaluation of shortening of treatment period to 3 weeks , 2014, British Journal of Cancer.