Functional Mapping of the Human Brain

A review of current and potential imaging techniques that can be used to map human brain activity is presented. The most advanced method, i.e. positron emission tomography (PET) and repeated cerebral blood flow (CBF) imaging with oxygen-15 labelled water is then further detailed, including recent advances and current unsolved questions in the acquisition and analysis of such data. The major results obtained using this technique in adults in the field of speech and face processing are then discussed. Finally, the feasibility of applying some of these imaging techniques to the study of cognitive functions in infancy is discussed.

[1]  S. Petersen,et al.  Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli. , 1990, Science.

[2]  Alan C. Evans,et al.  Anatomical-Functional Correlation Using an Adjustable MRI-Based Region of Interest Atlas with Positron Emission Tomography , 1988, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  M Corbetta,et al.  Attentional modulation of neural processing of shape, color, and velocity in humans. , 1990, Science.

[4]  R Kikinis,et al.  MR Imaging of Brain Maturation in Normal and Developmentally Handicapped Children , 1990, Journal of computer assisted tomography.

[5]  Karl J. Friston,et al.  The colour centre in the cerebral cortex of man , 1989, Nature.

[6]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[7]  M. Raichle,et al.  A Stereotactic Method of Anatomical Localization for Positron Emission Tomography , 1985, Journal of computer assisted tomography.

[8]  M. Mintun,et al.  Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation. , 1983, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  B.M. Mazoyer,et al.  3-D segmentation, interpolation and delineation of cortical gyri on MRI data , 1991, Conference Record of the 1991 IEEE Nuclear Science Symposium and Medical Imaging Conference.

[10]  Leslie G. Ungerleider,et al.  Dissociation of object and spatial visual processing pathways in human extrastriate cortex. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[11]  J. Sergent,et al.  Functional neuroanatomy of face and object processing. A positron emission tomography study. , 1992, Brain : a journal of neurology.

[12]  R. Hari,et al.  Recording and interpretation of cerebral magnetic fields. , 1989, Science.

[13]  M. Phelps,et al.  Maturational changes in cerebral function in infants determined by 18FDG positron emission tomography. , 1986, Science.

[14]  R. Turner,et al.  Echo-planar imaging: magnetic resonance imaging in a fraction of a second. , 1991, Science.

[15]  F M Miezin,et al.  Activation of the hippocampus in normal humans: a functional anatomical study of memory. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Lutz Jäncke,et al.  Anatomical left‐right asymmetry of language‐related temporal cortex is different in left‐ and right‐handers , 1991, Annals of neurology.

[17]  Karl J. Friston,et al.  A PET study of word finding , 1991, Neuropsychologia.

[18]  R P Crease.  Images of conflict: MEG vs. EEG. , 1991, Science.

[19]  R. Turner,et al.  Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[20]  M. Raichle,et al.  Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis. , 1983, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[21]  A. Galaburda,et al.  Individual variability in cortical organization: Its relationship to brain laterality and implications to function , 1990, Neuropsychologia.

[22]  Karl J. Friston,et al.  Distribution of cortical neural networks involved in word comprehension and word retrieval. , 1991, Brain : a journal of neurology.

[23]  C. Pelizzari,et al.  Accurate Three‐Dimensional Registration of CT, PET, and/or MR Images of the Brain , 1989, Journal of computer assisted tomography.

[24]  H. Chugani,et al.  Functional brain imaging in pediatrics. , 1992, Pediatric clinics of North America.

[25]  George J. Carman,et al.  In vivo functional localization of the human visual cortex using positron emission tomography and magnetic resonance imaging , 1989, Trends in Neurosciences.

[26]  N. Tzourio,et al.  Different mental imagery abilities result in different regional cerebral blood flow activation patterns during cognitive tasks , 1992, Neuropsychologia.

[27]  Alan C. Evans,et al.  Anatomical mapping of functional activation in stereotactic coordinate space , 1992, NeuroImage.

[28]  B. Rosen,et al.  Functional mapping of the human visual cortex by magnetic resonance imaging. , 1991, Science.

[29]  P. Lauterbur,et al.  Image Formation by Induced Local Interactions: Examples Employing Nuclear Magnetic Resonance , 1973, Nature.

[30]  G. Hounsfield.  Computerized transverse axial scanning (tomography): Part I. Description of system. 1973. , 1973, The British journal of radiology.

[31]  P. T. Fox,et al.  Positron emission tomographic studies of the cortical anatomy of single-word processing , 1988, Nature.

[32]  M. Corbetta,et al.  Selective and divided attention during visual discriminations of shape, color, and speed: functional anatomy by positron emission tomography , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[33]  A. Cormack.  Representation of a Function by Its Line Integrals, with Some Radiological Applications , 1963 .

[34]  P T Fox.  Functional brain mapping with positron emission tomography. , 1989, Seminars in neurology.

[35]  R. Trebossen,et al.  Physical characteristics of the ECAT 953B/31: a new high resolution brain positron tomograph , 1991 .

[36]  J. Mazziotta,et al.  Positron emission tomography study of human brain functional development , 1987, Annals of neurology.

[37]  Karl J. Friston,et al.  Comparing Functional (PET) Images: The Assessment of Significant Change , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[38]  M. Mintun,et al.  Enhanced Detection of Focal Brain Responses Using Intersubject Averaging and Change-Distribution Analysis of Subtracted PET Images , 1988, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[39]  N. Geschwind,et al.  Human Brain: Left-Right Asymmetries in Temporal Speech Region , 1968, Science.

[40]  S J Gatley,et al.  Sensitivity of measurements of regional brain activation with oxygen-15-water and PET to time of stimulation and period of image reconstruction. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[41]  E. Hoffman,et al.  Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method , 1979, Annals of neurology.

[42]  J. Fike,et al.  Measurement of regional cerebral blood flow using ultrafast computed tomography. Theoretical aspects. , 1991, Stroke.

[43]  M. Posner,et al.  Localization of cognitive operations in the human brain. , 1988, Science.

[44]  I. Kanno,et al.  Optimal scan time of oxygen-15-labeled water injection method for measurement of cerebral blood flow. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[45]  M. Raichle,et al.  Stimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomography. , 1984, Journal of neurophysiology.

[46]  J C Mazziotta,et al.  Somatotopic mapping of the primary motor cortex in humans: activation studies with cerebral blood flow and positron emission tomography. , 1991, Journal of neurophysiology.

[47]  A S Gevins,et al.  Human neuroelectric patterns predict performance accuracy. , 1987, Science.

[48]  A Piepsz,et al.  Functional imaging of brain maturation in humans using iodine-123 iodoamphetamine and SPECT. , 1989, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[49]  Karl J. Friston,et al.  A direct demonstration of functional specialization in human visual cortex , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[50]  Karl J. Friston,et al.  The Relationship between Global and Local Changes in PET Scans , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[51]  Christoph Segebarth,et al.  Mapping of normal brain maturation in infants on phase-sensitive inversion-recovery MR images , 2004, Neuroradiology.

[52]  K Herholz,et al.  Three-dimensional alignment of functional and morphological tomograms. , 1990, Journal of computer assisted tomography.

[53]  W. T. Thach,et al.  Functional mapping of the human cerebellum with positron emission tomography. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[54]  T F Budinger,et al.  PHYSICAL ATTRIBUTES OF SINGLE‐PHOTON TOMOGRAPHY , 1980, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[55]  J. Allman,et al.  Mapping human visual cortex with positron emission tomography , 1986, Nature.

[56]  K. D. Singh,et al.  Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[57]  D. S. Williams,et al.  Magnetic resonance imaging of perfusion using spin inversion of arterial water. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Alan C. Evans,et al.  Lateralization of phonetic and pitch discrimination in speech processing. , 1992, Science.

[59]  R D Penn,et al.  Brain Maturation Followed by Computed Tomography , 1980, Journal of computer assisted tomography.