15O water positron emission tomography in language localization: A study comparing positron emission tomography visual and computerized region of interest analysis with the wada test

We compared 15O water positron emission tomography (PET) auditory and visual confrontational naming activation with an intracarotid amobarbital (Amytal) injection procedure (IAP) for language lateralization in 12 patients with intractable epilepsy. PET scans were evaluated by three raters experienced in functional imaging as well as by a region of interest (ROI) approach. Compared with IAP, raters' positive predictive value for language lateralization ranged from 88 to 91%. ROI analysis had a positive predictive value of 80%. Six patients had surgery; 1 with right‐sided IAP language dominance but left‐sided PET activation had dysphasia for 6 months after left temporal lobectomy. Ann Neurol 1999;45:662–665

[1]  D. Le Bihan,et al.  Noninvasive assessment of language dominance in children and adolescents with functional MRI , 1997, Neurology.

[2]  J. B. Demb,et al.  Functional MRI measurement of language lateralization in Wada-tested patients. , 1995, Brain : a journal of neurology.

[3]  J. A. Frost,et al.  Determination of language dominance using functional MRI , 1996, Neurology.

[4]  G A Ojemann,et al.  Individual variability in cortical localization of language. , 1979, Journal of neurosurgery.

[5]  R. Seitz,et al.  Functional anatomy of language processing: Neuroimaging and the problem of individual variability , 1991, Neuropsychologia.

[6]  C B Dodrill,et al.  Brain injury, handedness, and speech lateralization in a series of amobarbital studies , 1988, Annals of neurology.

[7]  W H Theodore,et al.  Cortical Stimulation Elicits Regional Distinctions in Auditory and Visual Naming , 1996, Epilepsia.

[8]  Karl J. Friston,et al.  Distribution of cortical neural networks involved in word comprehension and word retrieval. , 1991, Brain : a journal of neurology.

[9]  O. Devinsky,et al.  Anterior temporal language areas in patients with early onset of temporal lobe epilepsy , 1993, Annals of neurology.

[10]  Objective criteria for reporting language dominance by intracarotid amobarbital procedure. , 1995, Journal of clinical and experimental neuropsychology.

[11]  E. Reiman,et al.  Use of positron emission tomography for presurgical localization of eloquent brain areas in children with seizures. , 1997, Pediatric neurosurgery.

[12]  Karl J. Friston,et al.  The cortical localization of the lexicons. Positron emission tomography evidence. , 1992, Brain : a journal of neurology.

[13]  Peter T. Fox,et al.  Preoperative assessment of the cerebral hemispheric dominance for language with CBF PET , 1993 .

[14]  T. Hammeke,et al.  Functional Magnetic Resonance Imaging in Partial Epilepsy , 1994, Epilepsia.

[15]  R P Lesser,et al.  Cognitive Effects of Resecting Basal Temporal Language Areas , 1996, Epilepsia.

[16]  W H Theodore,et al.  A direct comparison of PET activation and electrocortical stimulation mapping for language localization , 1997, Neurology.

[17]  P. T. Fox,et al.  Positron emission tomographic studies of the cortical anatomy of single-word processing , 1988, Nature.