We report preliminary results of an Advanced Satellite for Cosmology and Astrophysics (ASCA) observation of 3C 273. There is no spectral variability within the ASCA observation, in contrast to the longer term behavior found with European X-ray Observatory Satellite (EXOSAT) and Ginga which established significant changes in the spectral index of the power-law continuum on timescales of a week or more, uncorrelated with luminosity. Comparison of the ASCA data with a simultaneous Roentgen Satellite (ROSAT) Ginga observation in 1990 December shows that while the shape of the spectrum above approximately 1 keV is essentially the same, the flux in the soft component, below approximately 1 keV, considerably weaker relative to the hard component in the ASCA observation. The 2-10 keV luminosity is at least a factor of approximately 1.5 greater in the ASCA observation than in the ROSAT/Ginga observation while the ratio of 2-10 keV luminosity to 0.4-1.0 keV luminosity increases by a factor of approximately 1.2. Thus the spectral shape of the hard component appears to be independent of the relative magnitude of the soft component and is an important constraint on emission and reprocessing models. We find no significant Fe K line-emission in this observation. The data also highlight very well some of the outstanding problems in the instrumental responses.