Corpus callosum diffusion anisotropy correlates with neuropsychological outcomes in twins disconcordant for traumatic brain injury.

Conventional and diffusion tensor MR imaging studies in twins sustaining severe pediatric traumatic brain injury identified reduction in fractional anisotropy (FA) in all regions of the corpus callosum, particularly the posterior body, rostral body, and genu, relative to healthy cotwins. FA from the rostrum, genu, anterior body, posterior body, and isthmus were correlated with measures of reading speed and comprehension; verbal working memory and math fact retrieval scores were correlated only with the rostral body FA.

[1]  S. F. Witelson.  Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study. , 1989, Brain : a journal of neurology.

[2]  Ron Dumont,et al.  Woodcock‐Johnson III Tests of Achievement , 2008 .

[3]  H S Levin,et al.  Reduction of corpus callosum growth after severe traumatic brain injury in children , 2000, Neurology.

[4]  Jacob Cohen.  Statistical Power Analysis for the Behavioral Sciences , 1969, The SAGE Encyclopedia of Research Design.

[5]  G J Barker,et al.  Diffusion imaging shows abnormalities after blunt head trauma when conventional magnetic resonance imaging is normal , 2001, Journal of neurology, neurosurgery, and psychiatry.

[6]  V. Haughton,et al.  Diffusion tensor MR imaging in diffuse axonal injury. , 2002, AJNR. American journal of neuroradiology.

[7]  J. Fletcher,et al.  Brain mechanisms for reading words and pseudowords: an integrated approach. , 2002, Cerebral cortex.

[8]  Joseph A Maldjian,et al.  Diffusion anisotropy in the corpus callosum. , 2002, AJNR. American journal of neuroradiology.

[9]  Vinod Menon,et al.  Prefrontal cortex involvement in processing incorrect arithmetic equations: Evidence from event‐related fMRI , 2002, Human brain mapping.

[10]  C. A. Rashotte,et al.  Test of Word Reading Efficiency , 1999 .

[11]  Weijia Ni,et al.  Sentence complexity and input modality effects in sentence comprehension: an fMRI study , 2004, NeuroImage.

[12]  S. Strich.  Lesions in the cerebral hemispheres after blunt head injury. , 1970, Journal of clinical pathology. Supplement.

[13]  A L Reiss,et al.  Corpus callosum morphology in children with Tourette syndrome and attention deficit hyperactivity disorder , 1996, Neurology.

[14]  Khader M Hasan,et al.  Computation of the fractional anisotropy and mean diffusivity maps without tensor decoding and diagonalization: Theoretical analysis and validation , 2003, Magnetic resonance in medicine.

[15]  Alan Richards Moritz,et al.  The pathology of trauma , 1973 .

[16]  A. Sorensen,et al.  Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. , 2004, AJNR. American journal of neuroradiology.

[17]  P. Carpenter,et al.  Individual differences in working memory and reading , 1980 .