Structural Topology Optimization Method Based on Bone Remodeling

Bone is a dynamic living tissue that undergoes continuous adaptation of its mass and structure in response to mechanical and biological environment demands. In this paper, we firstly propose a mathematical model based on cross-type reaction diffusion equations of bone adaptation during a remodeling cycle due to mechanical stimulus. The model captures qualitatively very well the bone adaptation and cell interactions during the bone remodeling. Secondly assuming the bone structure to be a self-optimizing biological material which maximizes its own structural stiffness, bone remodeling model coupled with finite element method by using the add and remove element a new topology optimization of continuum structure is presented. Two Numerical examples demonstrate that the proposed approach greatly improves numerical efficiency, compared with the others well known methods for structural topology optimization in open literatures.

[1]  Z. Kang,et al.  Continuum topology optimization with non-probabilistic reliability constraints based on multi-ellipsoid convex model , 2009 .

[2]  A. M. Turing,et al.  The chemical basis of morphogenesis , 1952, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

[3]  Masanori Kikuchi,et al.  Bone Formation Based on the Turing Model under Compressed Loading Condition , 2008 .

[4]  K. Tezuka,et al.  Stimulation of Osteoblastic Cell Differentiation by Notch , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[5]  Saeed Shojaee,et al.  Structural topology optimization using ant colony methodology , 2008 .

[6]  Yi Min Xie,et al.  Evolutionary Topology Optimization of Continuum Structures: Methods and Applications , 2010 .

[7]  Mamtimin Gheni,et al.  Study on Self-Consistent Mesh Generating Method of Hexahedron Element Based on the Local Waveform Method with Damping , 2006 .

[8]  S. Kondo,et al.  A reaction–diffusion wave on the skin of the marine angelfish Pomacanthus , 1995, Nature.

[9]  Yoshitaka Wada,et al.  Computer-simulated bone architecture in a simple bone-remodeling model based on a reaction-diffusion system , 2004, Journal of Bone and Mineral Metabolism.

[10]  Philip K Maini,et al.  Periodic pattern formation in reaction—diffusion systems: An introduction for numerical simulation , 2004, Anatomical science international.

[11]  Liping Chen,et al.  A semi-implicit level set method for structural shape and topology optimization , 2008, J. Comput. Phys..

[12]  Rik Huiskes,et al.  Effects of mechanical forces on maintenance and adaptation of form in trabecular bone , 2000, Nature.

[13]  A. Turing The chemical basis of morphogenesis , 1952, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

[14]  Yoshitaka Wada,et al.  iBone: A Reaction Diffusion Based Shape Optimization Method , 2003 .

[15]  Mamtimin Gheni,et al.  Shape Optimization of Metal Welded Bellows Seal Based on the Turing Reaction-Diffusion Model Coupled with FEM , 2008 .