Importance of Hyaluronan-CD44 Interactions in Inflammation and Tumorigenesis

Hyaluronan is an apparently simple polysaccharide that is responsible for tissue hydration but also stimulates cell proliferation, migration, and differentiation via binding to cell surface receptors, such as CD44. The amounts of hyaluronan increase during inflammation and tumorigenesis through the action of chemokines and growth factors. This review discusses some of the evidence that hyaluronan-CD44 complexes trigger signaling cascades that modulate inflammation and tumor progression.

[1]  P. Heldin,et al.  Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells , 2007, International journal of cancer.

[2]  M. Bissell.  Modelling molecular mechanisms of breast cancer and invasion: lessons from the normal gland. , 2007, Biochemical Society transactions.

[3]  M. Götte,et al.  Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective. , 2006, Cancer research.

[4]  C. Heldin,et al.  Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44* , 2006, Journal of Biological Chemistry.

[5]  P. Johnston,et al.  The emerging role of CD44 in regulating skeletal micrometastasis. , 2006, Cancer letters.

[6]  M. J. Jedrzejas,et al.  Hyaluronidases: their genomics, structures, and mechanisms of action. , 2006, Chemical reviews.

[7]  A. Moustakas,et al.  Hyaluronan Fragments Induce Endothelial Cell Differentiation in a CD44- and CXCL1/GRO1-dependent Manner*boxs , 2005, Journal of Biological Chemistry.

[8]  S. Ghatak,et al.  Hyaluronan Constitutively Regulates ErbB2 Phosphorylation and Signaling Complex Formation in Carcinoma Cells* , 2005, Journal of Biological Chemistry.

[9]  H. Saya,et al.  Mechanism and biological significance of CD44 cleavage , 2004, Cancer science.

[10]  R. Hollingsworth,et al.  CD44 modulates Smad1 activation in the BMP-7 signaling pathway , 2004, The Journal of cell biology.

[11]  B. Toole,et al.  Hyaluronan: from extracellular glue to pericellular cue , 2004, Nature Reviews Cancer.

[12]  R. B. Campbell,et al.  Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors , 2004, Nature Medicine.

[13]  E. Puré,et al.  The liberation of CD44 , 2003, The Journal of cell biology.

[14]  Gerhard Christofori,et al.  Changing neighbours, changing behaviour: cell adhesion molecule‐mediated signalling during tumour progression , 2003, The EMBO journal.

[15]  P. Herrlich,et al.  CD44: From adhesion molecules to signalling regulators , 2003, Nature Reviews Molecular Cell Biology.

[16]  M. Rahmanian,et al.  Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors , 2002, International journal of cancer.

[17]  E. Puré,et al.  Resolution of Lung Inflammation by CD44 , 2002, Science.

[18]  Lilly Y. W. Bourguignon,et al.  Signaling Properties of Hyaluronan Receptors* , 2002, The Journal of Biological Chemistry.

[19]  P. Heldin,et al.  Hyaluronan production increases the malignant properties of mesothelioma cells , 2001, British Journal of Cancer.

[20]  E. Puré,et al.  A crucial role for CD44 in inflammation. , 2001, Trends in molecular medicine.

[21]  M. Rahmanian,et al.  Irradiation-induced expression of hyaluronan (HA) synthase 2 and hyaluronidase 2 genes in rat lung tissue accompanies active turnover of HA and induction of types I and III collagen gene expression. , 2000, American journal of respiratory cell and molecular biology.

[22]  P. Heldin,et al.  Expression of human hyaluronan synthases in response to external stimuli. , 2000, The Biochemical journal.

[23]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[24]  M Tammi,et al.  Hyaluronan synthases. , 1997, The Journal of biological chemistry.

[25]  J. Bergh,et al.  Differential synthesis and binding of hyaluronan by human breast cancer cell lines. , 1996, Oncology reports.