The envelope following response: Scalp potentials elicited in the mongolian gerbil using sinusoidally AM acoustic signals

Scalp potentials which follow the low frequency envelope of a sinusoidally amplitude modulated stimulus waveform were evoked and recorded in anesthetized gerbils. This envelope following response (EFR) is presumably due to the synchronized discharge of populations of neurons in the auditory pathway. The magnitude of the EFR increased and the latency decreased in a near monotonic fashion with increased stimulus intensity and modulation depth. The modulation rate transfer function (MRTF) was determined for modulation frequencies between 10 and 920 Hz imposed on carrier frequencies ranging from 1 to 7 kHz. The MRTF was low pass in character having a corner frequency of 100-120 Hz. Measurements of the group delay, determined from the phase of the response relative to the stimulus phase, indicate that the response is generated in at least three distinct regions within the auditory pathway.

[1]  G M Clark,et al.  Steady-state evoked potentials to amplitude modulated tones in the monkey. , 1992, Acta oto-laryngologica.

[2]  Robert L. Smith,et al.  Development of mature microcystic lesions in the cochlear nuclei of the mongolian gerbil, Meriones unguiculatus , 1990, Hearing Research.

[3]  R. Batra,et al.  Temporal coding of envelopes and their interaural delays in the inferior colliculus of the unanesthetized rabbit. , 1989, Journal of neurophysiology.

[4]  Shigeyuki Kuwada,et al.  Scalp potentials of normal and hearing-impaired subjects in response to sinusoidally amplitude-modulated tones , 1986, Hearing Research.

[5]  A. Ryan,et al.  Hearing sensitivity of the mongolian gerbil, Meriones unguiculatis. , 1976, The Journal of the Acoustical Society of America.

[6]  Adrian Rees,et al.  Stimulus properties influencing the responses of inferior colliculus neurons to amplitude-modulated sounds , 1987, Hearing Research.

[7]  J. E. Rose,et al.  Phase-locked response to low-frequency tones in single auditory nerve fibers of the squirrel monkey. , 1967, Journal of neurophysiology.

[8]  Robert D Frisina,et al.  Encoding of amplitude modulation in the gerbil cochlear nucleus: I. A hierarchy of enhancement , 1990, Hearing Research.

[9]  R. Galamboš,et al.  Brain stem auditory evoked responses in human infants and adults. , 1974, Archives of otolaryngology.

[10]  Scalp potentials follow the low frequency envelope of complex acoustic stimuli , 1991, Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference.

[11]  H. W. Bode,et al.  Network analysis and feedback amplifier design , 1945 .

[12]  Adrian Rees,et al.  Dynamic properties of the responses of single neurons in the inferior colliculus of the rat , 1986, Hearing Research.

[13]  A. Møller Responses of units in the cochlear nucleus to sinusoidally amplitude-modulated tones. , 1974, Experimental neurology.

[14]  R. Burkard,et al.  Comments on "Stimulus dependencies of the gerbil brain-stem auditory-evoked response (BAER). I: Effects of click level, rate and polarity" [J. Acoust. Soc. Am. 85, 2514-2525 (1989)]. , 1993, The Journal of the Acoustical Society of America.

[15]  J. T. Marsh,et al.  Differential brainstem pathways for the conduction of auditory frequency-following responses. , 1974, Electroencephalography and clinical neurophysiology.

[16]  A. Palmer,et al.  Phase-locking in the cochlear nerve of the guinea-pig and its relation to the receptor potential of inner hair-cells , 1986, Hearing Research.

[17]  Shigeyuki Kuwada,et al.  The frequency-following response to continuous tones in humans , 1986, Hearing Research.

[18]  B. M. Johnstone,et al.  Group delay measurement from spiral ganglion cells in the basal turn of the guinea pig cochlea. , 1984, The Journal of the Acoustical Society of America.

[19]  A. Møller,et al.  Coding of amplitude and frequency modulated sounds in the cochlear nucleus of the rat. , 1972, Acta physiologica Scandinavica.

[20]  J. Stockard,et al.  Brainstem auditory-evoked responses. Normal variation as a function of stimulus and subject characteristics. , 1979, Archives of neurology.

[21]  J. Allen Cochlear micromechanics--a mechanism for transforming mechanical to neural tuning within the cochlea. , 1977, The Journal of the Acoustical Society of America.

[22]  A. Starr,et al.  Auditory brain stem responses in neurological disease. , 1975, Archives of neurology.

[23]  M. Rodenburg,et al.  Analysis of evoked responses in man elicited by sinusoidally modulated noise. , 1972, Audiology : official organ of the International Society of Audiology.

[24]  J. Hall Auditory brainstem frequency following responses to waveform envelope periodicity. , 1979, Science.

[25]  N. Viemeister Temporal modulation transfer functions based upon modulation thresholds. , 1979, The Journal of the Acoustical Society of America.

[26]  G Moushegian,et al.  Laboratory note. Scalp-recorded early responses in man to frequencies in the speech range. , 1973, Electroencephalography and clinical neurophysiology.

[27]  K. Hecox,et al.  Effect of broadband noise on the human brain stem auditory evoked response. , 1989, Ear and hearing.

[28]  Adrian Rees,et al.  Responses of neurons in the inferior colliculus of the rat to AM and FM tones , 1983, Hearing Research.

[29]  Easy Access to the Auditory Nerve in the Mongolian Gerbil , 1973 .

[30]  George Moushegian,et al.  Laboratory noteScalp-recorded early responses in man to frequencies in the speech rangeReponses precoces enregistrees sur le scalp chez l'homme a des frequences dans la gamme du langage , 1973 .

[31]  David J. Anderson,et al.  Temporal Position of Discharges in Single Auditory Nerve Fibers within the Cycle of a Sine‐Wave Stimulus: Frequency and Intensity Effects , 1971 .

[32]  Alan V. Oppenheim,et al.  Discrete-Time Signal Pro-cessing , 1989 .

[33]  A. Ryan,et al.  Neural phase-locking properties in the absence of cochlear outer hair cells , 1981, Hearing Research.

[34]  R. Burkard,et al.  The effect of broadband noise on the human brainstem auditory evoked response. I. Rate and intensity effects. , 1983, The Journal of the Acoustical Society of America.

[35]  T. Yin,et al.  Interaural time sensitivity of high-frequency neurons in the inferior colliculus. , 1984, The Journal of the Acoustical Society of America.

[36]  C. Schreiner,et al.  Temporal Resolution of Amplitude Modulation and Complex Signals in the Auditory Cortex of the Cat , 1938 .

[37]  A. Salamy,et al.  Scalp-recorded frequency-following responses in neonates. , 1979, Audiology : official organ of the International Society of Audiology.

[38]  E. Ostapoff,et al.  A degenerative disorder of the central auditory system of the gerbil , 1989, Hearing Research.

[39]  A. Rees,et al.  Steady-state evoked responses to sinusoidally amplitude-modulated sounds recorded in man , 1986, Hearing Research.

[40]  R. Burkard,et al.  Stimulus dependencies of the gerbil brain-stem auditory-evoked response (BAER). I: Effects of click level, rate, and polarity. , 1989, The Journal of the Acoustical Society of America.

[41]  R. Frisina,et al.  Anatomy and physiology of the gerbil cochlear nucleus: An improved surgical approach for microelectrode studies , 1982, Hearing Research.

[42]  D L Jewett,et al.  Volume-conducted potentials in response to auditory stimuli as detected by averaging in the cat. , 1970, Electroencephalography and clinical neurophysiology.