Prevalence of bloodborne infective agents among people admitted to a Canadian hospital.

OBJECTIVE To determine the prevalence rates of hepatitis B surface antigen (HBsAg) and antibodies to the human immunodeficiency virus (anti-HIV) and the hepatitis C virus (anti-HCV) among people admitted to an urban Canadian hospital. DESIGN Anonymous unlinked serosurvey. SETTING A 420-bed teaching hospital in Toronto. PARTICIPANTS All 3000 patients admitted to the hospital on weekdays from January to June 1990. An attempt was made to exclude those who were readmitted during the study period. INTERVENTIONS Serum samples from all the patients were tested for HBsAg and anti-HIV, and 1306 samples were also tested for anti-HCV by means of enzyme immunosorbent assays; reactions were confirmed by means of specific antibody neutralization or immunoblot assay. MAIN RESULTS The prevalence rates of HBsAg, anti-HIV and anti-HCV were 2.1% (95% confidence interval [CI] 1.6% to 2.6%), 0.6% (95% CI 0.3% to 0.9%) and 0.5% (95% CI 0.1% to 0.9%) respectively. CONCLUSIONS This is the first report defining rates of infection with these bloodborne agents among patients admitted to a Canadian hospital. The observed rates likely reflect the patient population served by our hospital and do not necessarily apply to other Canadian centres. The results support the use of universal precautions in health care settings.

[1]  R. Chaudhary,et al.  Antibody to hepatitis C virus in risk groups in Canada. , 1990, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

[2]  R. Purcell,et al.  Hepatitis C in hospital employees with needlestick injuries. , 1991, Annals of internal medicine.

[3]  D Coburn,et al.  Guidelines on ethical and legal considerations in anonymous unlinked HIV seroprevalence research. , 1991, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[4]  A. Alberti.  Diagnosis of hepatitis C. Facts and perspectives. , 1991, Journal of hepatology.

[5]  R. Coates,et al.  Comparison of saliva and blood for human immunodeficiency virus prevalence testing. , 1991, The Journal of infectious diseases.

[6]  P. Walker,et al.  Clinical laboratory scientists' attitudes toward HIV testing in hospital environments , 1991 .

[7]  H. Lane,et al.  Risk for occupational transmission of human immunodeficiency virus type 1 (HIV-1) associated with clinical exposures. A prospective evaluation. , 1990, Annals of internal medicine.

[8]  J. Gerberding.  Current epidemiologic evidence and case reports of occupationally acquired HIV and other bloodborne diseases. , 1990, Infection control and hospital epidemiology.

[9]  L. Petersen,et al.  Seroprevalence Rates of Human Immunodeficiency Virus Infection at Sentinel Hospitals in the United States , 1990 .

[10]  C. Gibert,et al.  Prevalence of human immunodeficiency virus and hepatitis B virus in unselected hospital admissions: implications for mandatory testing and universal precautions. , 1990, The Journal of infectious diseases.

[11]  D. Maki,et al.  The case for wider use of testing for HIV infection. , 1989, The New England journal of medicine.

[12]  Universal precautions. Report of a Consensus Committee Meeting. , 1989, Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada.

[13]  R. Brookmeyer,et al.  Unrecognized human immunodeficiency virus infection in emergency department patients. , 1988, The New England journal of medicine.

[14]  A. Washington,et al.  Cost-effectiveness of prenatal screening and immunization for hepatitis B virus. , 1988, JAMA.

[15]  Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings. , 1988, New York state journal of medicine.

[16]  M. Alter,et al.  Sporadic non-A, non-B hepatitis: frequency and epidemiology in an urban U.S. population. , 1982, The Journal of infectious diseases.

[17]  B. Berris,et al.  Prevalence and significance of hepatitis B surface antigen in a general hospital. , 1975, Canadian Medical Association journal.