Genetic evidence for a tumor suppressor role of HIF-2alpha.

[1]  Patrick H. Maxwell,et al.  Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma , 2005, Molecular and Cellular Biology.

[2]  W. Kaelin,et al.  Proline hydroxylation and gene expression. , 2005, Annual review of biochemistry.

[3]  M. Simon,et al.  Decreased Growth of Vhl−/− Fibrosarcomas Is Associated with Elevated Levels of Cyclin Kinase Inhibitors p21 and p27 , 2005, Molecular and Cellular Biology.

[4]  A. Harris,et al.  The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway. , 2005, Cancer research.

[5]  P. Bonnier,et al.  Overexpression of hypoxia‐inducible factor HIF‐1α predicts early relapse in breast cancer: Retrospective study in a series of 745 patients , 2005, International journal of cancer.

[6]  W. Poon,et al.  Glioblastoma cells deficient in DNA‐dependent protein kinase are resistant to cell death , 2005, Journal of cellular physiology.

[7]  A. Harris,et al.  HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression , 2005 .

[8]  Brian Keith,et al.  Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth. , 2005, Cancer research.

[9]  M. Tachibana,et al.  Prognostic Impact of Hypoxia-Inducible Factors 1α and 2α in Colorectal Cancer Patients , 2004, Clinical Cancer Research.

[10]  L. Turka,et al.  Vhlh Gene Deletion Induces Hif-1-Mediated Cell Death in Thymocytes , 2004, Molecular and Cellular Biology.

[11]  R. Shoemaker,et al.  Schedule-dependent Inhibition of Hypoxia-inducible Factor-1α Protein Accumulation, Angiogenesis, and Tumor Growth by Topotecan in U251-HRE Glioblastoma Xenografts , 2004, Cancer Research.

[12]  E. Wall,et al.  The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis , 2004, Journal of Clinical Pathology.

[13]  Till Acker,et al.  Cellular oxygen sensing need in CNS function: physiological and pathological implications , 2004, Journal of Experimental Biology.

[14]  L. Huang,et al.  Dynamic Balancing of the Dual Nature of HIF-1alpha for Cell Survival , 2004, Cell cycle.

[15]  D. Livingston,et al.  Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. , 2004, Cancer cell.

[16]  L. Gunaratnam,et al.  HIF activation by pH-dependent nucleolar sequestration of VHL , 2004, Nature Cell Biology.

[17]  Y. Pan,et al.  p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment , 2004, Oncogene.

[18]  L. Ellis,et al.  Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. , 2004, Journal of the National Cancer Institute.

[19]  M. Simon,et al.  Regulation of Transcription and Translation by Hypoxia , 2004, Cancer biology & therapy.

[20]  L. Huang,et al.  HIF‐1α induces cell cycle arrest by functionally counteracting Myc , 2004 .

[21]  Christopher J. Schofield,et al.  Oxygen sensing by HIF hydroxylases , 2004, Nature Reviews Molecular Cell Biology.

[22]  O. Iliopoulos,et al.  Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. , 2004, Molecular cancer research : MCR.

[23]  L. Poellinger,et al.  HIF-1 and hypoxic response: the plot thickens. , 2004, Current opinion in genetics & development.

[24]  P. Maxwell,et al.  HIF-1, An Oxygen and Metal Responsive Transcription Factor , 2004, Cancer biology & therapy.

[25]  W. Kaelin,et al.  Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth , 2003, PLoS biology.

[26]  Kan Ding,et al.  Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice , 2003, Nature Genetics.

[27]  P. Carmeliet,et al.  Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. , 2003, Cardiovascular research.

[28]  A. Giaccia,et al.  HIF-1 as a target for drug development , 2003, Nature Reviews Drug Discovery.

[29]  G. Semenza.  Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.

[30]  A. Harris,et al.  Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. , 2003, Cancer research.

[31]  J. Pouysségur,et al.  HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia , 2003, The EMBO journal.

[32]  Tarik Tihan,et al.  The hypoxic response of tumors is dependent on their microenvironment. , 2003, Cancer cell.

[33]  R. Pötter,et al.  Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[34]  J. Simons,et al.  2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. , 2003, Cancer cell.

[35]  N. Tamaki,et al.  Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. , 2003, The American journal of pathology.

[36]  Till Acker,et al.  Cooperative Interaction of Hypoxia-inducible Factor-2α (HIF-2α) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1)* , 2003, The Journal of Biological Chemistry.

[37]  J. Gnarra,et al.  Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. , 2003, Cancer cell.

[38]  Till Acker,et al.  Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice , 2002, Nature Medicine.

[39]  A. Harris,et al.  Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. , 2002, Cancer research.

[40]  Mirna Lechpammer,et al.  Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. , 2002, Cancer cell.

[41]  G. Semenza,et al.  HIF-1 and tumor progression: pathophysiology and therapeutics. , 2002, Trends in molecular medicine.

[42]  Richard D Klausner,et al.  The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. , 2002, Cancer cell.

[43]  T Kobayashi,et al.  Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. , 2001, Genes & development.

[44]  P. Carmeliet,et al.  Hypoxia-inducible Factor-2α (HIF-2α) Is Involved in the Apoptotic Response to Hypoglycemia but Not to Hypoxia* , 2001, The Journal of Biological Chemistry.

[45]  A. Harris,et al.  Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival , 2001, British Journal of Cancer.

[46]  R. B. Campbell,et al.  In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy , 2001, Nature Medicine.

[47]  A. Harris,et al.  Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[48]  K. Kihara,et al.  Regulation of vascular endothelial growth factor transcription by endothelial PAS domain protein 1 (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renal cell carcinoma , 2001, Cancer.

[49]  P. Carmeliet,et al.  Heterogeneous vascular dependence of tumor cell populations. , 2001, The American journal of pathology.

[50]  F. Ismail-Beigi,et al.  Regulation of glut1 mRNA by Hypoxia-inducible Factor-1 , 2001, The Journal of Biological Chemistry.

[51]  A. Harris,et al.  Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. , 2000, Cancer research.

[52]  Andrew L. Kung,et al.  Suppression of tumor growth through disruption of hypoxia-inducible transcription , 2000, Nature Medicine.

[53]  P. Ratcliffe,et al.  Targeting tumors through the HIF system , 2000, Nature Medicine.

[54]  Till Acker,et al.  Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function , 2000, Oncogene.

[55]  R K Jain,et al.  Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors. , 2000, Cancer research.

[56]  A. Harris,et al.  The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages , 2000 .

[57]  J. M. Arbeit,et al.  Hypoxia-inducible Factor-1α Is a Positive Factor in Solid Tumor Growth , 2000 .

[58]  J. Peng,et al.  The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[59]  M. Volm,et al.  Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. , 2000, Anticancer research.

[60]  G. Semenza,et al.  Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. , 2000, Cancer research.

[61]  R. Hammer,et al.  The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. , 1998, Genes & development.

[62]  A. Harris,et al.  Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. , 1998, Blood.

[63]  P. Carmeliet,et al.  Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis , 1998, Nature.

[64]  K. Plate,et al.  Up-Regulation of Vascular Endothelial Growth Factor in Stromal Cells of Hemangioblastomas Is Correlated with Up-Regulation of the Transcription Factor HRF/HIF-2α , 1998 .

[65]  Jessica Lo,et al.  HIF‐1α is required for solid tumor formation and embryonic vascularization , 1998 .

[66]  D. Fisher,et al.  Regulation of Proliferation-Survival Decisions during Tumor Cell Hypoxia , 1998, Molecular and Cellular Biology.

[67]  M. Gassmann,et al.  Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. , 1998, Genes & development.

[68]  W. Risau,et al.  Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells. , 1997, The Biochemical journal.

[69]  David Baunoch,et al.  Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT , 1997, Nature.

[70]  Lieve Moons,et al.  Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele , 1996, Nature.

[71]  David E. Housman,et al.  Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours , 1996, Nature.

[72]  E. Pettersen,et al.  Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: the possible role of cell cycle arrest as a protection against hypoxia‐induced lethal damage , 1991, Cell proliferation.