Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling

[1]  Yi Wang,et al.  Scalable molecular dynamics on CPU and GPU architectures with NAMD. , 2020, The Journal of chemical physics.

[2]  J. Pihlajamäki,et al.  LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover , 2020, Gut.

[3]  H. Yabushita,et al.  Prediction of binding characteristics between von Willebrand factor and platelet glycoprotein Ibα with various mutations by molecular dynamic simulation. , 2019, Thrombosis research.

[4]  M. Arita,et al.  Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis. , 2019, International immunology.

[5]  H. Arai,et al.  Platelet-activating factor acetylhydrolases: An overview and update. , 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[6]  M. Humbert,et al.  Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives , 2019, European Respiratory Journal.

[7]  T. Desai,et al.  Pro-resolving lipid mediators in vascular disease. , 2018, The Journal of clinical investigation.

[8]  Z. Jing,et al.  Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice , 2018, The Journal of experimental medicine.

[9]  M. Ikeguchi,et al.  Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid , 2018, Scientific Reports.

[10]  Torsten Schwede,et al.  SWISS-MODEL: homology modelling of protein structures and complexes , 2018, Nucleic Acids Res..

[11]  Henning Gall,et al.  Identification of rare sequence variation underlying heritable pulmonary arterial hypertension , 2018, Nature Communications.

[12]  M. Ishii,et al.  The 17,18‐epoxyeicosatetraenoic acid–G protein–coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques , 2017, The Journal of allergy and clinical immunology.

[13]  Jun Yang,et al.  Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling , 2017, Proceedings of the National Academy of Sciences.

[14]  H. Kusuhara,et al.  Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation , 2017, Nature Medicine.

[15]  Masatoshi Kondo,et al.  Mast cell hyperactivity underpins the development of oxygen-induced retinopathy , 2017, The Journal of clinical investigation.

[16]  Jonathan R M Millet,et al.  Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling. , 2017, Cell reports.

[17]  M. Humbert,et al.  Epidemiology and treatment of pulmonary arterial hypertension , 2017, Nature Reviews Cardiology.

[18]  R. Pearsall,et al.  A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension. , 2016, American journal of respiratory and critical care medicine.

[19]  P. Bradding,et al.  New Developments in Mast Cell Biology: Clinical Implications. , 2016, Chest.

[20]  Yechun Xu,et al.  Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors. , 2016, Journal of medicinal chemistry.

[21]  N. Voelkel,et al.  Leukotriene B4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension , 2015, Hypertension.

[22]  Makoto Arita,et al.  Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut , 2015, Scientific Reports.

[23]  S. Hwang,et al.  Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides , 2014, Proceedings of the National Academy of Sciences.

[24]  K. Fukuda,et al.  18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling , 2014, The Journal of experimental medicine.

[25]  Charles N. Serhan,et al.  Pro-resolving lipid mediators are leads for resolution physiology , 2014, Nature.

[26]  J. Shendure,et al.  A general framework for estimating the relative pathogenicity of human genetic variants , 2014, Nature Genetics.

[27]  L. Farkas,et al.  Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension , 2013, Science Translational Medicine.

[28]  Hau D. Le,et al.  Epoxyeicosanoids promote organ and tissue regeneration , 2013, Proceedings of the National Academy of Sciences.

[29]  S. Hwang,et al.  Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis , 2013, Proceedings of the National Academy of Sciences.

[30]  R. Rosenson,et al.  Phospholipase A2 enzymes and the risk of atherosclerosis. , 2012, European heart journal.

[31]  S. Groshong,et al.  Modern age pathology of pulmonary arterial hypertension. , 2012, American journal of respiratory and critical care medicine.

[32]  H. Hammad,et al.  C-kit-positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension. , 2011, American journal of respiratory and critical care medicine.

[33]  B. Dahal,et al.  Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats , 2011, Respiratory research.

[34]  W. Kuebler,et al.  Mast cells promote lung vascular remodelling in pulmonary hypertension , 2010, European Respiratory Journal.

[35]  Jianpeng Ma,et al.  CHARMM: The biomolecular simulation program , 2009, J. Comput. Chem..

[36]  A. Wolk,et al.  Fish consumption, marine omega-3 fatty acids, and incidence of heart failure: a population-based prospective study of middle-aged and elderly men. , 2009, European heart journal.

[37]  D. Stafforini,et al.  The emerging roles of PAF acetylhydrolase This work was supported by National Institutes of Health Grants HL44513, HL35828, and HL087018. Published, JLR Papers in Press, October 6, 2008. , 2009, Journal of Lipid Research.

[38]  A. Tamakoshi,et al.  Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women the JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study. , 2008, Journal of the American College of Cardiology.

[39]  M. Tsai,et al.  Immunomodulatory mast cells: negative, as well as positive, regulators of immunity , 2008, Nature Reviews Immunology.

[40]  J. Novotná,et al.  Prevention of Mast Cell Degranulation by Disodium Cromoglycate Attenuates the Development of Hypoxic Pulmonary Hypertension in Rats Exposed to Chronic Hypoxia , 2008, Respiration.

[41]  E. Niki,et al.  Protection against Oxidative Stress-induced Hepatic Injury by Intracellular Type II Platelet-activating Factor Acetylhydrolase by Metabolism of Oxidized Phospholipids in Vivo* , 2008, Journal of Biological Chemistry.

[42]  Melissa A Brown,et al.  The Multitasking Mast Cell: Positive and Negative Roles in the Progression of Autoimmunity , 2007, The Journal of Immunology.

[43]  T. Moon,et al.  Impaired Mast Cell Maturation and Degranulation and Attenuated Allergic Responses in Ndrg1-Deficient Mice1 , 2007, The Journal of Immunology.

[44]  D. Mozaffarian,et al.  Fish intake and risk of incident heart failure. , 2005, Journal of the American College of Cardiology.

[45]  Hon-chi Lee,et al.  Cytochrome p-450 epoxygenase metabolites of docosahexaenoate potently dilate coronary arterioles by activating large-conductance calcium-activated potassium channels. , 2002, The Journal of pharmacology and experimental therapeutics.

[46]  Hiroyuki Arai,et al.  cDNA Cloning and Expression of Intracellular Platelet-activating Factor (PAF) Acetylhydrolase II , 1996, The Journal of Biological Chemistry.

[47]  W. Schofield.  Overview and update. , 1987 .

[48]  W. J. Dyer,et al.  A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.

[49]  K. Tsuchihashi,et al.  Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension. , 2019, American journal of respiratory cell and molecular biology.

[50]  A. Lawrie,et al.  Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension. , 2017, Trends in molecular medicine.

[51]  Clinical Implications. , 2017, Hypertension.

[52]  Pierluigi Gambetti,et al.  Physiology and pathophysiology , 2013 .

[53]  É. Rousseau,et al.  Relaxing effects of 17(18)-EpETE on arterial and airway smooth muscles in human lung. , 2009, American journal of physiology. Lung cellular and molecular physiology.

[54]  I. Fleming.  Vascular cytochrome p450 enzymes: physiology and pathophysiology. , 2008, Trends in cardiovascular medicine.

[55]  M. Rabinovitch.  Molecular pathogenesis of pulmonary arterial hypertension. , 2008, The Journal of clinical investigation.