Oxidative Damage to Sperm DNA: Attack and Defense.

[1]  R. Aitken,et al.  Role of Oxidative Stress in the Etiology of Male Infertility and the Potential Therapeutic Value of Antioxidants , 2019, Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction.

[2]  F. Saez,et al.  Nuclear Integrity but Not Topology of Mouse Sperm Chromosome is Affected by Oxidative DNA Damage , 2018, Genes.

[3]  C. O’Flaherty,et al.  Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa , 2018, Human reproduction.

[4]  R. Aitken.  Not every sperm is sacred; a perspective on male infertility. , 2018, Molecular human reproduction.

[5]  E. Bromfield,et al.  Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress† , 2018, Biology of Reproduction.

[6]  A. Kocer,et al.  A Decade of Exploring the Mammalian Sperm Epigenome: Paternal Epigenetic and Transgenerational Inheritance , 2018, Front. Cell Dev. Biol..

[7]  Jacinta H Martin,et al.  Heat exposure induces oxidative stress and dna damage in the male germ line† , 2018, Biology of Reproduction.

[8]  R. Aitken,et al.  Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay , 2018, Human reproduction.

[9]  Yi Zhang,et al.  TET-mediated active DNA demethylation: mechanism, function and beyond , 2017, Nature Reviews Genetics.

[10]  R. Aitken,et al.  The effects of radiofrequency electromagnetic radiation on sperm function. , 2016, Reproduction.

[11]  R. Aitken.  Oxidative stress and the etiology of male infertility , 2016, Journal of Assisted Reproduction and Genetics.

[12]  R. Aitken,et al.  A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models. , 2016, Human reproduction.

[13]  Oliver J. Rando,et al.  Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals , 2016, Science.

[14]  Xudong Zhang,et al.  Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder , 2016, Science.

[15]  S. Krawetz,et al.  Oxidative DNA damage in mouse sperm chromosomes: Size matters. , 2015, Free radical biology & medicine.

[16]  R. Aitken,et al.  Oxidative stress and human spermatozoa: diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation. , 2015, Molecular human reproduction.

[17]  H. Kuhn,et al.  Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice. , 2015, Antioxidants & redox signaling.

[18]  X. Ni,et al.  ROS-mediated DNA methylation pattern alterations in carcinogenesis. , 2015, Current drug targets.

[19]  J. Zhao,et al.  Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis. , 2014, Fertility and sterility.

[20]  Giovanni Messina,et al.  Short-Term Diet and Moderate Exercise in Young Overweight Men Modulate Cardiocyte and Hepatocarcinoma Survival by Oxidative Stress , 2014, Oxidative medicine and cellular longevity.

[21]  Antonio Ayala,et al.  Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal , 2014, Oxidative medicine and cellular longevity.

[22]  T. Ikemura,et al.  8-oxoguanine causes spontaneous de novo germline mutations in mice , 2014, Scientific Reports.

[23]  K. Ramana,et al.  4-Hydroxynonenal in the pathogenesis and progression of human diseases. , 2013, Current medicinal chemistry.

[24]  R. Aitken,et al.  Oxidative stress and male reproductive health , 2013, Asian journal of andrology.

[25]  F. Saez,et al.  DNA oxidative damage in mammalian spermatozoa: where and why is the male nucleus affected? , 2013, Free radical biology & medicine.

[26]  R. Aitken,et al.  The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line. , 2013, Reproduction.

[27]  Matthew D. Dun,et al.  The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1 , 2013, Journal of Cell Science.

[28]  K. Jones,et al.  Reactive oxygen species and sperm function--in sickness and in health. , 2012, Journal of andrology.

[29]  A. Brunati,et al.  Evaluation of correct endogenous reactive oxygen species content for human sperm capacitation and involvement of the NADPH oxidase system. , 2011, Human reproduction.

[30]  R. Aitken,et al.  The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. , 2011, Human reproduction.

[31]  J. Brouwers,et al.  Mass Spectrometric Detection of Cholesterol Oxidation in Bovine Sperm1 , 2011, Biology of reproduction.

[32]  R. Aitken,et al.  Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa. , 2011, The Biochemical journal.

[33]  R. Aitken,et al.  The Capacitation-Apoptosis Highway: Oxysterols and Mammalian Sperm Function , 2011, Biology of reproduction.

[34]  R. Aitken,et al.  Redox regulation of human sperm function: from the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line. , 2011, Antioxidants & redox signaling.

[35]  S. Krawetz,et al.  The sperm nucleus: chromatin, RNA, and the nuclear matrix. , 2011, Reproduction.

[36]  R. Henkel.  Leukocytes and oxidative stress: dilemma for sperm function and male fertility. , 2011, Asian journal of andrology.

[37]  B. Awda,et al.  Extracellular Signal-Regulated Kinases (ERKs) Pathway and Reactive Oxygen Species Regulate Tyrosine Phosphorylation in Capacitating Boar Spermatozoa1 , 2010, Biology of reproduction.

[38]  B. Dale,et al.  DNA damage and repair in human oocytes and embryos: a review , 2010, Zygote.

[39]  A. Giwercman,et al.  Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study. , 2010, International journal of andrology.

[40]  L. Björndahl,et al.  Human sperm chromatin stabilization: a proposed model including zinc bridges. , 2010, Molecular human reproduction.

[41]  Elizabeth Noonan,et al.  World Health Organization reference values for human semen characteristics. , 2010, Human reproduction update.

[42]  R. Aitken,et al.  DNA Damage in Human Spermatozoa Is Highly Correlated with the Efficiency of Chromatin Remodeling and the Formation of 8-Hydroxy-2′-Deoxyguanosine, a Marker of Oxidative Stress1 , 2009, Biology of reproduction.

[43]  F. Saez,et al.  Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. , 2009, The Journal of clinical investigation.

[44]  P. Cohen-Bacrie,et al.  Correlation between DNA damage and sperm parameters: a prospective study of 1,633 patients. , 2009, Fertility and sterility.

[45]  D. Kang,et al.  Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk. , 2009, Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis.

[46]  R. Aitken,et al.  Biological and clinical significance of DNA damage in the male germ line. , 2009, International journal of andrology.

[47]  C. O’Flaherty,et al.  Positive role of reactive oxygen species in mammalian sperm capacitation: triggering and modulation of phosphorylation events. , 2006, Free radical biology & medicine.

[48]  J. Drevet,et al.  The antioxidant glutathione peroxidase family and spermatozoa: A complex story , 2006, Molecular and Cellular Endocrinology.

[49]  R. Aitken,et al.  A comparative study of oxidative DNA damage in mammalian spermatozoa , 2005, Molecular reproduction and development.

[50]  R. Aitken,et al.  Quantitative analysis of gene-specific DNA damage in human spermatozoa. , 2003, Mutation research.

[51]  H. Clarke,et al.  Remodelling the paternal chromatin at fertilization in mammals. , 2003, Reproduction.

[52]  R. Aitken,et al.  A redox-regulated tyrosine phosphorylation cascade in rat spermatozoa. , 2001, Journal of andrology.

[53]  X. Shi,et al.  Effects of Ni(II) and Cu(II) on DNA interaction with the N-terminal sequence of human protamine P2: enhancement of binding and mediation of oxidative DNA strand scission and base damage. , 1999, Carcinogenesis.

[54]  R. Aitken,et al.  Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. , 1998, Biology of reproduction.

[55]  R. Aitken,et al.  A novel signal transduction cascade in capacitating human spermatozoa characterised by a redox-regulated, cAMP-mediated induction of tyrosine phosphorylation. , 1998, Journal of cell science.

[56]  J. T. Wachsman,et al.  DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis. , 1997, Mutation research.

[57]  R. Aitken.  Molecular mechanisms regulating human sperm function. , 1997, Molecular human reproduction.

[58]  C. Gagnon,et al.  Regulation of protein-tyrosine phosphorylation and human sperm capacitation by reactive oxygen derivatives. , 1997, Free radical biology & medicine.

[59]  A. Lenzi,et al.  Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy. , 1996, Human reproduction update.

[60]  P. Boyle,et al.  Total antioxidant capacity of seminal plasma is different in fertile and infertile men. , 1995, Fertility and sterility.

[61]  R. Aitken,et al.  Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in the control of human sperm function. , 1995, Journal of cell science.

[62]  Roy Jones,et al.  Peroxidative breakdown of phospholipids in human spermatozoa, spermicidal properties of fatty acid peroxides, and protective action of seminal plasma. , 1979, Fertility and sterility.

[63]  T. Mann,et al.  Adverse effects of peroxidized lipid on human spermatozoa , 1978, Proceedings of the Royal Society of London. Series B. Biological Sciences.