论文信息 - SNPs in PI3K-PTEN-mTOR and Brain Metastases in NSCLC—Response

SNPs in PI3K-PTEN-mTOR and Brain Metastases in NSCLC—Response

We thank Giovannetti and colleagues for their thoughtful comments about our recent article ([1][1]) entitled “Associations between Single-Nucleotide Polymorphisms in the PI3K-PTEN-AKT-mTOR Pathway and Increased Risk of Brain Metastasis in Patients with Non–Small Cell Lung Cancer.” In their

Xianglin Yuan | H. Xiong | Qian-xia Li

[1] Z. Liao,et al. Associations between Single-Nucleotide Polymorphisms in the PI3K–PTEN–AKT–mTOR Pathway and Increased Risk of Brain Metastasis in Patients with Non–Small Cell Lung Cancer , 2013, Clinical Cancer Research.

[2] J. Ajani,et al. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[3] P W Lavori,et al. Sample-size calculations for the Cox proportional hazards regression model with nonbinary covariates. , 2000, Controlled clinical trials.

[4] Edward S. Kim,et al. Predictive Biomarkers and Personalized Medicine Genetic Variants in the PI 3 K / PTEN / AKT / mTOR Pathway Predict Head and Neck Cancer Patient Second Primary Tumor / Recurrence Risk and Response to Retinoid Chemoprevention , 2012 .