Caseating Cutaneous Granulomas in a Child with Common Variable Immunodeficiency

Abstract: Cutaneous, noninfectious, granulomatous lesions have been reported occasionally In different types of Immunodeficiencies, Including common variable immunodeficiency (CVID). We present a child with CVID and cutaneous granulomas with a strikingly prominent caseating necrosis. We think that such granulomatous lesions constitute a distinctive manifestation of Immunodeficiency, and may reflect an altered immune response. Corticosteroids have been of benefit to our patient, as well as in similar cases.

[1]  A. Abanmi,et al.  Cutaneous granuloma with ataxia telangiectasia—a case report and review of literature , 1993, Clinical and experimental dermatology.

[2]  S. Douglas,et al.  Outpatient management with oral corticosteroid therapy for obstructive conditions in chronic granulomatous disease. , 1993, The Journal of pediatrics.

[3]  A. Paller,et al.  Cutaneous granulomatous lesions in patients with ataxia-telangiectasia. , 1991, The Journal of pediatrics.

[4]  A. Paller,et al.  Cutaneous granulomas in children with combined immunodeficiency. , 1991, Journal of the American Academy of Dermatology.

[5]  M. G. Fleming,et al.  Caseating cutaneous granulomas in a patient with X-linked infantile hypogammaglobulinemia. , 1991, Journal of the American Academy of Dermatology.

[6]  J. Falloon,et al.  Corticosteroids in treatment of obstructive lesions of chronic granulomatous disease. , 1987, The Journal of pediatrics.

[7]  R. Buckley Immunodeficiency diseases. , 1987, JAMA.

[8]  R. Wasserman,et al.  Ataxia‐telangiectasia Associated with Sarcoidosis , 1986, Pediatric dermatology.

[9]  M. Conley,et al.  Childhood common variable immunodeficiency with autoimmune disease. , 1986, The Journal of pediatrics.

[10]  P. Yap,et al.  Sarcoidosis and primary hypogammaglobulinaemia: a report of two cases and a review of the literature. , 1985, Sarcoidosis.

[11]  G. Burmester,et al.  Pulmonary sarcoidosis associated with acquired humoral and cellular immunodeficiency. , 1985, Clinical immunology and immunopathology.

[12]  C. Lee Acquired hypogammaglobulinaemia and sarcoidosis. , 1984, Postgraduate medical journal.

[13]  F. Rosen,et al.  The primary immunodeficiencies: (second of two parts) , 1984 .

[14]  C. Griscelli,et al.  Common Variable Hypogammaglobulinemia in Children: Clinical and Immunologic Observations in 30 Patients , 1983 .

[15]  P. Fireman,et al.  Hypogammaglobulinemia with sarcoidlike granulomas. , 1983, American journal of diseases of children.

[16]  R. Insel Diagnosis and Treatment of Immunodeficiency Diseases , 1981 .

[17]  D. Vergani,et al.  Sarcoidosis associated with combined immunodeficiency. , 1980, Postgraduate medical journal.

[18]  W. Perks,et al.  Familial combined cellular and humoral immune defect with multisystem granulomata. , 1978, Thorax.

[19]  R. Neiman,et al.  Adult severe combined immunodeficiency and sarcoid‐like granulomas with hypersplenism , 1978, American journal of hematology.

[20]  R. Johnston,et al.  Chronic granulomatous disease: correlation between pathogenesis and clinical findings. , 1971, Pediatrics.

[21]  D. James,et al.  Hypogammaglobulinemia, depression of delayed-type hypersensitivity, and granuloma formation. , 1971, The American review of respiratory disease.

[22]  R. Good,et al.  Dermatologic manifestations of fatal granulomatous disease of childhood. , 1971, Archives of dermatology.

[23]  M. Skinner,et al.  Primary acquired agammaglobulinemia, with granulomas of the skin and internal organs. , 1970, Archives of dermatology.

[24]  D. Bronsky,et al.  SARCOIDOSIS WITH HYPOGAMMAGLOBULINEMIA , 1965, The American journal of the medical sciences.

[25]  Benjamin Castleman,et al.  Case 6-1963 , 1963 .