Evidence that a family of miniature inverted-repeat transposable elements (MITEs) from the Arabidopsis thaliana genome has arisen from a pogo-like DNA transposon.

Sequence similarities exist between terminal inverted repeats (TIRs) of some miniature inverted-repeat transposable element (MITE) families isolated from a wide range of organisms, including plants, insects, and humans, and TIRs of DNA transposons from the pogo family. We present here evidence that one of these MITE families, previously described for Arabidopsis thaliana, is derived from a larger element encoding a putative transposase. We have named this novel class II transposon Lemi1. We show that its putative product is related to transposases of the Tc1/mariner superfamily, being closer to the pogo family. A similar truncated element was found in a tomato DNA sequence, indicating an ancient origin and/or horizontal transfer for this family of elements. These results are reminiscent of those recently reported for the human genome, where other members of the pogo family, named Tiggers, are believed to be responsible for the generation of abundant MITE-like elements in an early primate ancestor. These results further suggest that some MITE families, which are highly reiterated in plant, insect, and human genomes, could have arisen from a similar mechanism, implicating pogo-like elements.

[1]  C Braquart,et al.  DEC: a new miniature inverted‐repeat transposable element from the genome of the beetle Tenebrio molitor , 1999, Insect molecular biology.

[2]  R. Plasterk,et al.  Resident aliens: the Tc1/mariner superfamily of transposable elements. , 1999, Trends in genetics : TIG.

[3]  W. Belknap,et al.  Characterization of Repetitive DNA Elements in Arabidopsis , 1999, Journal of Molecular Evolution.

[4]  Perry B. Hackett,et al.  Short Inverted-Repeat Transposable Elements in Teleost Fish and Implications for a Mechanism of Their Amplification , 1999, Journal of Molecular Evolution.

[5]  H. Wang,et al.  Pogo transposase contains a putative helix-turn-helix DNA binding domain that recognises a 12 bp sequence within the terminal inverted repeats. , 1999, Nucleic acids research.

[6]  A. Monfort,et al.  Presence of miniature inverted-repeat transposable elements (MITEs) in the genome of Arabidopsis thaliana: characterisation of the Emigrant family of elements. , 1998, The Plant journal : for cell and molecular biology.

[7]  D. Lane,et al.  PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain. , 1998, Nucleic acids research.

[8]  Z. Kelman,et al.  Protein-PCNA interactions: a DNA-scanning mechanism? , 1998, Trends in biochemical sciences.

[9]  K. Lark,et al.  Characterization of Soymar1, a mariner element in soybean. , 1998, Genetics.

[10]  J. Hurwitz,et al.  Purification and characterization of a CENP-B homologue protein that binds to the centromeric K-type repeat DNA of Schizosaccharomyces pombe. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[11]  M. G. Kidwell,et al.  Transposable elements as sources of variation in animals and plants. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Z. Tu,et al.  Three novel families of miniature inverted-repeat transposable elements are associated with genes of the yellow fever mosquito, Aedes aegypti. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Anders Gorm Pedersen,et al.  Neural Network Prediction of Translation Initiation Sites in Eukaryotes: Perspectives for EST and Genome Analysis , 1997, ISMB.

[14]  S. Henikoff,et al.  A helix-turn-helix DNA-binding motif predicted for transposases of DNA transposons , 1997, Molecular and General Genetics MGG.

[15]  D. Hartl,et al.  Modern thoughts on an ancyent marinere: function, evolution, regulation. , 1997, Annual review of genetics.

[16]  Claude Bazin,et al.  Dynamics and evolution of trans-posable elements , 1996 .

[17]  A. Smit,et al.  The origin of interspersed repeats in the human genome. , 1996, Current opinion in genetics & development.

[18]  R. Britten,et al.  DNA sequence insertion and evolutionary variation in gene regulation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Peter G. Korning,et al.  Splice Site Prediction in Arabidopsis Thaliana Pre-mRNA by Combining Local and Global Sequence Information , 1996 .

[20]  S. Wessler,et al.  A computer-based systematic survey reveals the predominance of small inverted-repeat elements in wild-type rice genes. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[21]  A. Smit,et al.  Tiggers and DNA transposon fossils in the human genome. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[22]  K. Murphy,et al.  Optimal Alignments in Linear Space Using Automaton-derived Cost Functions (extended Abstract) , 1996 .

[23]  S. Wessler,et al.  LTR-retrotransposons and MITEs: important players in the evolution of plant genomes. , 1995, Current opinion in genetics & development.

[24]  G. Morgan,et al.  A novel group of families of short interspersed repetitive elements (SINEs) in Xenopus: evidence of a specific target site for DNA-mediated transposition of inverted-repeat SINEs. , 1995, Journal of molecular biology.

[25]  J. McDonald,et al.  Transposable elements: possible catalysts of organismic evolution. , 1995, Trends in ecology & evolution.

[26]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[27]  Ronald H. A. Plasterk,et al.  The mechanism of transposition of Tc3 in C. elegans , 1994, Cell.

[28]  K. Sugimoto,et al.  Functional domain structure of human centromere protein B. Implication of the internal and C-terminal self-association domains in centromeric heterochromatin condensation. , 1994, The Journal of biological chemistry.

[29]  P. Anderson,et al.  The Tc5 family of transposable elements in Caenorhabditis elegans. , 1994, Genetics.

[30]  S. Wessler,et al.  Stowaway: a new family of inverted repeat elements associated with the genes of both monocotyledonous and dicotyledonous plants. , 1994, The Plant cell.

[31]  T. Doak,et al.  A proposed superfamily of transposase genes: transposon-like elements in ciliated protozoa and a common "D35E" motif. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[32]  S. Wessler,et al.  Tourist: a large family of small inverted repeat elements frequently associated with maize genes. , 1992, The Plant cell.

[33]  V. Ruvolo,et al.  The Tc2 transposon of Caenorhabditis elegans has the structure of a self-regulated element. , 1992, DNA and cell biology.

[34]  N. Fedoroff.  Maize Transposable Elements , 2015 .

[35]  H. Horvitz,et al.  Tc4, a Caenorhabditis elegans transposable element with an unusual fold-back structure. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[36]  E. Myers,et al.  Basic local alignment search tool. , 1990, Journal of molecular biology.

[37]  I. Dodd,et al.  Improved detection of helix-turn-helix DNA-binding motifs in protein sequences. , 1990, Nucleic acids research.

[38]  D. Finnegan,et al.  Eukaryotic transposable elements and genome evolution. , 1989, Trends in genetics : TIG.

[39]  H. Saedler,et al.  Maize transposable elements. , 1989, Annual review of genetics.

[40]  S. Beckendorf,et al.  The structure of hobo transposable elements and their insertion sites , 1986, The EMBO journal.

[41]  G. Rubin,et al.  Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome , 1983, Cell.