Cytomegalovirus Anterior Uveitis Following Topical Cyclosporine A

ABSTRACT Cytomegalovirus (CMV) anterior uveitis and endotheliitis occurs among immunocompetent individuals and may manifest as Posner–Schlossman syndrome or Fuchs uveitis syndrome. The condition may first present following ophthalmic surgery, the use of a fluocinolone-sustained steroid drug delivery implant, or the use of topical prostaglandin analogues for the treatment of glaucoma. We report the first case of a non-human immunodeficiency virus-infected individual who presented with CMV anterior uveitis after the use of topical cyclosporine A 0.05% ophthalmic emulsion for the treatment of symptomatic dry eyes.

[1]  Ozlem Eşki Yücel,et al.  Efficacy and safety of topical cyclosporine A 0.05% in vernal keratoconjunctivitis. , 2016, Singapore medical journal.

[2]  J. Mehta,et al.  Histological features of Cytomegalovirus-related corneal graft infections, its associated features and clinical significance , 2015, British Journal of Ophthalmology.

[3]  Roni M. Shtein,et al.  Topical cyclosporine A 0.05% for recurrent anterior uveitis , 2015, British Journal of Ophthalmology.

[4]  G. Murthy,et al.  Cytomegalovirus anterior uveitis in immunocompetent individuals following topical prostaglandin analogues , 2013, Journal of Ophthalmic Inflammation and Infection.

[5]  P. Murray,et al.  Post-phacoemulsification cytomegalovirus corneal endotheliitis diagnosis and management , 2012, JRSM short reports.

[6]  V. Jhanji,et al.  Corneal endotheliitis triggered by cataract surgery in a Chinese patient with cytomegalovirus anterior uveitis , 2011, Clinical & experimental ophthalmology.

[7]  H. Yu,et al.  Cytomegalovirus Endotheliitis after Fluocinolone Acetonide (Retisert) Implant in a Patient with Behçet Uveitis , 2011, Ocular immunology and inflammation.

[8]  Sarah E. Jackson,et al.  Human cytomegalovirus immunity and immune evasion. , 2011, Virus research.

[9]  L. Módis,et al.  Dry eye diagnosis and management , 2011 .

[10]  C. Shiboski,et al.  A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International Registry. , 2010, American journal of ophthalmology.

[11]  S. Chee,et al.  Cytomegalovirus endotheliitis following fluocinolone acetonide (Retisert) implant , 2010, Eye.

[12]  J. Sheppard,et al.  Modalities to decrease stromal herpes simplex keratitis reactivation rates. , 2009, Archives of ophthalmology.

[13]  S. Chee,et al.  Presumed fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and negative eyes. , 2008, American journal of ophthalmology.

[14]  S. Chee,et al.  Clinical features of cytomegalovirus anterior uveitis in immunocompetent patients. , 2008, American journal of ophthalmology.

[15]  P. Tomasec,et al.  Modulation of natural killer cells by human cytomegalovirus. , 2008, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[16]  M. Irkec,et al.  Topical Cyclosporine A in the Treatment of Superior Limbic Keratoconjunctivitis: A Long-Term Follow-Up , 2008, Cornea.

[17]  S. Chee,et al.  Corneal endotheliitis associated with evidence of cytomegalovirus infection. , 2007, Ophthalmology.

[18]  W. Flanders,et al.  Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[19]  R. Rao,et al.  Efficacy of Topical Cyclosporine 0.05% in the Treatment of Dry Eye Associated With Graft Versus Host Disease , 2006, Cornea.

[20]  S. N. Rao Treatment of herpes simplex virus stromal keratitis unresponsive to topical prednisolone 1% with topical cyclosporine 0.05%. , 2006, American journal of ophthalmology.

[21]  O. Abitbol,et al.  Topical cyclosporine A in severe steroid-dependent childhood phlyctenular keratoconjunctivitis. , 2006, American journal of ophthalmology.

[22]  Douglas A Jabs,et al.  Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. , 2005, American journal of ophthalmology.

[23]  E. Donnenfeld,et al.  Dry eye diagnosis and management in 2004 , 2004, Current opinion in ophthalmology.

[24]  S. Ti,et al.  Pharmacokinetic and toxicity study of an intraocular cyclosporine DDS in the anterior segment of rabbit eyes. , 2003, Investigative ophthalmology & visual science.

[25]  D. Tan,et al.  Distribution of cyclosporin A in the cornea after topical or oral administration. , 2002, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[26]  D. Sedmak,et al.  Cytomegalovirus and transcriptional down-regulation of major histocompatibility complex class II expression. , 2001, Seminars in immunology.

[27]  B. Reis,et al.  Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease1 , 2000 .

[28]  S. Ding,et al.  Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs. , 1999, Current eye research.

[29]  J. Gottsch,et al.  Persisting epithelial herpes simplex keratitis while on cyclosporin-A ointment. , 1995, Australian and New Zealand journal of ophthalmology.

[30]  L. Sun,et al.  Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains , 1995, Journal of virology.

[31]  Xiu-ying Jin,et al.  Local therapy of corneal allograft rejection with cyclosporine. , 1995, American journal of ophthalmology.

[32]  R. Nussenblatt,et al.  Clinical Use of Cyclosporine in Ocular Disease , 1993, International ophthalmology clinics.