Increased sensitivity of melanocytes to oxidative stress and abnormal expression of tyrosinase‐related protein in vitiligo

Background  Vitiligo is a depigmenting disease of the skin, which may derive from programmed melanocyte death or destruction due to inherent sensitivity to oxidative stress arising from either toxic intermediates of melanin, a melanocyte‐specific protein, or other sources. Tyrosinase‐related protein (TRP) ‐1 has been shown to be involved not only in melanin biosynthesis but also in the prevention of premature melanocyte death in animals.

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