Noninvasive Imaging of Human Oral Mucosa in Vivo by Confocal Reflectance Microscopy

Objectives/Hypothesis: To study the microscopic anatomy of normal oral tissues in vivo using confocal reflectance microscopy (CRM). This novel and noninvasive imaging modality can define and characterize healthy oral mucosa and thus this work serves as the foundation for studying oral diseases in vivo.

[1]  P. Corcuff,et al.  In vivo vision of the human skin with the tandem scanning microscope. , 1993, Dermatology.

[2]  J. Mcdonald,et al.  Tumors of the head and neck. , 1950, The South Dakota journal of medicine and pharmacy.

[3]  A. Jalkh,et al.  Characterization of functional changes in macular holes and cysts. , 1991, Ophthalmology.

[4]  R N Weinreb,et al.  Confocal scanning infrared laser ophthalmoscopy for indocyanine green angiography. , 1995, American journal of ophthalmology.

[5]  M Rajadhyaksha,et al.  Allergic contact dermatitis: correlation of in vivo confocal imaging to routine histology. , 1999, Journal of the American Academy of Dermatology.

[6]  I Itzkan,et al.  Autofluorescence characteristics of oral mucosa , 1997, Head & neck.

[7]  Leonardo Masotti,et al.  Basic Principles and Advanced Technological Aspects of Ultrasound Imaging , 1987 .

[8]  S. Srivannaboon,et al.  Normal Human Corneal Cell Populations Evaluated by In Vivo Scanning Slit Confocal Microscopy , 1998, Cornea.

[9]  M. Rajadhyaksha,et al.  Confocal imaging of sebaceous gland hyperplasia in vivo to assess efficacy and mechanism of pulsed dye laser treatment , 1999, Lasers in surgery and medicine.

[10]  H Stepp,et al.  Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced protoporphyrin IX for the detection of neoplastic lesions in the oral cavity. , 1996, American journal of surgery.

[11]  R. Webb,et al.  Video-rate confocal scanning laser microscope for imaging human tissues in vivo. , 1999, Applied optics.

[12]  S. A. Boppart,et al.  Optical imaging technology in minimally invasive surgery , 1999, Surgical Endoscopy.

[13]  R. Webb Confocal optical microscopy , 1996 .

[14]  B R Masters,et al.  Three‐dimensional microscopic biopsy of in vivo human skin: a new technique based on a flexible confocal microscope , 1997, Journal of microscopy.

[15]  E. Lane,et al.  The utility of cytokeratin profiles for detecting oral cancer using exfoliative cytology. , 1996, The British journal of oral & maxillofacial surgery.

[16]  R. Allemand Basic Technological Aspects and Optimization Problems in X-Ray Computed Tomography (C.T.) , 1987 .

[17]  M. Rajadhyaksha,et al.  Confocal reflectance imaging of folliculitis in vivo: correlation with routine histology , 1999, Journal of cutaneous pathology.

[18]  S. Jacques,et al.  Optical reflectance and transmittance of tissues: principles and applications , 1990 .

[19]  H. D. Cavanagh,et al.  Tandem scanning confocal microscopy (TSCM) of normal and ischemic living kidneys. , 1991, The American journal of anatomy.

[20]  S. Kaufman,et al.  Confocal microscopy: a new tool for the study of the nail unit. , 1995, Journal of the American Academy of Dermatology.

[21]  C. Cullander Light microscopy of living tissue: the state and future of the art. , 1998, The journal of investigative dermatology. Symposium proceedings.

[22]  R. Webb,et al.  Confocal scanning laser ophthalmoscope. , 1987, Applied optics.

[23]  R. Webb,et al.  In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. , 1995, The Journal of investigative dermatology.

[24]  M. Sayed TECHNICAL MAGNETIC RESONANCE IMAGING , 1997 .

[25]  D W Rattner,et al.  Optical imaging technology in minimally invasive surgery. Current status and future directions. , 1999, Surgical endoscopy.

[26]  Sheila J. Jones,et al.  Vital confocal microscopy in bone. , 2006, Scanning.

[27]  N. Johnson,et al.  Sensitivity and specificity of OraScan (R) toluidine blue mouthrinse in the detection of oral cancer and precancer. , 1996, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[28]  M Rajadhyaksha,et al.  Non-invasive (real-time) imaging of histologic margin of a proliferative skin lesion in vivo. , 1998, The Journal of investigative dermatology.

[29]  Andres J Klein-Szanto,et al.  Architecture and density of the connective tissue papillae of the human oral mucosa. , 1977, Journal of anatomy.

[30]  R A Schuchard,et al.  Landmark-driven fundus perimetry using the scanning laser ophthalmoscope. , 1995, Investigative ophthalmology & visual science.

[31]  A. Boyde,et al.  In vivo imaging of human teeth and skin using real-time confocal microscopy , 1991 .

[32]  B. Young,et al.  Wheater's Functional Histology: A Text and Colour Atlas , 1993 .

[33]  W M Petroll,et al.  In vivo confocal microscopy in clinical dental research: an initial appraisal. , 1992, Journal of dentistry.

[34]  W M Petroll,et al.  Clinical and diagnostic use of in vivo confocal microscopy in patients with corneal disease. , 1993, Ophthalmology.

[35]  J. Fujimoto,et al.  In vivo endoscopic optical biopsy with optical coherence tomography. , 1997, Science.

[36]  H. Schroeder Differentiation of Human Oral Stratified Epithelia , 1981 .

[37]  M Rajadhyaksha,et al.  Near-infrared confocal laser scanning microscopy of bladder tissue in vivo. , 1999, Urology.