Can currently available non-animal methods detect pre and pro-haptens relevant for skin sensitization?

[1]  A Worth,et al.  Consensus of classification trees for skin sensitisation hazard prediction. , 2016, Toxicology in vitro : an international journal published in association with BIBRA.

[2]  I. Namer,et al.  In Situ Metabolism of Cinnamyl Alcohol in Reconstructed Human Epidermis: New Insights into the Activation of This Fragrance Skin Sensitizer. , 2016, Chemical research in toxicology.

[3]  R. Landsiedel,et al.  Assessment of Pre- and Pro-haptens Using Nonanimal Test Methods for Skin Sensitization. , 2016, Chemical research in toxicology.

[4]  David Allen,et al.  Adverse outcome pathways: From research to regulation scientific workshop report. , 2016, Regulatory toxicology and pharmacology : RTP.

[5]  Yu-Mei Tan,et al.  Adverse Outcome Pathways—Organizing Toxicological Information to Improve Decision Making , 2016, The Journal of Pharmacology and Experimental Therapeutics.

[6]  Asturiol Bofill David,et al.  Ability of non-animal methods for skin sensitisation to detect pre- and pro-haptens: Report and recommendations of an EURL ECVAM expert meeting , 2016 .

[7]  Andrew Worth,et al.  Alternatives for skin sensitisation: Hazard identification and potency categorisation: Report from an EPAA/CEFIC LRI/Cosmetics Europe cross sector workshop, ECHA Helsinki, April 23rd and 24th 2015. , 2015, Regulatory toxicology and pharmacology : RTP.

[8]  Division on Earth.  Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense , 2015 .

[9]  Casati Silvia,et al.  EURL ECVAM Recommendation on the human Cell Line Activation Test (h-CLAT) for skin sensitisation testing , 2015 .

[10]  N. Hewitt,et al.  Dermal Xenobiotic Metabolism: A Comparison between Native Human Skin, Four in vitro Skin Test Systems and a Liver System , 2014, Skin Pharmacology and Physiology.

[11]  G Patlewicz,et al.  TIMES-SS – Recent refinements resulting from an industrial skin sensitisation consortium$ , 2014, SAR and QSAR in environmental research.

[12]  João Barroso,et al.  Categorization of Chemicals According to Their Relative Human Skin Sensitizing Potency , 2014, Dermatitis : contact, atopic, occupational, drug.

[13]  Zuang Valerie,et al.  EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2013-April 2014) , 2014 .

[14]  Casati Silvia,et al.  EURL ECVAM Recommendation on the KeratinoSensTM assay for skin sensitisation testing , 2014 .

[15]  W. Uter,et al.  Activation of non‐sensitizing or low‐sensitizing fragrance substances into potent sensitizers – prehaptens and prohaptens , 2013, Contact dermatitis.

[16]  Casati Silvia,et al.  EURL ECVAM Recommendation on the Direct Peptide Reactivity Assay (DPRA) for Skin Sensitisation Testing , 2013 .

[17]  Detlef Keller,et al.  Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: skin sensitisation. , 2012, Regulatory toxicology and pharmacology : RTP.

[18]  U. Nilsson,et al.  α-Terpinene, an antioxidant in tea tree oil, autoxidizes rapidly to skin allergens on air exposure. , 2012, Chemical research in toxicology.

[19]  Valérie Zuang,et al.  Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010 , 2011, Archives of Toxicology.

[20]  Andreas Natsch,et al.  Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. , 2010, Toxicology and applied pharmacology.

[21]  Aynur Aptula,et al.  Local Lymph Node Data for the Evaluation of Skin Sensitization Alternatives: A Second Compilation , 2010, Dermatitis : contact, atopic, occupational, drug.

[22]  H. Merk,et al.  Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens. , 2008, Toxicology and applied pharmacology.

[23]  David W Roberts,et al.  Determinants of skin sensitisation potential , 2008, Journal of applied toxicology : JAT.

[24]  Andreas Natsch,et al.  Skin Sensitizers Induce Antioxidant Response Element Dependent Genes: Application to the In Vitro Testing of the Sensitization Potential of Chemicals , 2008 .

[25]  Grace Patlewicz,et al.  A comparison of reactivity schemes for the prediction skin sensitization potential. , 2008, Chemical research in toxicology.

[26]  Kristina Luthman,et al.  Allergic contact dermatitis--formation, structural requirements, and reactivity of skin sensitizers. , 2008, Chemical research in toxicology.

[27]  Petra S Kern,et al.  TIMES-SS--a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity. , 2007, Regulatory toxicology and pharmacology : RTP.

[28]  Petra S Kern,et al.  Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization. , 2007, Chemical research in toxicology.

[29]  G Frank Gerberick,et al.  Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[30]  G. Nyman,et al.  Fragrance compound geraniol forms contact allergens on air exposure. Identification and quantification of oxidation products and effect on skin sensitization. , 2007, Chemical research in toxicology.

[31]  Grace Patlewicz,et al.  Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay. , 2007, Chemical research in toxicology.

[32]  H. Sakaguchi,et al.  Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol. , 2006, Toxicology in vitro : an international journal published in association with BIBRA.

[33]  K. Luthman,et al.  Conjugated dienes as prohaptens in contact allergy: in vivo and in vitro studies of structure-activity relationships, sensitizing capacity, and metabolic activation. , 2006, Chemical research in toxicology.

[34]  J. Lepoittevin.  Metabolism versus chemical transformation or pro‐ versus prehaptens? , 2006, Contact dermatitis.

[35]  Ian Kimber,et al.  Compilation of Historical Local Lymph Node Data for Evaluation of Skin Sensitization Alternative Methods , 2005, Dermatitis : contact, atopic, occupational, drug.

[36]  Grace Patlewicz,et al.  Skin sensitization: reaction mechanistic applicability domains for structure-activity relationships. , 2005, Chemical research in toxicology.

[37]  Petra S. Kern,et al.  Skin Sensitization: Modeling Based on Skin Metabolism Simulation and Formation of Protein Conjugates , 2005, International journal of toxicology.

[38]  G Frank Gerberick,et al.  Development of a peptide reactivity assay for screening contact allergens. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[39]  J. Foussereau,et al.  Occupational dermatitis to Ampholyt G in hospital personnel , 1983, Contact dermatitis.