Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis.

[1]  O. Nielsen,et al.  Tumor necrosis factor inhibitors for inflammatory bowel disease. , 2013, The New England journal of medicine.

[2]  Burkhard Becher,et al.  IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells , 2012, The Journal of experimental medicine.

[3]  G. Dalmasso,et al.  Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in ApcMin/+ mice , 2012, Laboratory Investigation.

[4]  M. Perše,et al.  Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks , 2012, Journal of biomedicine & biotechnology.

[5]  G. Núñez,et al.  Sensing and reacting to microbes through the inflammasomes , 2012, Nature Immunology.

[6]  J. Luk,et al.  Tripterygium wilfordii bioactive compounds as anticancer and anti‐inflammatory agents , 2012, Clinical and experimental pharmacology & physiology.

[7]  J. Becker,et al.  LITAF Mediation of Increased TNF-α Secretion from Inflamed Colonic Lamina Propria Macrophages , 2011, PloS one.

[8]  R. Xavier,et al.  Genetics and pathogenesis of inflammatory bowel disease , 2011, Nature.

[9]  M. D’Amato,et al.  CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice. , 2011, The Journal of clinical investigation.

[10]  D. Han,et al.  Role of IL-17A in the development of colitis-associated cancer. , 2011, Carcinogenesis.

[11]  G. Sethi,et al.  Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. , 2011, Cancer letters.

[12]  Haitao Wen,et al.  The inflammasome NLRs in immunity, inflammation, and associated diseases. , 2011, Annual review of immunology.

[13]  Fiona Powrie,et al.  An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer , 2010, The Journal of experimental medicine.

[14]  H. Herfarth,et al.  The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer , 2010, The Journal of experimental medicine.

[15]  T. Brunner,et al.  TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis , 2010, The Journal of experimental medicine.

[16]  J. Tschopp,et al.  Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome , 2010, Gut.

[17]  A. Salminen,et al.  Celastrol: Molecular targets of Thunder God Vine. , 2010, Biochemical and biophysical research communications.

[18]  M. Kastan,et al.  The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. , 2010, Immunity.

[19]  N. Beauchemin,et al.  Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. , 2010, Immunity.

[20]  Mingyao Liu,et al.  Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. , 2010, Cancer research.

[21]  S. Targan,et al.  Future biologic targets for IBD: potentials and pitfalls , 2010, Nature Reviews Gastroenterology &Hepatology.

[22]  A. Stadnyk,et al.  Role of TNF receptors, TNFR1 and TNFR2, in dextran sodium sulfate‐induced colitis , 2009, Inflammatory bowel diseases.

[23]  E. Alnemri,et al.  Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1 , 2009, The Journal of Immunology.

[24]  Qingshan Li,et al.  AP-1 Activated by Toll-like Receptors Regulates Expression of IL-23 p19* , 2009, The Journal of Biological Chemistry.

[25]  N. Sakamoto,et al.  Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[26]  T. Okanoue,et al.  Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. , 2008, Biochemical and biophysical research communications.

[27]  K. Takeuchi,et al.  Roles of nitric oxide (NO) and NO synthases in healing of dextran sulfate sodium-induced rat colitis. , 2008, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[28]  David C. Ford,et al.  Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. , 2008, American journal of physiology. Gastrointestinal and liver physiology.

[29]  Y. Naito,et al.  Neutrophil-Dependent Oxidative Stress in Ulcerative Colitis , 2007, Journal of clinical biochemistry and nutrition.

[30]  Y. Iwakura,et al.  The IL-23/IL-17 axis in inflammation. , 2006, The Journal of clinical investigation.

[31]  J. Kolls,et al.  Critical role of IL‐17 receptor signaling in acute TNBS‐induced colitis , 2006, Inflammatory bowel diseases.

[32]  D. Merlin,et al.  Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation , 2005, Laboratory Investigation.

[33]  E. Pålsson-McDermott,et al.  Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4 , 2004, Immunology.

[34]  Y. Naito,et al.  Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor‐alpha deficient mice , 2003, Journal of gastroenterology and hepatology.

[35]  D. Mosser,et al.  The many faces of macrophage activation , 2003, Journal of leukocyte biology.

[36]  A. Husband,et al.  The inflammatory infiltrate in the acute stage of the dextran sulphate sodium induced colitis: B cell response differs depending on the percentage of DSS used to induce it , 2001, BMC clinical pathology.

[37]  D. Wink,et al.  A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. , 2001, Nitric oxide : biology and chemistry.

[38]  I. Erdelmeier,et al.  Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation. , 1998, Chemical research in toxicology.

[39]  H. Cooper,et al.  Clinicopathologic study of dextran sulfate sodium experimental murine colitis. , 1993, Laboratory investigation; a journal of technical methods and pathology.

[40]  A. Bylund-Fellenius,et al.  Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity. , 1990, Journal of pharmacological methods.

[41]  T. Ohkusa,et al.  A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice , 1990 .

[42]  R. E. Beyer,et al.  A rapid biuret assay for protein of whole fatty tissues. , 1983, Analytical biochemistry.

[43]  B. Mannervik,et al.  Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. , 1979, Biochimica et biophysica acta.

[44]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[45]  W B Jakoby,et al.  Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. , 1974, The Journal of biological chemistry.

[46]  S. Marklund,et al.  Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. , 1974, European journal of biochemistry.

[47]  S. Gordon Alternative activation of macrophages , 2003, Nature Reviews Immunology.