Setting the pace: mechanisms tying Caulobacter cell-cycle progression to macroscopic cellular events.

The bacterium Caulobacter crescentus divides asymmetrically, producing daughter cells with differing polar structures, different cell fates and asymmetric regulation of the initiation of chromosome replication. Complex intracellular signaling is required to keep the organelle developmental processes at the cell poles synchronized with other cell cycle events. Two recently characterized switch mechanisms controlling cell cycle progress are triggered by relatively large-scale developmental events in the cell: the progress of the DNA replication fork and the physical compartmentalization of the cell that occurs well before division. These mechanisms invoke rapid, precisely timed and even spatially differentiated regulatory responses at important points in the cell cycle.

[1]  U. Jenal,et al.  The Caulobacter cell cycle: timing, spatial organization and checkpoints. , 2002, Current opinion in microbiology.

[2]  A. Arkin,et al.  It's a noisy business! Genetic regulation at the nanomolar scale. , 1999, Trends in genetics : TIG.

[3]  Y. Brun,et al.  CtrA mediates a DNA replication checkpoint that prevents cell division in Caulobacter crescentus , 2000, The EMBO journal.

[4]  Lucy Shapiro,et al.  A signal transduction protein cues proteolytic events critical to Caulobacter cell cycle progression , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Lucy Shapiro,et al.  DNA methylation affects the cell cycle transcription of the CtrA global regulator in Caulobacter , 2002, The EMBO journal.

[6]  Lucy Shapiro,et al.  Cell Cycle–Dependent Polar Localization of an Essential Bacterial Histidine Kinase that Controls DNA Replication and Cell Division , 1999, Cell.

[7]  L. Shapiro,et al.  Negative control of bacterial DNA replication by a cell cycle regulatory protein that binds at the chromosome origin. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[8]  A. Arkin,et al.  Stochastic mechanisms in gene expression. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Y. Brun,et al.  Cell cycle timing and developmental checkpoints in Caulobacter crescentus. , 2003, Current opinion in microbiology.

[10]  Kathleen R Ryan,et al.  Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[11]  H. Lam,et al.  The asymmetric spatial distribution of bacterial signal transduction proteins coordinates cell cycle events. , 2003, Developmental cell.

[12]  R. B. Jensen,et al.  Dynamic localization of proteins and DNA during a bacterial cell cycle , 2002, Nature Reviews Molecular Cell Biology.

[13]  H. McAdams,et al.  Global analysis of the genetic network controlling a bacterial cell cycle. , 2000, Science.

[14]  Lucy Shapiro,et al.  Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Patrick Goymer,et al.  Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus , 2003, Molecular microbiology.

[16]  U. Jenal,et al.  An essential protease involved in bacterial cell‐cycle control , 1998, The EMBO journal.

[17]  B. Giese,et al.  Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. , 2004, Genes & development.

[18]  J. Gober,et al.  Cell cycle control of cell morphogenesis in Caulobacter. , 2001, Current opinion in microbiology.

[19]  Stuart J Cordwell,et al.  Functions of the CckA histidine kinase in Caulobacter cell cycle control , 2003, Molecular microbiology.

[20]  C. Jacobs-Wagner.  Regulatory proteins with a sense of direction: cell cycle signalling network in Caulobacter , 2003, Molecular microbiology.

[21]  Lucy Shapiro,et al.  Cell Cycle Control by an Essential Bacterial Two-Component Signal Transduction Protein , 1996, Cell.

[22]  N. Ohta,et al.  An essential, multicomponent signal transduction pathway required for cell cycle regulation in Caulobacter. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Jeffrey M. Skerker,et al.  Identification and cell cycle control of a novel pilus system in Caulobacter crescentus , 2000, The EMBO journal.

[24]  L. Shapiro,et al.  Feedback control of a master bacterial cell-cycle regulator. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[25]  C. Jacobs-Wagner,et al.  Spatial and temporal control of differentiation and cell cycle progression in Caulobacter crescentus. , 2003, Annual review of microbiology.

[26]  Y. Brun,et al.  Cell cycle-dependent transcriptional and proteolytic regulation of FtsZ in Caulobacter. , 1998, Genes & development.

[27]  Lucy Shapiro,et al.  A Bacterial Cell-Cycle Regulatory Network Operating in Time and Space , 2003, Science.

[28]  Kathleen R Ryan,et al.  Temporal and spatial regulation in prokaryotic cell cycle progression and development. , 2003, Annual review of biochemistry.