αvβ3 and αvβ5 integrin antagonists inhibit angiogenesis in vitro

[1]  Thilo Stehle,et al.  Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand , 2002, Science.

[2]  D. Stupack,et al.  Integrin-mediated death: An explanation of the integrin-knockout phenotype? , 2002, Nature Medicine.

[3]  D. Taverna,et al.  Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. , 2002, Nature medicine.

[4]  David A. Cheresh,et al.  Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins , 2001, The Journal of cell biology.

[5]  C. Jackson,et al.  Human endothelial gelatinases and angiogenesis. , 2001, The international journal of biochemistry & cell biology.

[6]  Erwin G. Van Meir,et al.  Response of bovine endothelial cells to FGF‐2 and VEGF is dependent on their site of origin: Relevance to the regulation of angiogenesis , 2001, Journal of cellular biochemistry.

[7]  S. Maxwell,et al.  Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. , 2001, Journal of cell science.

[8]  P. Carmeliet,et al.  Molecular mechanisms of blood vessel growth. , 2001, Cardiovascular research.

[9]  Richard Mayne,et al.  Multiple Binding Sites in Collagen Type I for the Integrins α1β1 and α2β1 * , 2000, The Journal of Biological Chemistry.

[10]  T. Byzova,et al.  A mechanism for modulation of cellular responses to VEGF: activation of the integrins. , 2000, Molecular cell.

[11]  G. Davis,et al.  RGD-Dependent Vacuolation and Lumen Formation Observed during Endothelial Cell Morphogenesis in Three-Dimensional Fibrin Matrices Involves the αvβ3 and α5β1 Integrins , 2000 .

[12]  Robert V Farese,et al.  Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice , 2000, Molecular and Cellular Biology.

[13]  R. Rich,et al.  Multiple binding sites in collagen type I for the integrins alpha1beta1 and alpha2beta1. , 2000, The Journal of biological chemistry.

[14]  G. Davis,et al.  RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the alpha(v)beta(3) and alpha(5)beta(1) integrins. , 2000, The American journal of pathology.

[15]  Horst Kessler,et al.  N-methylated cyclic RGD peptides as highly active and selective αvβ3 integrin antagonists , 1999 .

[16]  F. Mitjans,et al.  Integrin αVβ3 Promotes M21 Melanoma Growth in Human Skin by Regulating Tumor Cell Survival , 1999 .

[17]  J. Mulliken,et al.  The role of matrix metalloproteinase activity in the maturation of human capillary endothelial cells in vitro. , 1999, Journal of cell science.

[18]  M. Pepper,et al.  Endothelial cell integrin alpha5beta1 expression is modulated by cytokines and during migration in vitro. , 1999, Journal of cell science.

[19]  R. Hynes,et al.  Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. , 1999, The Journal of clinical investigation.

[20]  S. Goodman,et al.  Definition of an unexpected ligand recognition motif for alphav beta6 integrin. , 1999, The Journal of biological chemistry.

[21]  E Ruoslahti,et al.  Integrin signaling. , 1999, Science.

[22]  S. Goodman,et al.  N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. , 1999, Journal of medicinal chemistry.

[23]  F. Mitjans,et al.  Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival. , 1999, Cancer research.

[24]  R. Hynes,et al.  Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins , 1998, Cell.

[25]  T. Byzova,et al.  Role of integrin alpha(v)beta3 in vascular biology. , 1998, Thrombosis and haemostasis.

[26]  S. Mandriota,et al.  Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. , 1998, Circulation research.

[27]  Asim Khwaja,et al.  Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway , 1997, The EMBO journal.

[28]  Ulrich Keilholz,et al.  Immunohistochemical analysis of integrin αvβ3 expression on tumor‐associated vessels of human carcinomas , 1997 .

[29]  D. Ruiter,et al.  Immunohistochemical analysis of integrin alpha vbeta3 expression on tumor-associated vessels of human carcinomas. , 1997, International journal of cancer.

[30]  J. Flynn,et al.  Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization. , 1996, Survey of ophthalmology.

[31]  Chandra L. Theesfeld,et al.  Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[32]  M. Detmar,et al.  Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. , 1996, The American journal of pathology.

[33]  D. Cheresh,et al.  Transient functional expression of alphaVbeta 3 on vascular cells during wound repair. , 1996, The American journal of pathology.

[34]  H. Hammes,et al.  Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor–type integrins inhibits retinal neovascularization , 1996, Nature Medicine.

[35]  G. Davis,et al.  An alpha 2 beta 1 integrin-dependent pinocytic mechanism involving intracellular vacuole formation and coalescence regulates capillary lumen and tube formation in three-dimensional collagen matrix. , 1996, Experimental cell research.

[36]  R. Montesano,et al.  Three-Dimensional In Vitro Assay of Endothelial Cell Invasion and Capillary Tube Morphogenesis , 1996 .

[37]  J. Martínez,et al.  An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice. , 1995, Journal of cell science.

[38]  D. Cheresh,et al.  An antagonist of integrin alpha v beta 3 prevents maturation of blood vessels during embryonic neovascularization. , 1995, Journal of cell science.

[39]  D. Cheresh,et al.  Integrin α v β 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels , 1994, Cell.

[40]  E. Brown,et al.  Basic Fibroblast Growth Factor Increases Expression of the αvβ3 Integrin Complex on Human Microvascular Endothelial Cells , 1994 .

[41]  D. Cheresh,et al.  Requirement of vascular integrin alpha v beta 3 for angiogenesis. , 1994, Science.

[42]  D. Cheresh,et al.  Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. , 1994, Cell.

[43]  E. Brown,et al.  Basic fibroblast growth factor increases expression of the alpha v beta 3 integrin complex on human microvascular endothelial cells. , 1994, The Journal of investigative dermatology.

[44]  J. Gamble,et al.  Regulation of in vitro capillary tube formation by anti-integrin antibodies , 1993, The Journal of cell biology.

[45]  L. Orci,et al.  Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. , 1992, Biochemical and biophysical research communications.

[46]  C. Basson,et al.  Differential modulation of vascular cell integrin and extracellular matrix expression in vitro by TGF‐β1 correlates with reciprocal effects on cell migration+ , 1992 .

[47]  L. Orci,et al.  Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors , 1987, Journal of cellular physiology.

[48]  L. Orci,et al.  Tumor-promoting phorbol esters induce angiogenesis in vitro , 1985, Cell.

[49]  J. Folkman.  Tumor angiogenesis. , 1985, Advances in cancer research.

[50]  S. Silverstein,et al.  Cultured endothelial cell monolayers that restrict the transendothelial passage of macromolecules and electrical current , 1984, The Journal of cell biology.

[51]  E. Levine,et al.  Human endothelial cells: use of heparin in cloning and long-term serial cultivation. , 1983, Science.