Flow-injection analysis in clinical chemistry.

Flow-injection is the most recent addition to the techniques used in automatic analysis. In the simplest form, the sample is injected as a discrete slug into a stream of reagent flowing in a narrow-bore tube. Various sampling valves have been used in order to achieve full mechanization, but are not ideal for clinical analyses since they are wasteful of sample. An economical alternative has been developed which is based on the precise aspiration of sample by a probe. Applications of FIA and this modification in particular to clinical chemistry are discussed.

[1]  D. Betteridge,et al.  The determination of glyosbol in water by flow-injection analysis - a novel way of measuring viscosity. , 1976, Talanta.

[2]  P. E. Hare,et al.  Rapid analysis of discrete samples: the use of nonsegmented, continuous flow. , 1976, Analytical biochemistry.

[3]  G. Beecher,et al.  Automated multiple flow-injection analysis in clinical chemistry: determination of albumin with bromcresol green. , 1980, Clinical chemistry.

[4]  R. Sherwood,et al.  Zinc and Copper Determination in Microsamples of Serum by Flow Injection and Atomic Absorption Spectroscopy , 1982, Annals of clinical biochemistry.

[5]  J. Ruzicka,et al.  Enzymatic determination of urea in serum based on pH measurement with the flow injection method. , 1979, Analytical chemistry.

[6]  James N. Miller,et al.  Flow injection analysis with a fluorimetric detector for determinations of glycine and albumin , 1979 .

[7]  H. Baadenhuijsen,et al.  Determination of total CO2 in plasma by automated flow-injection analysis. , 1979, Clinical chemistry.

[8]  J. Ruzicka,et al.  Flow injection analysis. principles, applications and trends , 1980 .

[9]  H. Poppe,et al.  Dispersion in open tubes and tubes packed with large glass beads , 1981 .

[10]  G. Gerhardt,et al.  Determination of diffusion coefficients by flow injection analysis , 1982 .

[11]  I. Karube,et al.  Determination of lactate dehydrogenase in serum by using a pyruvate sensor , 1982 .

[12]  B. Rietz,et al.  Flow injection analysis: Part VIII. Determination of glucose in blood serum with glucose dehydrogenase , 1977 .

[13]  S. Ramasamy,et al.  Flow injection (closed-loop configuration) catalytic determination of copper in human blood serum , 1981 .

[14]  G D Christian,et al.  Homogeneous enzymatic fluorescence immunoassay of serum IgG by continuous flow-injection analysis. , 1982, Talanta.

[15]  Horacio A. Mottola,et al.  Enzymic substrate determination in closed flow-through systems by sample injection and amperometric monitoring of dissolved oxygen levels , 1978 .

[16]  J. Ruzicka,et al.  Flow injection analysis : Part VI. The determination of phosphate and chloride in blood serum by dialysis and sample dilution , 1976 .

[17]  Leif G. Anderson,et al.  Simultaneous spectrophotometric determination of nitrite and nitrate by flow injection analysis , 1979 .

[18]  J. Miller,et al.  Studies of drug—protein binding interactions by flow injection analysis with fluorimetric detection , 1983 .

[19]  J. Ruzicka,et al.  Flow injection analyses , 1975 .

[20]  J Morgon,et al.  Controlled dispersion analysis: flow-injection analysis without injection. , 1983, Clinical chemistry.

[21]  J. Janata,et al.  Comparison of sample injection systems for flow injection analysis , 1983 .

[22]  B. Reis,et al.  A new device for improving sensitivity and stabilization in flow-injection analysis , 1978 .

[23]  Elo Harald Hansen,et al.  Selectivity in flow injection analysis , 1983 .

[24]  L. Skeggs.  An automatic method for colorimetric analysis. , 1957, American journal of clinical pathology.

[25]  R. Sherwood,et al.  Serum Iron and Total Iron-Binding Capacity Determination by Flow-Injection Analysis with Atomic Absorption Detection , 1983, Annals of clinical biochemistry.

[26]  P. Worsfold,et al.  Simultaneous multi-element analysis of blood serum by flow injection - inductively coupled plasma atomic-emission spectrometry. , 1984, The Analyst.

[27]  R. Tijssen.  Axial dispersion and flow phenomena in helically coiled tubular reactors for flow analysis and chromatography , 1980 .

[28]  R. Sherwood,et al.  Direct Determination of Calcium and Magnesium in Serum Using Flow-Injection Analysis and Atomic Absorption Spectroscopy , 1984, Annals of clinical biochemistry.

[29]  D. Higgs,et al.  Laminar dispersion in flow-injection analysis. , 1981, Talanta.

[30]  F. Krug,et al.  Merging zones in flow injection analysis , 1978 .

[31]  J. Kawase.  Automated determination of cationic surfactants by flow injection analysis based on ion-pair extraction , 1980 .

[32]  G. Christian,et al.  Flow injection analysis-atomic absorption determination of serum zinc. , 1984, Clinica chimica acta; international journal of clinical chemistry.

[33]  D. A. Newton,et al.  An automated viscometer based on high-precision flow injection analysis. Part II. Measurement of viscosity and diffusion coefficients , 1983 .

[34]  G. Beecher,et al.  Determination of first-order reaction rate constants by flow injection analysis , 1984 .

[35]  Jens Mindegaard.  Flow multi-injection analysis—a system for the analysis of highly concentrated samples without prior dilution , 1979 .

[36]  N. Anderson.  Analytical techniques for cell fractions. XVI. Preparation of protein-free supernatants with a "Z"-path rotor. , 1969, Analytical biochemistry.

[37]  J. Ruzicka,et al.  Flow Injection Analysis of Glucose in Human Serum by Chemiluminescence , 1982 .

[38]  J. Savory,et al.  Use of a flow-injection sample manipulator as an interface between a "high-performance" liquid chromatograph and an atomic absorption spectrophotometer. , 1981, Clinical chemistry.

[39]  J. Kawase,et al.  Determination of anionic surfactants by flow injection analysis based on ion-pair extraction , 1979 .

[40]  J. Ruzicka,et al.  Flow injection analysis for calcium in serum, water and waste waters by spectrophotometry and by ion-selective electrode , 1978 .

[41]  D. J. Curran,et al.  Flow injection analysis with reticulated vitreous carbon flow-through electrodes , 1979 .

[42]  R. Sherwood,et al.  Direct determination of therapeutic concentrations of lithium in serum by flow-injection analysis with atomic absorption spectroscopic detection. , 1982, Clinical chemistry.

[43]  B. Rocks,et al.  FLow-injection analysis: a new approach to quantitative measurements in clinical chemistry. , 1982, Clinical chemistry.

[44]  Mark E. Meyerhoff,et al.  Flow Injection Determination of Ammonia-N Using Polymer Membrane Electrode-based Gas Sensing System , 1981 .

[45]  K. Stewart.  Depulsing system for positive displacement pumps , 1977 .

[46]  J. W. Bridges,et al.  Automation of an energy-transfer immunoassay by using stopped-flow injection analysis with merging zones , 1980 .

[47]  B. Fields,et al.  Kinetic treatment of unsegmented flow systems : Part 1. Subjective and semiquantitative evaluations of flow-injection systems with gradient chamber , 1981 .

[48]  Elo Harald Hansen,et al.  Flow injection analysis : Part X. theory, techniques and trends , 1978 .

[49]  B. Karlberg,et al.  Extraction based on the flow-injection principle: Part 2. Determination of codeine as the picrate ion-pair in acetylsalicylic acid tablets , 1979 .