- year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis ( PARTNER 1 ) : a randomised controlled trial

Methods We did this randomised controlled trial at 21 experienced valve centres in Canada, Germany, and the USA. We enrolled patients with severe symptomatic inoperable aortic stenosis and randomly assigned (1:1) them to transfemoral TAVR or to standard treatment, which often included balloon aortic valvuloplasty. Patients and their treating physicians were not masked to treatment allocation. The randomisation was done centrally, and sites learned of the assignment only after a patient had been screened, consented, and entered into the database. The primary outcome of the trial was all-cause mortality at 1 year in the intention-to-treat population, here we present the prespecifi ed fi ndings after 5 years. This study is registered with ClinicalTrials.gov, number NCT00530894.

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