Differential oncogenic potential of activated RAS isoforms in melanocytes

[1]  L. Chin,et al.  Malignant melanoma: genetics and therapeutics in the genomic era. , 2006, Genes & development.

[2]  Todd R. Golub,et al.  BRAF mutation predicts sensitivity to MEK inhibition , 2006, Nature.

[3]  B. Williams,et al.  Essential role for Ras signaling in glioblastoma maintenance. , 2005, Cancer research.

[4]  A. Trumpp,et al.  Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. , 2005, Cancer research.

[5]  K. Giehl Oncogenic Ras in tumour progression and metastasis , 2005, Biological chemistry.

[6]  R. Sears The Life Cycle of C-Myc: From Synthesis to Degradation , 2004, Cell cycle.

[7]  Ying Qi,et al.  Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization* , 2003, Journal of Biological Chemistry.

[8]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[9]  G. Hart,et al.  Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens. , 2002, The Journal of biological chemistry.

[10]  L. Chin,et al.  p16(Ink4a) in melanocyte senescence and differentiation. , 2002, Journal of the National Cancer Institute.

[11]  M. Lindstrom,et al.  Advances in Brief Regions of Hand KRas That Provide Organ Specificity / Potency in Mammary Cancer Induction 1 , 2002 .

[12]  J. Hancock,et al.  Compartmentalization of Ras proteins. , 2001, Journal of cell science.

[13]  M. Malumbres,et al.  Targeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and Development , 2001, Molecular and Cellular Biology.

[14]  D. Botstein,et al.  A gene expression database for the molecular pharmacology of cancer , 2000, Nature Genetics.

[15]  M. Castellano,et al.  Genes involved in melanoma: an overview of INK4a and other loci. , 1999, Melanoma research.

[16]  J. Hancock,et al.  Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase* , 1998, The Journal of Biological Chemistry.

[17]  Richard A. Ashmun,et al.  Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF , 1997, Cell.

[18]  L. Chin,et al.  Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. , 1997, Genes & development.

[19]  Jun Miyoshi,et al.  K-Ras is essential for the development of the mouse embryo , 1997, Oncogene.

[20]  D. Melton,et al.  A molecular mechanism for the effect of lithium on development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[21]  L. Chin,et al.  Role of the INK4a Locus in Tumor Suppression and Cell Mortality , 1996, Cell.

[22]  J. Maher,et al.  Evidence for cell-specific differences in transformation by N-, H- and K-ras. , 1995, Oncogene.

[23]  R. Kucherlapati,et al.  The murine N-ras gene is not essential for growth and development. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[24]  K. Urabe,et al.  Melanin biosynthesis patterns following hormonal stimulation. , 1993, The Journal of biological chemistry.

[25]  G. Klein,et al.  Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential. , 1993, Oncogene.

[26]  Y. Nakamura,et al.  Genetic alterations during colorectal-tumor development. , 1988, The New England journal of medicine.

[27]  P. Leder,et al.  Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo , 1987, Cell.

[28]  D. Bennett,et al.  A line of non‐tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth , 1987, International journal of cancer.

[29]  Robert A. Weinberg,et al.  Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes , 1983, Nature.

[30]  C. Warneke,et al.  Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. , 2006, The Journal of investigative dermatology.

[31]  Alex E. Lash,et al.  Gene Expression Omnibus: NCBI gene expression and hybridization array data repository , 2002, Nucleic Acids Res..