Targeting pyroptosis as a preventive and therapeutic approach for stroke

[1]  G. Stoll,et al.  Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice , 2023, Journal of Neuroinflammation.

[2]  Wei Jiang,et al.  Chrysophanol facilitates long-term neurological recovery through limiting microglia-mediated neuroinflammation after ischemic stroke in mice. , 2022, International immunopharmacology.

[3]  Tingxu Yan,et al.  Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway , 2022, Metabolic Brain Disease.

[4]  Qian Zhang,et al.  Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner , 2022, Experimental Neurology.

[5]  Weifeng Su,et al.  A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis , 2022, Frontiers in Immunology.

[6]  K. Schroder,et al.  NLRP3 and pyroptosis blockers for treating inflammatory diseases. , 2022, Trends in pharmacological sciences.

[7]  J. Lieberman,et al.  Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis , 2022, Nature.

[8]  A. Abramov,et al.  Interaction of Mitochondrial Calcium and ROS in Neurodegeneration , 2022, Cells.

[9]  Weitao Yan,et al.  Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies , 2022, Neural regeneration research.

[10]  Canwen Liu,et al.  Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2 , 2021, Oxidative medicine and cellular longevity.

[11]  Qianyi Gong,et al.  Microglia Polarization from M1 toward M2 Phenotype Is Promoted by Astragalus Polysaccharides Mediated through Inhibition of miR-155 in Experimental Autoimmune Encephalomyelitis , 2021, Oxidative medicine and cellular longevity.

[12]  K. Tufekci,et al.  Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice , 2021, Frontiers in Immunology.

[13]  C. Lenahan,et al.  Rh-CXCL-12 Attenuates Neuronal Pyroptosis after Subarachnoid Hemorrhage in Rats via Regulating the CXCR4/NLRP1 Pathway , 2021, Oxidative medicine and cellular longevity.

[14]  Wei Ma,et al.  Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway , 2021, Annals of translational medicine.

[15]  J. Lieberman,et al.  NLRP3 inflammasome activation triggers gasdermin D–independent inflammation , 2021, Science Immunology.

[16]  Jing Luo,et al.  6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy. , 2021, International immunopharmacology.

[17]  Yingnan Zhao,et al.  Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury through up-regulating PPAR-γ to suppress NF-κB-mediated pyroptosis , 2021, Brain Research Bulletin.

[18]  Chunrong Tao,et al.  TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage , 2021, Journal of Neuroinflammation.

[19]  R. Zhou,et al.  NLRP3 inflammasome activation and cell death , 2021, Cellular & Molecular Immunology.

[20]  Tingting Wang,et al.  Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis , 2021, Frontiers in Immunology.

[21]  J. Lieberman,et al.  The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia , 2021, Science.

[22]  Xiufeng Chen,et al.  Schisandrin B Attenuates Airway Inflammation and Airway Remodeling in Asthma by Inhibiting NLRP3 Inflammasome Activation and Reducing Pyroptosis , 2021, Inflammation.

[23]  M. Ruan,et al.  Synergic Neuroprotection Between Ligusticum Chuanxiong Hort and Borneol Against Ischemic Stroke by Neurogenesis via Modulating Reactive Astrogliosis and Maintaining the Blood–Brain Barrier , 2021, Frontiers in Pharmacology.

[24]  Z. Xia,et al.  Supplemental N-3 Polyunsaturated Fatty Acids Limit A1-Specific Astrocyte Polarization via Attenuating Mitochondrial Dysfunction in Ischemic Stroke in Mice , 2021, Oxidative medicine and cellular longevity.

[25]  Yang Yang,et al.  SIRT1/PGC-1α signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells. , 2021, European journal of pharmacology.

[26]  Xiao-Lu Cao,et al.  Baicalin Inhibits NLRP3 Inflammasome Activity Via the AMPK Signaling Pathway to Alleviate Cerebral Ischemia-Reperfusion Injury , 2021, Inflammation.

[27]  Xianming Deng,et al.  RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor , 2021, Cellular & Molecular Immunology.

[28]  A. Grünewald,et al.  Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective , 2021, Frontiers in Endocrinology.

[29]  P. Lei,et al.  Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications , 2021, Medicinal research reviews.

[30]  Fei Li,et al.  Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis. , 2021, Pharmacological research.

[31]  J. Lieberman,et al.  Gasdermin D pore structure reveals preferential release of mature interleukin-1 , 2021, Nature.

[32]  X. Qin,et al.  Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites , 2021, Acta Pharmacologica Sinica.

[33]  E. Latz,et al.  Necroptosis, pyroptosis and apoptosis: an intricate game of cell death , 2021, Cellular & Molecular Immunology.

[34]  Xiang Chen,et al.  Pyroptosis: mechanisms and diseases , 2021, Signal Transduction and Targeted Therapy.

[35]  G. Fink,et al.  Osteopontin regulates proliferation, migration, and survival of astrocytes depending on their activation phenotype , 2021, Journal of neuroscience research.

[36]  T. Kanneganti,et al.  NLRP3 inflammasome in cancer and metabolic diseases , 2021, Nature Immunology.

[37]  J. Lieberman,et al.  Channelling inflammation: gasdermins in physiology and disease , 2021, Nature reviews. Drug discovery.

[38]  D. Ouyang,et al.  Inhibition of NLRP3 Inflammasome Activation and Pyroptosis in Macrophages by Taraxasterol Is Associated With Its Regulation on mTOR Signaling , 2021, Frontiers in Immunology.

[39]  Xiang Gao,et al.  Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock , 2021, European journal of immunology.

[40]  C. Stehlik,et al.  An overview of the non-canonical inflammasome. , 2020, Molecular aspects of medicine.

[41]  Á. Chamorro,et al.  The future of neuroprotection in stroke , 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

[42]  W. Lu,et al.  Rosmarinic Acid Regulates Microglial M1/M2 Polarization via the PDPK1/Akt/HIF Pathway Under Conditions of Neuroinflammation , 2020, Inflammation.

[43]  Minghuan Wang,et al.  Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury , 2020, Journal of neuroinflammation.

[44]  A. Strasser,et al.  Emerging connectivity of programmed cell death pathways and its physiological implications , 2020, Nature Reviews Molecular Cell Biology.

[45]  S. Shaffer,et al.  Succination inactivates gasdermin D and blocks pyroptosis , 2020, Science.

[46]  J. Tainer,et al.  PD-L1-Mediated Gasdermin C Expression Switches Apoptosis to Pyroptosis in Cancer Cells and Facilitates Tumor Necrosis , 2020, Nature Cell Biology.

[47]  T. Kanneganti,et al.  The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis) , 2020, Immunological reviews.

[48]  Yun Xu,et al.  6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway. , 2020, European journal of pharmacology.

[49]  Bowen Zhou,et al.  Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. , 2020, Immunity.

[50]  Y. Zhang,et al.  Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro , 2020, Journal of neurochemistry.

[51]  Ranran Wang,et al.  Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke , 2020, Nature Communications.

[52]  Yaxue Zhao,et al.  Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis. , 2020, Pharmacological research.

[53]  J. Kou,et al.  Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation , 2020, Redox biology.

[54]  Yilin Yang,et al.  Astilbin protects against cerebral ischaemia/reperfusion injury by inhibiting cellular apoptosis and ROS-NLRP3 inflammasome axis activation. , 2020, International immunopharmacology.

[55]  G. Dubyak,et al.  N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis , 2020, Nature Communications.

[56]  L. Shen,et al.  Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells , 2020, Science.

[57]  Wugang Hou,et al.  Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte , 2020, Journal of Neuroinflammation.

[58]  Hongping Chen,et al.  Inhibition of the NLRP3 inflammasome reduces brain edema and regulates the distribution of aquaporin-4 after cerebral ischaemia-reperfusion. , 2020, Life sciences.

[59]  J. Lukens,et al.  AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment , 2020, Nature.

[60]  J. Lieberman,et al.  FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation , 2020, Nature Immunology.

[61]  K. Strebhardt,et al.  Caspase-8: The double-edged sword. , 2020, Biochimica et biophysica acta. Reviews on cancer.

[62]  Junying Yuan,et al.  Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke , 2020, Proceedings of the National Academy of Sciences.

[63]  Zilin Li,et al.  Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis , 2020, Cell.

[64]  J. Lieberman,et al.  Gasdermin E suppresses tumor growth by activating anti-tumor immunity , 2020, Nature.

[65]  Z. You,et al.  Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage , 2020, Cell Death & Disease.

[66]  W. Xiao,et al.  Ginkgo diterpene lactones inhibit cerebral ischemia/reperfusion induced inflammatory response in astrocytes via TLR4/NF-κB pathway in rats. , 2020, Journal of ethnopharmacology.

[67]  Hao Wu,et al.  Mechanism and Regulation of Gasdermin-Mediated Cell Death. , 2019, Cold Spring Harbor perspectives in biology.

[68]  Z. Dong,et al.  Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia–Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models , 2019, Neurochemical Research.

[69]  Y. Anraku,et al.  Nanomaterial-based blood-brain-barrier (BBB) crossing strategies. , 2019, Biomaterials.

[70]  T. Kanneganti,et al.  ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) , 2019, Front. Cell. Infect. Microbiol..

[71]  A. Amer,et al.  Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation , 2019, Front. Immunol..

[72]  F. Shao,et al.  The gasdermins, a protein family executing cell death and inflammation , 2019, Nature Reviews Immunology.

[73]  M. Pasparakis,et al.  Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis , 2019, Nature.

[74]  B. Pickard,et al.  The Role of Neuronal NLRP1 Inflammasome in Alzheimer’s Disease: Bringing Neurons into the Neuroinflammation Game , 2019, Molecular Neurobiology.

[75]  Rohit Reja,et al.  Activity of caspase-8 determines plasticity between cell death pathways , 2019, Nature.

[76]  G. Donnan,et al.  Ischaemic stroke , 2019, Nature Reviews Disease Primers.

[77]  Zhanfei Li,et al.  Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis , 2019, Brain, Behavior, and Immunity.

[78]  C. Day,et al.  MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition , 2019, Nature Chemical Biology.

[79]  X. Jin,et al.  The Role of Astragaloside IV against Cerebral Ischemia/Reperfusion Injury: Suppression of Apoptosis via Promotion of P62-LC3-Autophagy , 2019, Molecules.

[80]  P. Kubes,et al.  The Neutrophil's Role During Health and Disease. , 2019, Physiological reviews.

[81]  Zhenzhong Wang,et al.  Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt/Nrf2 pathway in vitro and in vivo , 2019, Cell Stress and Chaperones.

[82]  P. Brož,et al.  ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation , 2018, Science.

[83]  Juan I. Young,et al.  Resveratrol Preconditioning Induces Genomic and Metabolic Adaptations within the Long-Term Window of Cerebral Ischemic Tolerance Leading to Bioenergetic Efficiency , 2018, Molecular Neurobiology.

[84]  J. Vince,et al.  Pyroptosis versus necroptosis: similarities, differences, and crosstalk , 2018, Cell Death & Differentiation.

[85]  Yunman Li,et al.  Berberine attenuates ischemia–reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation , 2018, Acta Pharmacologica Sinica.

[86]  H. Das,et al.  Current advances in ischemic stroke research and therapies. , 2018, Biochimica et biophysica acta. Molecular basis of disease.

[87]  G. Dubyak,et al.  Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis , 2018, Science Immunology.

[88]  K. Schroder,et al.  Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps , 2018, Science Immunology.

[89]  J. Weitz,et al.  Fibrinolysis: strategies to enhance the treatment of acute ischemic stroke , 2018, Journal of thrombosis and haemostasis : JTH.

[90]  Ke Wang,et al.  Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats , 2018, Genes & diseases.

[91]  E. Parthoens,et al.  Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture , 2018, Cell Death & Differentiation.

[92]  A. Tolkovsky,et al.  Neuronal Cell Death. , 2018, Physiological reviews.

[93]  Jelena S. Bezbradica,et al.  Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity , 2018, The Journal of experimental medicine.

[94]  Ben A. Barres,et al.  Normal aging induces A1-like astrocyte reactivity , 2018, Proceedings of the National Academy of Sciences.

[95]  L. Joosten,et al.  OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation , 2018, Proceedings of the National Academy of Sciences.

[96]  Hao Wu,et al.  The Pore‐Forming Protein Gasdermin D Regulates Interleukin‐1 Secretion from Living Macrophages , 2018, Immunity.

[97]  M. Bennett,et al.  Blood-brain barrier dysfunction and recovery after ischemic stroke , 2017, Progress in Neurobiology.

[98]  Chaoqian Xu,et al.  Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis , 2018, Cell Death & Disease.

[99]  Qingsong Liu,et al.  Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders , 2017, The Journal of experimental medicine.

[100]  Yong Ho Kim,et al.  Astrocytic Neuroligins Control Astrocyte Morphogenesis and Synaptogenesis , 2017, Nature.

[101]  Ji-xian Wang,et al.  The biphasic function of microglia in ischemic stroke , 2017, Progress in Neurobiology.

[102]  Yanghao Hou,et al.  Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1‐dependent autophagy induction , 2017, International immunopharmacology.

[103]  Q. Xiao,et al.  Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury , 2017, Brain, Behavior, and Immunity.

[104]  Jun-li Chen,et al.  Ferulic acid attenuates brain microvascular endothelial cells damage caused by oxygen-glucose deprivation via punctate-mitochondria-dependent mitophagy , 2017, Brain Research.

[105]  M. Colonna,et al.  Microglia Function in the Central Nervous System During Health and Neurodegeneration. , 2017, Annual review of immunology.

[106]  Xiaoning Han,et al.  Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia , 2017, Brain, Behavior, and Immunity.

[107]  Yun Gu,et al.  Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats , 2016, Molecular Neurobiology.

[108]  J. Kou,et al.  Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway , 2016, International journal of molecular sciences.

[109]  H. Stahlberg,et al.  GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death , 2016, The EMBO journal.

[110]  J. Lieberman,et al.  Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores , 2016, Nature.

[111]  Qing-Wu Yang,et al.  Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke , 2016, Progress in Neurobiology.

[112]  R. Keep,et al.  Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury , 2016, Nature Communications.

[113]  Z. Wang,et al.  A Neuroprotective Sericin Hydrogel As an Effective Neuronal Cell Carrier for the Repair of Ischemic Stroke. , 2015, ACS applied materials & interfaces.

[114]  Luyong Zhang,et al.  Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation , 2015, Brain, Behavior, and Immunity.

[115]  S. Kummerfeld,et al.  Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling , 2015, Nature.

[116]  Si Ming Man,et al.  Regulation of inflammasome activation , 2015, Immunological reviews.

[117]  R. Leak,et al.  Microglial and macrophage polarization—new prospects for brain repair , 2015, Nature Reviews Neurology.

[118]  J. Kong,et al.  Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke. , 2013, European journal of pharmacology.

[119]  D. Lee,et al.  Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[120]  K. O. Elliston,et al.  A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes , 1992, Nature.