Fetal Maternal Heart Rate Entrainment under Controlled Maternal Breathing

There is evidence that, during pregnancy, fetal and maternal cardiac activity may coordinate over short periods of time. Aim of this work was to investigate whether controlled paced maternal respiration has an effect on the occurrence of fetal-maternal heart rate synchronization. In 6 healthy pregnant women (34th - 40th week of gestation) we obtained simultaneous 5 min. fetal and maternal magnetocardiograms (MCG) at maternal respiration rates of 10, 12, 15 and 20 cpm as well as under spontaneous breathing. Fetal and maternal RR interval time series were constructed for each MCG data set and synchrograms were obtained using the stroboscopic technique. Synchronization epochs (SE) >10 s were identified in these original data. Furthermore, "twin surrogate" data sets of the maternal MCG were constructed, combined with the fetal MCG data and SE were identified in these surrogate data. In the original data, there was a higher number of SE found at 20 cpm respiratory rate compared to other rates. This was not evident in the surrogate data. Fewer SE were found at lower rates (10 cpm) both in the original and surrogate data. Examination of the phase of fetal R peaks relative to maternal RR cycles showed that in the original data there was a clear phase preference in the 20 cpm data. This preference was not found in the surrogate data. These results were reproduced on the basis of a mathematical model incorporating the essential elements of fetal and maternal heart rates and their variability. We conclude that fetal-maternal heart rate entrainment may be induced by high maternal respiratory rates and that chance fetal-maternal heart rate coordination may be inhibited by low maternal respiratory rates.

[1]  S Cerutti,et al.  Power spectral analysis of the heart rate of the human fetus at 26 and 36 weeks of gestation. , 1989, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[2]  Reinhold Kliegl,et al.  Twin surrogates to test for complex synchronisation , 2006 .

[3]  G. Hankins,et al.  Prolonged Fetal Bradycardia Secondary to Maternal Hypothermia in Response to Urosepsis , 1997, American journal of perinatology.

[4]  M. Mirmiran,et al.  Fetal and maternal diurnal rhythms during the third trimester of normal pregnancy: outcomes of computerized analysis of continuous twenty-four-hour fetal heart rate recordings. , 1998, American journal of obstetrics and gynecology.

[5]  G. Visser,et al.  The effects of maternal hyperoxia on fetal breathing movements, body movements and heart rate variation in growth retarded fetuses. , 1991, Early human development.

[6]  J. Kurths,et al.  Heartbeat synchronized with ventilation , 1998, Nature.

[7]  J. Patrick,et al.  Influence of maternal heart rate and gross fetal body movements on the daily pattern of fetal heart rate near term. , 1982, American journal of obstetrics and gynecology.

[8]  D. Grönemeyer,et al.  Is there evidence of fetal-maternal heart rate synchronization? , 2003, BMC Physiology.

[9]  P. Van Leeuwen,et al.  Modeling fetal--maternal heart-rate interaction , 2009, IEEE Engineering in Medicine and Biology Magazine.

[10]  L. A. Wolfe,et al.  Effects of acute and chronic maternal exercise on fetal heart rate. , 1994, Journal of applied physiology.

[11]  S Akselrod,et al.  Does synchronization reflect a true interaction in the cardiorespiratory system? , 2002, Medical engineering & physics.