Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.
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[1] N Loveridge,et al. Identification of apoptotic changes in osteocytes in normal and pathological human bone. , 1997, Bone.
[2] E. Burger,et al. Inhibiting and stimulating effects of TGF‐β1 on osteoclastic bone resorption in fetal mouse bone organ cultures , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[3] Joie Davis,et al. Mutations of CTSK Result in Pycnodysostosis via a Reduction in Cathepsin K Protein , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[4] K. Korach,et al. Effect of testosterone and estradiol in a man with aromatase deficiency. , 1997, The New England journal of medicine.
[5] D. Lacey,et al. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. , 1999, Endocrinology.
[6] S. Rudikoff,et al. A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo1. , 1999, Endocrinology.
[7] C. Christiansen,et al. Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting. , 2002, Bone.
[8] B. Fingleton,et al. Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations , 2002, Science.
[9] E. Jimi,et al. Regulation of Osteoclast Function , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[10] L. Klenerman,et al. ANABOLIC EFFECT OF LOW DOSES OF A FRAGMENT OF HUMAN PARATHYROID HORMONE ON THE SKELETON IN POSTMENOPAUSAL OSTEOPOROSIS , 1976, The Lancet.
[11] G. Stein,et al. Osteocalcin gene promoter: Unlocking the secrets for regulation of osteoblast growth and differentiation , 1998, Journal of cellular biochemistry.
[12] D. Goltzman,et al. In vivo distribution of parathyroid hormone receptors in bone: evidence that a predominant osseous target cell is not the mature osteoblast. , 1988, Endocrinology.
[13] Makoto Sato,et al. Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts , 1997, Cell.
[14] W. Ambrosius,et al. Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. , 1997, Bone.
[15] A. Boskey,et al. Matrix proteins and mineralization: an overview. , 1996, Connective tissue research.
[16] P. Roberson,et al. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. , 1999, The Journal of clinical investigation.
[17] L. Melton,et al. Evidence for two distinct syndromes of involutional osteoporosis. , 1983, The American journal of medicine.
[18] G. Wesolowski,et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[19] S. Srivastava,et al. Androgens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factor. , 2001, Endocrinology.
[20] Z. Wu,et al. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids , 1996, Molecular and cellular biology.
[21] J. Glowacki,et al. In vitro secretion of cytokines by human bone marrow: effects of age and estrogen status. , 1998, The Journal of clinical endocrinology and metabolism.
[22] E. Opas,et al. The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. , 1993, The Journal of clinical investigation.
[23] A. Friedenstein,et al. STROMAL CELLS RESPONSIBLE FOR TRANSFERRING THE MICROENVIRONMENT OF THE HEMOPOIETIC TISSUES: Cloning In Vitro and Retransplantation In Vivo , 1974, Transplantation.
[24] H. Fleisch. Bisphosphonates: Mechanisms of Action , 1998 .
[25] G. David Roodman,et al. Paget disease of bone , 2012, Radiopaedia.org.
[26] C. Christiansen,et al. Biochemical markers can predict the response in bone mass during alendronate treatment in early postmenopausal women. Alendronate Osteoporosis Prevention Study Group. , 1999, Bone.
[27] L. Banks,et al. Effect of degenerative spinal and aortic calcification on bone density measurements in post‐menopausal women: links between osteoporosis and cardiovascular disease? , 1994, European journal of clinical investigation.
[28] I. Semba,et al. Higher osteoclastic demineralization and highly mineralized cement lines with osteocalcin deposition in a mandibular cortical bone of autosomal dominant osteopetrosis type II: ultrastructural and undecalcified histological investigations. , 2000, Bone.
[29] S. Razzouk,et al. Rac-GTPase, osteoclast cytoskeleton and bone resorption. , 1999, European journal of cell biology.
[30] A. Boyde,et al. Marrow stromal (Western-Bainton) cells: identification, morphometry, confocal imaging and changes in disease. , 1993, Bone.
[31] T. Komori,et al. Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF). , 1998, Biochemical and biophysical research communications.
[32] A. Parfitt,et al. Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[33] G. Passeri,et al. 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. , 1992, The Journal of clinical investigation.
[34] S. Marks,et al. The origin of osteoclasts: evidence, clinical implications and investigative challenges of an extra-skeletal source. , 1983, Journal of oral pathology.
[35] R. Scandurra,et al. The selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro. , 2002, Bone.
[36] D. Goltzman,et al. Discoveries, drugs and skeletal disorders , 2002, Nature Reviews Drug Discovery.
[37] D. Bainton,et al. Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors , 1979, The Journal of experimental medicine.
[38] L. Quarles,et al. Guanine nucleotide binding‐protein coupled signaling pathway regulation of osteoblast‐mediated bone formation , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[39] R. Eastell,et al. Cancellous bone remodeling in type i (postmenopausal) osteoporosis: Quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels , 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[40] J. Loutit. Stem Cells—Their Identification and Characterisation , 1983, British Journal of Cancer.
[41] A. F. Stewart. PTHrP(1-36) as a skeletal anabolic agent for the treatment of osteoporosis. , 1996, Bone.
[42] B. Boyce,et al. Apoptosis in bone physiology and disease. , 1997, Molecular pathology : MP.
[43] V. Rosen,et al. Opposing effects by glucocorticoid and bone morphogenetic protein‐2 in fetal rat bone cell cultures , 1997, Journal of cellular biochemistry.
[44] D. Frank,et al. Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[45] P. Lakatos,et al. Serum interleukin-6 and bone metabolism in patients with thyroid function disorders. , 1997, The Journal of clinical endocrinology and metabolism.
[46] J. Hock. Stemming bone loss by suppressing apoptosis. , 1999, The Journal of clinical investigation.
[47] J. Wergedal,et al. Increases in number and size of osteoclasts in response to calcium or phosphorus deficiency in the rat. , 1975, Endocrinology.
[48] T. Sunyer,et al. Estrogen’s bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells , 1999 .
[49] D. Kioussis,et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. , 1991, The EMBO journal.
[50] P. Saftig,et al. The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[51] S. Brooks,et al. Relationship between estrogen structure and conformational changes in estrogen receptor/DNA complexes , 1995, The Journal of Steroid Biochemistry and Molecular Biology.
[52] J. Kragstrup,et al. A reconstruction of the remodelling cycle in normal human cortical iliac bone. , 1991, Bone and mineral.
[53] J. Heersche,et al. Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration. , 1982, Endocrinology.
[54] V. Rosen,et al. Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages , 1998, The Journal of cell biology.
[55] A. Parfitt,et al. Increased Adipogenesis and Myelopoiesis in the Bone Marrow of SAMP6, a Murine Model of Defective Osteoblastogenesis and Low Turnover Osteopenia , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[56] G. Yancopoulos,et al. Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells. , 1996, The Journal of clinical investigation.
[57] S. Kato,et al. Rapid activation of MAP kinase by estrogen in the bone cell line. , 1997, Biochemical and biophysical research communications.
[58] G. Mundy,et al. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β , 1996, Nature Medicine.
[59] J. Simpkins,et al. Phenolic A ring requirement for the neuroprotective effects of steroids , 1997, The Journal of Steroid Biochemistry and Molecular Biology.
[60] R. Baron,et al. Dissociation between bone resorption and bone formation in osteopenic transgenic mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[61] G. Wesolowski,et al. Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading. , 1997, Experimental cell research.
[62] S. C. Lin,et al. Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage. , 1998, Proceedings of the Association of American Physicians.
[63] Yuqiong Liang,et al. Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification , 1999, Nature Genetics.
[64] J. Compston,et al. Bone Remodeling and Structure in Postmenopausal Women Treated with Long-Term, High-Dose Estrogen Therapy , 1999, Osteoporosis International.
[65] T. Chambers,et al. Prostaglandin E2 cooperates with TRANCE in osteoclast induction from hemopoietic precursors: synergistic activation of differentiation, cell spreading, and fusion. , 1999, Endocrinology.
[66] J. Adachi,et al. Histomorphometric evidence for increased bone turnover without change in cortical thickness or porosity after 2 years of cyclical hPTH(1-34) therapy in women with severe osteoporosis. , 2000, Bone.
[67] P. Schlesinger,et al. Expression and Regulation of RAB3 Proteins in Osteoclasts and Their Precursors , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[68] M. Oursler,et al. Estrogen modulation of osteoclast lysosomal enzyme secretion , 1995, Journal of cellular biochemistry.
[69] Y. Bi,et al. Regulation of osteoclast activity. , 1999, Life sciences.
[70] D. Lacey,et al. Printed in U.S.A. Copyright © 1999 by The Endocrine Society Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in , 2022 .
[71] P. Roberson,et al. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. , 1999, The Journal of clinical investigation.
[72] F. Melsen,et al. A randomized study on the effects of estrogen/gestagen or high dose oral calcium on trabecular bone remodeling in postmenopausal osteoporosis. , 1990, Bone.
[73] J. Simpkins,et al. Nuclear estrogen receptor-independent neuroprotection by estratrienes: a novel interaction with glutathione , 1998, Neuroscience.
[74] R. Turner,et al. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. , 1995, Endocrinology.
[75] S. Morony,et al. osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. , 1998, Genes & development.
[76] H. Haugen,et al. Developmental abnormalities in mice transgenic for bovine oncostatin M , 1995, Molecular and cellular biology.
[77] F. Melsen,et al. Formation of osteoblast‐like cells from human mononuclear bone marrow cultures , 1991, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
[78] S. Teitelbaum,et al. Bone resorption by osteoclasts. , 2000, Science.
[79] S. Freytag,et al. Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells. , 1994, Genes & development.
[80] C. Watson,et al. Estrogen Receptor-α Detected on the Plasma Membrane of Aldehyde-Fixed GH3/B6/F10 Rat Pituitary Tumor Cells by Enzyme-Linked Immunocytochemistry. , 1999, Endocrinology.
[81] A. Boskey. Biomineralization: Conflicts, challenges, and opportunities , 1998, Journal of cellular biochemistry.
[82] P. Lehenkari,et al. Removal of osteoclast bone resorption products by transcytosis. , 1997, Science.
[83] Renny T. Franceschi,et al. Role of the α2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor* , 1998, The Journal of Biological Chemistry.
[84] S. McKnight,et al. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. , 1995, Genes & development.
[85] G. Roodman. Paget's disease and osteoclast biology. , 1996, Bone.
[86] T. Martin,et al. Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[87] L. Bonewald,et al. Role of active and latent transforming growth factor beta in bone formation. , 1994, Journal of cellular biochemistry.
[88] C Marcelli,et al. Markers of bone resorption predict hip fracture in elderly women: The EPIDOS prospective study , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[89] J Reeve,et al. Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial. , 1980, British medical journal.
[90] D. Lacey,et al. Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis1. , 1999, Endocrinology.
[91] G Shimamoto,et al. Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density , 1997, Cell.
[92] Hen-Li Chen,et al. Anabolic actions of parathyroid hormone during bone growth are dependent on c-fos. , 2002, Endocrinology.
[93] R. Hynes,et al. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. , 2000, The Journal of clinical investigation.
[94] A R Pettit,et al. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. , 2001, The American journal of pathology.
[95] B. Riggs,et al. Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[96] S. Teitelbaum,et al. Osteoclastic bone resorption by a polarized vacuolar proton pump. , 1989, Science.
[97] B. Riggs,et al. Avian osteoclasts as estrogen target cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[98] Michael C. Ostrowski,et al. The Microphthalmia Transcription Factor Regulates Expression of the Tartrate‐Resistant Acid Phosphatase Gene During Terminal Differentiation of Osteoclasts , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[99] M. Jourdan,et al. Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. , 1991, Blood.
[100] G. Karsenty,et al. Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation , 1997, Cell.
[101] B. Riggs,et al. Unitary Model of Osteoporosis Revisited , 1998 .
[102] J. Triffitt,et al. Adipocytic cells cultured from marrow have osteogenic potential. , 1991, Journal of cell science.
[103] S. Manolagas. Cellular and molecular mechanisms of osteoporosis , 1998, Aging.
[104] C. Christiansen,et al. Marked diurnal variation in urinary excretion of pyridinium cross-links in premenopausal women. , 1992, The Journal of clinical endocrinology and metabolism.
[105] R. Pacifici. Editorial: Cytokines, Estrogen, and Postmenopausal Osteoporosis-The Second Decade. , 1998, Endocrinology.
[106] M. Odeh,et al. Role of cytokines in rheumatoid arthritis. , 1998, Drug news & perspectives.
[107] P. Nijweide,et al. Function of osteocytes in bone , 1994, Journal of cellular biochemistry.
[108] Shi Wei,et al. Tumor Necrosis Factor α Regulatesα vβ5 Integrin Expression by Osteoclast Precursors in Vitro and in Vivo1. , 2000, Endocrinology.
[109] R. Evans,et al. PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL , 1998, Cell.
[110] M. Tavassoli. Fatty Involution of Marrow and the Role of Adipose Tissue in Hemopoiesis , 1989 .
[111] Abstract , 1952 .
[112] G. Yancopoulos,et al. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. , 1994, Science.
[113] H. Kishimoto. [Bisphosphonates: pharmacology and use in the treatment of osteoporosis]. , 2002, Nihon rinsho. Japanese journal of clinical medicine.
[114] H. Takayanagi,et al. Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. , 1999, Journal of Clinical Investigation.
[115] M. Whyte. Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization. , 1994, Endocrine reviews.
[116] J. Li,et al. Bisphosphonate Treatment Suppresses Not Only Stochastic Remodeling but Also the Targeted Repair of Microdamage , 2001, Calcified Tissue International.
[117] S. Manolagas. The role of IL-6 type cytokines and their receptors in bone. , 1998, Annals of the New York Academy of Sciences.
[118] Allan Bradley,et al. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice , 1991, Cell.
[119] W. Wiktor-Jedrzejczak,et al. Correction by CSF-1 of defects in the osteopetrotic op/op mouse suggests local, developmental, and humoral requirements for this growth factor. , 1991, Experimental hematology.
[120] R. Harland,et al. The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4 , 1996, Cell.
[121] J. Risteli,et al. Estrogen Reduces the Depth of Resorption Pits by Disturbing the Organic Bone Matrix Degradation Activity of Mature Osteoclasts. , 2001, Endocrinology.
[122] V. Han,et al. Regional variation of insulin-like growth factor-I gene expression in mature rat bone and cartilage. , 1994, Bone.
[123] V. Parikka,et al. Downregulation of Small GTPase Rab7 Impairs Osteoclast Polarization and Bone Resorption* 210 , 2001, The Journal of Biological Chemistry.
[124] O. Jaillon,et al. The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants. , 2000, Bone.
[125] J. Wrana,et al. The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor , 1996, Cell.
[126] W. O'Fallon,et al. Relationship of Bone Turnover to Bone Density and Fractures , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[127] T. Martin,et al. Coupling of Bone Resorption and Formation during Bone Remodeling , 2001 .
[128] 楢崎 雅司. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130 , 1994 .
[129] S. Manolagas. Bone marrow, cytokines, and bone remodeling , 1995 .
[130] Jill Moss,et al. Mesenchymal precursor cells in the blood of normal individuals , 2000, Arthritis Research & Therapy.
[131] D. Fisher,et al. Linking osteopetrosis and pycnodysostosis: Regulation of cathepsin K expression by the microphthalmia transcription factor family , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[132] R. Baron,et al. The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation/function. , 2001, Bone.
[133] D. Lacey,et al. The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts , 1999, The Journal of cell biology.
[134] R. Ziegler,et al. Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement. , 1995, The Journal of clinical endocrinology and metabolism.
[135] N. Franchimont,et al. Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage. , 1995, Endocrinology.
[136] M. Degli-Esposti. To die or not to die—the quest of the TRAIL receptors , 1999, Journal of leukocyte biology.
[137] Sheila J. Jones,et al. Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis. , 1996, Development.
[138] T. Serikawa,et al. Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain , 1999, Mammalian Genome.
[139] J. Caulfield,et al. Modulation of osteogenic cell ultrastructure by RS-23581, an analog of human parathyroid hormone (PTH)-related peptide-(1-34), and bovine PTH-(1-34). , 1995, Endocrinology.
[140] R. Gordon,et al. Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation. , 2001, The American journal of pathology.
[141] T. Pappas,et al. Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[142] R. Baron,et al. Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border , 1985, The Journal of cell biology.
[143] H. Frost. In vivo osteocyte death. , 1960, The Journal of bone and joint surgery. American volume.
[144] C. Christiansen,et al. Monitoring of alendronate treatment and prediction of effect on bone mass by biochemical markers in the early postmenopausal intervention cohort study. , 1999, The Journal of clinical endocrinology and metabolism.
[145] D L Lacey,et al. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[146] J. Bollerslev. Autosomal dominant osteopetrosis: bone metabolism and epidemiological, clinical, and hormonal aspects. , 1989, Endocrine reviews.
[147] P. Lips,et al. Bone Histomorphometric and Biochemical Marker Results of a 2‐Year Placebo‐Controlled Trial of Raloxifene in Postmenopausal Women , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[148] K. Mann,et al. Bone formation rate in older normal women: concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers. , 1988, The Journal of clinical endocrinology and metabolism.
[149] K. Ozono,et al. Increased IL-6-production by cells isolated from the fibrous bone dysplasia tissues in patients with McCune-Albright syndrome. , 1996, The Journal of clinical investigation.
[150] T. Latifi,et al. Reciprocal regulation of osteocalcin transcription by the homeodomain proteins Msx2 and Dlx5. , 1998, Biochemistry.
[151] Michael A. Banks,et al. Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption. , 1995, The Journal of clinical investigation.
[152] Sheila J. Jones,et al. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[153] A. Parfitt. Osteonal and hemi‐osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone , 1994, Journal of cellular biochemistry.
[154] Carla Palumbo,et al. Structure-function relationships in the osteocyte. , 1990 .
[155] T. Steiniche,et al. Changes in bone histomorphometry after long‐term treatment with intermittent, cyclic etidronate for postmenopausal osteoporosis , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[156] J. Gimble,et al. Osteoblastic gene expression during adipogenesis in hematopoietic supporting murine bone marrow stromal cells , 1993, Journal of cellular physiology.
[157] P. Roberson,et al. Transcriptional Activation of the p21 WAF1,CIP1,SDI1 Gene by Interleukin-6 Type Cytokines , 1998, The Journal of Biological Chemistry.
[158] T. Martin,et al. Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors , 1995, The Journal of experimental medicine.
[159] R. Landes,et al. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. , 2002, The Journal of clinical investigation.
[160] A. M. Parfitt,et al. Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of Osteoporosis , 2001 .
[161] C. Leu,et al. The integrin ligand echistatin prevents bone loss in ovariectomized mice and rats. , 1998, Endocrinology.
[162] D. Hewett‐Emmett,et al. Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[163] J. Delaissé,et al. Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones. , 1995, Journal of cell science.
[164] T. Thornhill,et al. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. , 1998, The American journal of pathology.
[165] S. Reddy,et al. Control of osteoclast differentiation. , 1998, Critical reviews in eukaryotic gene expression.
[166] R. Jilka,et al. Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARγ2 , 1999, Journal of cellular biochemistry.
[167] S. Manolagas. Editorial: Cell Number Versus Cell Vigor-What Really Matters to a Regenerating Skeleton? , 1999, Endocrinology.
[168] J. Wit,et al. The Role of Estrogen in the Control of Rat Osteocyte Apoptosis , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[169] B. Frenkel,et al. Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression. , 1997, Molecular endocrinology.
[170] M. Lieberherr,et al. Cell signaling and estrogens in female rat osteoblasts: A possible involvement of unconventional nonnuclear receptors , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[171] L. Bonewald,et al. Role of TGFβ in Bone Remodeling a , 1990 .
[172] E. Orwoll,et al. Quantitative Trait Loci Affecting Peak Bone Mineral Density in Mice , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[173] R. L. Cain,et al. Printed in U.S.A. Copyright © 2001 by The Endocrine Society Catabolic Effects of Continuous Human PTH (1–38) in Vivo Is Associated with Sustained Stimulation of RANKL and Inhibition of Osteoprotegerin and Gene-Associated Bone Formation , 2022 .
[174] T. Yoneda,et al. Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[175] A. Schulz,et al. Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis. , 2000, Human molecular genetics.
[176] T. Martin,et al. The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. , 1989, Endocrinology.
[177] G. Ciliberto,et al. Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion. , 1994, The EMBO journal.
[178] C. O’Brien,et al. STAT3 Activation in Stromal/Osteoblastic Cells Is Required for Induction of the Receptor Activator of NF-κB Ligand and Stimulation of Osteoclastogenesis by gp130-utilizing Cytokines or Interleukin-1 but Not 1,25-Dihydroxyvitamin D3 or Parathyroid Hormone* , 1999, The Journal of Biological Chemistry.
[179] M Horton,et al. The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure. , 1995, Journal of cell science.
[180] A. Kulkarni,et al. Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. , 1993, The American journal of pathology.
[181] Flemming Melsen,et al. Cancellous Bone Remodeling Occurs in Specialized Compartments Lined by Cells Expressing Osteoblastic Markers , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[182] E. Wagner,et al. HIF-1 mediated upregulation of VEGF and VEGF-R in systemic sclerosis (SSc): Imbalance with angiostatic factors suggests VEGF as a novel option for the treatment of ischemia in patients with SSc , 2002, Annals of the rheumatic diseases.
[183] E. Seeman,et al. Osteoporosis in Men , 1999, Osteoporosis International.
[184] K. Sewell. CALCITONIN. , 1965, Reactions Weekly.
[185] X. Liang,et al. A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats. , 2000, The Journal of clinical investigation.
[186] J. Simpkins,et al. Effects of 17β-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats , 1997, Experimental Brain Research.
[187] A. Ray,et al. On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion , 1990, Molecular and cellular biology.
[188] S. C. Lin,et al. Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. , 1997, The Journal of clinical investigation.
[189] D. Dempster,et al. Effect of pH on bone resorption by rat osteoclasts in vitro. , 1986, Endocrinology.
[190] E. Nishida,et al. Differentiation and Transforming Growth Factor-β Receptor Down-regulation by Collagen-α2β1 Integrin Interaction Is Mediated by Focal Adhesion Kinase and Its Downstream Signals in Murine Osteoblastic Cells* , 1997, The Journal of Biological Chemistry.
[191] T. Martin,et al. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. , 1999, Endocrine reviews.
[192] W. Wiktor-Jedrzejczak,et al. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[193] J. Milbrandt,et al. Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1. , 1998, The Journal of clinical investigation.
[194] G. Yancopoulos,et al. The alphas, betas, and kinases of cytokine receptor complexes , 1993, Cell.
[195] R. Jilka,et al. Essential Requirement of BMPs‐2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures from Adult Mice: Antagonism by Noggin , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[196] S. Mohan,et al. Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. , 1997, Endocrine reviews.
[197] H. Broxmeyer,et al. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. , 1995, The Journal of clinical investigation.
[198] A. Parfitt,et al. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. , 1996, The Journal of clinical investigation.
[199] G. Rodan. Osteopontin Overview , 1995, Annals of the New York Academy of Sciences.
[200] G. Passeri,et al. Interleukin-11: a new cytokine critical for osteoclast development. , 1994, The Journal of clinical investigation.
[201] Miikka Vikkula,et al. LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development , 2001, Cell.
[202] T. Chambers,et al. The sensitivity of isolated osteoclasts to morphological transformation by calcitonin. , 1983, The Journal of clinical endocrinology and metabolism.
[203] E. Bonucci,et al. Alkaline phosphatase positive precursors of adipocytes in the human bone marrow , 1988, British journal of haematology.
[204] P. Delmas,et al. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[205] F. Melsen,et al. Reconstruction of the resorptive site in iliac trabecular bone: a kinetic model for bone resorption in 20 normal individuals. , 1984, Metabolic bone disease & related research.
[206] R. Kimble,et al. Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period. , 1995, Endocrinology.
[207] K Yano,et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[208] R. Pietras,et al. Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells , 1977, Nature.
[209] C. Christiansen,et al. Mechanism of circadian variation in bone resorption. , 2002, Bone.
[210] B. Riggs,et al. Osteoclasts and transforming growth factor-beta: estrogen-mediated isoform-specific regulation of production. , 1996, Endocrinology.
[211] A. Economides,et al. Identification of mammalian noggin and its expression in the adult nervous system , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[212] Roodman Gd. Advances in bone biology : The osteoclast , 1996 .
[213] N. Franchimont,et al. Platelet-derived Growth Factor Induces Interleukin-6 Transcription in Osteoblasts through the Activator Protein-1 Complex and Activating Transcription Factor-2* , 1999, The Journal of Biological Chemistry.
[214] S. Cummings,et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. , 1995, The New England journal of medicine.
[215] C. Damsky,et al. Fibronectin is a survival factor for differentiated osteoblasts. , 1998, Journal of cell science.
[216] G. Greene,et al. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. , 1999, Molecular endocrinology.
[217] J. Compston,et al. Principles of Bone Biology , 1997 .
[218] P. Couttet,et al. Estradiol and raloxifene decrease the formation of multinucleate cells in human bone marrow cultures. , 2002, European cytokine network.
[219] R. Lindsay,et al. Anabolic actions of parathyroid hormone on bone. , 1993, Endocrine reviews.
[220] M. Pittenger,et al. Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.
[221] C. Lowik,et al. Colony stimulating factor‐1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone‐related protein , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[222] H. Broxmeyer,et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. , 1992, Science.
[223] J. Rungby,et al. Hormone Replacement Therapy Prevents Osteoclastic Hyperactivity: A Histomorphometric Study in Early Postmenopausal Women , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[224] K. Korach,et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. , 1994, The New England journal of medicine.
[225] T. Allen,et al. Pericyte differentiation. , 1995, Clinical orthopaedics and related research.
[226] L. Watson,et al. Studies in Osteopetrosis , 1965, Archives of disease in childhood.
[227] M C Farach-Carson,et al. Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption. , 1993, The Journal of biological chemistry.
[228] M. Revilla,et al. Salmon calcitonin reduces vertebral fracture rate in postmenopausal crush fracture syndrome. , 1992, Bone and mineral.
[229] F. Parhami,et al. Atherogenic Diet and Minimally Oxidized Low Density Lipoprotein Inhibit Osteogenic and Promote Adipogenic Differentiation of Marrow Stromal Cells , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[230] S. Mohan,et al. Bone growth factors. , 1991, Clinical orthopaedics and related research.
[231] M. Wiznerowicz,et al. Interleukin‐6‐Type Cytokines and Their Receptors for Gene Therapy of Melanoma a , 1995, Annals of the New York Academy of Sciences.
[232] J. Reeve,et al. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. , 1997, The Journal of clinical endocrinology and metabolism.
[233] A. Friedenstein,et al. Stromal stem cells: marrow-derived osteogenic precursors. , 1988, Ciba Foundation symposium.
[234] C C Glüer,et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. , 1999, JAMA.
[235] D. Chang,et al. Reduction in Transforming Growth Factor β Receptor I Expression and Transcription Factor CBFa1 on Bone Cells by Glucocorticoid* , 1998, The Journal of Biological Chemistry.
[236] T. Martin,et al. Hormonal Regulation of Osteoclast Function , 1998, Trends in Endocrinology & Metabolism.
[237] H. Broxmeyer,et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6 , 1992 .
[238] E. Canalis. Inhibitory actions of glucocorticoids on skeletal growth. Is local insulin-like growth factor I to blame? , 1998, Endocrinology.
[239] H. Frost,et al. Tetracycline-based study of bone dynamics in pycnodysostosis. , 1971, Clinical orthopaedics and related research.
[240] A. Schulz,et al. Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man , 2001, Cell.
[241] A. Parfitt. The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. , 1982, Metabolic bone disease & related research.
[242] B. Riggs,et al. Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women. , 1996, The Journal of clinical endocrinology and metabolism.
[243] R. Weinstein,et al. New Developments in the Pathogenesis and Treatment of Steroid‐Induced Osteoporosis , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[244] J. Steinfort,et al. Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[245] M. Karsdal,et al. Transforming Growth Factor-β-induced Osteoblast Elongation Regulates Osteoclastic Bone Resorption through a p38 Mitogen-activated Protein Kinase- and Matrix Metalloproteinase-dependent Pathway* , 2001, The Journal of Biological Chemistry.
[246] R. Turner,et al. Printed in U.S.A. Copyright © 1997 by The Endocrine Society The Effects of Programmed Administration of Human Parathyroid Hormone Fragment (1–34) on Bone Histomorphometry and Serum Chemistry in Rats* , 2022 .
[247] H. Weinstein,et al. Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis. , 1999, The Journal of clinical investigation.
[248] K. Becker,et al. Principles and Practice of Endocrinology and Metabolism , 1990 .
[249] B. Epker,et al. Suggested Sequential Mode of Control of Changes in Cell Behaviour in Adult Bone Remodelling , 1965, Nature.
[250] F. Ross,et al. Estrogen Decreases Osteoclast Formation by Down-regulating Receptor Activator of NF-κB Ligand (RANKL)-induced JNK Activation* , 2001, The Journal of Biological Chemistry.
[251] A. Parfitt,et al. Theoretical perspective: A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates , 1996 .
[252] E. Eriksen,et al. Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. , 1986, Endocrine reviews.
[253] J Dequeker,et al. Biochemistry of bone. , 1988, Bailliere's clinical rheumatology.
[254] R. Rizzoli,et al. TRANSGENIC MICE EXPRESSING SOLUBLE TUMOR NECROSIS FACTOR-RECEPTOR ARE PROTECTED AGAINST BONE LOSS CAUSED BY ESTROGEN DEFICIENCY , 1997 .
[255] W. Grzesik,et al. Bone matrix RGD glycoproteins: Immunolocalization and interaction with human primary osteoblastic bone cells in vitro , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[256] L. Melton,et al. Involutional osteoporosis. , 1986, The New England journal of medicine.
[257] J. Lewis,et al. Estrogen's bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells. , 1999, The Journal of clinical investigation.
[258] C. Rosen,et al. Growth Hormone, Insulin-like Growth Factors , 2001 .
[259] C. Ware,et al. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. , 1995, Development.
[260] A. Parfitt,et al. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. , 1998, The Journal of clinical investigation.
[261] P. Schiller,et al. Age‐Related Osteogenic Potential of Mesenchymal Stromal Stem Cells from Human Vertebral Bone Marrow , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[262] E. Canalis. Editorial: Inhibitory Actions of Glucocorticoids on Skeletal Growth. Is Local Insulin-Like Growth Factor I to Blame? , 1998, Endocrinology.
[263] R. Baron,et al. Murine bone marrow stromally derived BMS2 adipocytes support differentiation and function of osteoclast-like cells in vitro. , 1998, Endocrinology.
[264] W. Murphy,et al. Biochemical and radiologic improvement in Paget's disease of bone treated with alendronate: a randomized, placebo-controlled trial. , 1996, The American journal of medicine.
[265] G M Besser,et al. Serum cytokines in thyrotoxicosis. , 1999, The Journal of clinical endocrinology and metabolism.
[266] B. Gelb,et al. Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency , 1996, Science.
[267] T. Toth,et al. Prevention of estrogen deficiency-related bone loss with human parathyroid hormone-(1-34): a randomized controlled trial. , 1998, JAMA.
[268] T. Chambers,et al. Calcitonin alters behaviour of isolated osteoclasts , 1982, The Journal of pathology.
[269] T. Martin,et al. Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis. , 2002, The American journal of pathology.
[270] B. Katzenellenbogen,et al. Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[271] J. Compston,et al. Bone histomorphometry and structure in corticosteroid treated chronic active hepatitis. , 1988, Gut.
[272] M. Schena,et al. Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes , 1988 .
[273] F. Reinholt,et al. Chondroclasts and Osteoclasts in Bones of Young Rats: Comparison of Ultrastructural and Functional Features , 1998, Calcified Tissue International.
[274] Silvia Bernardini,et al. Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation , 2000, The Journal of cell biology.
[275] S. Manolagas. The Role of IL‐6 Type Cytokines and Their Receptors in Bonea a , 1998 .
[276] B. McEwen,et al. Estrogen actions in the central nervous system. , 1999, Endocrine reviews.
[277] P. Roberson,et al. Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption. , 1998, The Journal of clinical investigation.
[278] R. Jilka,et al. Cytokines, bone remodeling, and estrogen deficiency: a 1998 update. , 1998, Bone.
[279] M. Nuttall,et al. Human Trabecular Bone Cells Are Able to Express Both Osteoblastic and Adipocytic Phenotype: Implications for Osteopenic Disorders , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[280] S. Enerbäck,et al. The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. , 1991, The EMBO journal.
[281] L. Bonewald,et al. Latent Forms of Transforming Growth Factor-β (TGFβ) Derived from Bone Cultures: Identification of a Naturally Occurring 100-kDa Complex with Similarity to Recombinant Latent TGFβ , 1991 .
[282] R. Karas,et al. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. , 1999, The Journal of clinical investigation.
[283] T. Martin,et al. Therapeutic approaches to bone diseases. , 2000, Science.
[284] A. Hall,et al. G Proteins and Small GTPases: Distant Relatives Keep in Touch , 1998, Science.
[285] G. Marotti. The structure of bone tissues and the cellular control of their deposition. , 1996, Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia.
[286] H. Shibuya,et al. A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction. , 1999, Developmental biology.
[287] J. Gimble,et al. The function of adipocytes in the bone marrow stroma: an update. , 1996, Bone.
[288] N. Udagawa,et al. Interleukin‐6 and soluble interleukin‐6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast‐like cell formation , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[289] I. Reid,et al. Glucocorticoid effects on bone. , 1998, The Journal of clinical endocrinology and metabolism.
[290] H. Steller. Mechanisms and genes of cellular suicide , 1995, Science.
[291] D. Rao,et al. Effects of Ethnicity and Age or Menopause on Osteoblast Function, Bone Mineralization, and Osteoid Accumulation in Iliac Bone , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[292] P. Schlesinger,et al. Passive chloride permeability charge coupled to H(+)-ATPase of avian osteoclast ruffled membrane. , 1991, The American journal of physiology.
[293] G D Roodman,et al. Cell biology of the osteoclast. , 1999, Experimental Hematology.
[294] A. Galanos,et al. A Randomized Trial of Nasal Spray Salmon Calcitonin in Men With Idiopathic Osteoporosis: Effects on Bone Mineral Density and Bone Markers , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[295] M A Horton,et al. A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. , 1997, The Journal of clinical investigation.
[296] M. Horton,et al. Trafficking of matrix collagens through bone-resorbing osteoclasts. , 1997, Science.
[297] G. Roodman,et al. Advances in bone biology: the osteoclast. , 1996, Endocrine reviews.
[298] L. Mosekilde,et al. Ultrastructural investigations of bone resorptive cells in two types of autosomal dominant osteopetrosis. , 1993, Bone.
[299] B. Spiegelman,et al. Adipogenesis and Obesity: Rounding Out the Big Picture , 1996, Cell.
[300] N. Takahashi,et al. Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts. , 1996, Endocrinology.
[301] Thiennu H. Vu,et al. Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones , 2000, The Journal of cell biology.
[302] S. Nesbitt,et al. β1 integrins and osteoclast function: Involvement in collagen recognition and bone resorption , 1996 .
[303] A. Bilancio,et al. Non‐transcriptional action of oestradiol and progestin triggers DNA synthesis , 1999, The EMBO journal.
[304] D. Mcnulty,et al. Proteolytic Activity of Human Osteoclast Cathepsin K , 1996, The Journal of Biological Chemistry.
[305] G. Yancopoulos,et al. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. , 1994, The Journal of biological chemistry.
[306] J. Risteli,et al. Immunochemical characterization of assay for carboxyterminal telopeptide of human type I collagen: loss of antigenicity by treatment with cathepsin K. , 2000, Bone.
[307] S. Khosla,et al. Minireview: the OPG/RANKL/RANK system. , 2001, Endocrinology.
[308] S. Shany,et al. Interaction Between Estrogen and Vitamin D–Endocrine System: A Potential Addition to the Unitary Model of Osteoporosis , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[309] B. Spiegelman,et al. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[310] G. Marotti,et al. A quantitative evaluation of osteoblast-osteocyte relationships on growing endosteal surface of rabbit tibiae. , 1992, Bone.
[311] H. Genant,et al. Parathyroid hormone treatment can reverse corticosteroid-induced osteoporosis. Results of a randomized controlled clinical trial. , 1998, The Journal of clinical investigation.
[312] J. Bilezikian,et al. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. , 1998, The New England journal of medicine.
[313] Y. Koishihara,et al. Endogenous bone‐resorbing factors in estrogen deficiency: Cooperative effects of IL‐1 and IL‐6 , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[314] P. Goldhaber,et al. H+ stimulation of cell-mediated bone resorption in tissue culture. , 1987, The American journal of physiology.
[315] R. Dubose,et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function , 1997, Nature.
[316] W. O'Fallon,et al. Bone Density and Fracture Risk in Men , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[317] R. Baron,et al. Cellular kinetics of the bone remodeling sequence in the rat , 1982, The Anatomical record.
[318] R. Evans,et al. Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ , 1998, Cell.
[319] L. Lajtha. Stem cell concepts. , 1979, Nouvelle revue francaise d'hematologie.
[320] O. Verborgt,et al. Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[321] M Dioszegi,et al. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). , 2001, Human molecular genetics.
[322] G D Roodman,et al. Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone. , 1992, The Journal of clinical investigation.
[323] P. Roberson,et al. Printed in U.S.A. Copyright © 1997 by The Endocrine Society Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes , 2022 .
[324] M. Hafner,et al. Effects of estradiol-17 beta analogues on activation of estrogen response element regulated chloramphenicol acetyltransferase expression. , 1993, Biochemistry.
[325] Gabriele Bergers,et al. MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes , 1998, Cell.
[326] T. Bouwmeester,et al. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer , 1996, Nature.
[327] K. Satomura,et al. Circulating Skeletal Stem Cells , 2001, The Journal of cell biology.
[328] N. Athanasou,et al. Osteoclast differentiation from circulating mononuclear precursors in Paget's disease is hypersensitive to 1,25-dihydroxyvitamin D(3) and RANKL. , 2000, Bone.
[329] J. Chow,et al. Nitric oxide synthase expression in bone cells. , 1998, Bone.
[330] Nils Brünner,et al. Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[331] B. Gelb,et al. Determination of Bone Markers in Pycnodysostosis: Effects of Cathepsin K Deficiency on Bone Matrix Degradation , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[332] J. Parsons,et al. Identification and characterization of a novel cytoskeleton-associated pp60src substrate , 1991, Molecular and cellular biology.
[333] F. Ross,et al. Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. , 1999, The Journal of clinical investigation.
[334] R. Kitazawa,et al. Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. , 1994, The Journal of clinical investigation.
[335] P. W. Johnston,et al. Nitric oxide: A cytokine‐induced regulator of bone resorption , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[336] M. Lazar,et al. Peroxisome Proliferator Activated Receptor γ, CCAAT/ Enhancer-binding Protein α, and Cell Cycle Status Regulate the Commitment to Adipocyte Differentiation* , 1997, The Journal of Biological Chemistry.
[337] S. Morony,et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis , 1999, Nature.
[338] D. Lacey,et al. Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation , 1998, Cell.
[339] S. Rodan,et al. Sphingosine kinase mediates cyclic AMP suppression of apoptosis in rat periosteal cells. , 1998, Molecular pharmacology.
[340] M. Oursler,et al. Estrogen modulation of avian osteoclast lysosomal gene expression. , 1993, Endocrinology.
[341] H. Okamura,et al. Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. , 1997 .
[342] Subburaman Mohan,et al. Growth factors to stimulate bone formation , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[343] E. Canalis,et al. Skeletal growth factors. , 2000, Critical reviews in eukaryotic gene expression.
[344] John C. Lee,et al. Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL* , 1998, The Journal of Biological Chemistry.
[345] T. Martin,et al. Modulation of osteoclast differentiation. , 1992, Endocrine reviews.
[346] Harold M. Frost,et al. Bone remodeling and its relationship to metabolic bone diseases , 1973 .
[347] E. Salmon,et al. Positive feedback interactions between microtubule and actin dynamics during cell motility. , 1999, Current opinion in cell biology.
[348] T. Martin,et al. Receptors of Calciotropic Hormones , 1997, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[349] G. Rodan,et al. High Fatty Acid Content in Rabbit Serum Is Responsible for the Differentiation of Osteoblasts Into Adipocyte‐like Cells , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[350] B. Spiegelman,et al. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor , 1994, Cell.
[351] A. Parfitt. Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression. , 2002, Bone.
[352] Lynn Wei,et al. Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis. , 1997, The Journal of clinical investigation.
[353] P. Garnero,et al. Treatment of Postmenopausal Women with Osteoporosis or Low Bone Density with Raloxifene , 1999, Osteoporosis International.
[354] P. Astrup,et al. The acid-base metabolism. A new approach. , 1960, Lancet.
[355] S. Majumdar,et al. Insulin‐Like Growth Factor I Is Required for the Anabolic Actions of Parathyroid Hormone on Mouse Bone , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[356] S. Shibata,et al. An ultrastructural study of osteoclasts and chondroclasts in poorly calcified mandible induced by high doses of strontium diet to fetal mice. , 2001, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.
[357] B. Riggs,et al. Treatment of Established Postmenopausal Osteoporosis with Raloxifene: A Randomized Trial , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[358] F. Melsen,et al. Structural and histomorphometric studies of iliac crest trabecular and cortical bone in autosomal dominant osteopetrosis: a study of two radiological types. , 1989, Bone.
[359] J. Tobias,et al. Early effects of hormone replacement therapy on bone. , 1999, Bone.
[360] A. Villanueva,et al. Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[361] I. Kola,et al. Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[362] K. Hultenby,et al. Osteoclasts from mice deficient in tartrate-resistant acid phosphatase have altered ruffled borders and disturbed intracellular vesicular transport. , 2002, Experimental cell research.
[363] S. Manolagas. Cell number versus cell vigor--what really matters to a regenerating skeleton? , 1999, Endocrinology.
[364] G. Gundersen,et al. Rho Guanosine Triphosphatase Mediates the Selective Stabilization of Microtubules Induced by Lysophosphatidic Acid , 1998, The Journal of cell biology.
[365] J. Pike,et al. Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[366] P. Schlesinger,et al. Substrate Recognition by Osteoclast Precursors Induces C-src/Microtubule Association , 1997, The Journal of cell biology.
[367] T. Yoneda,et al. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[368] H. Gundersen,et al. Reconstruction of the formative site in iliac trabecular bone in 20 normal individuals employing a kinetic model for matrix and mineral apposition. , 1984, Metabolic bone disease & related research.
[369] T. Miyata,et al. Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles. , 1997, Journal of the American Society of Nephrology : JASN.
[370] H. Mankin,et al. Nontraumatic necrosis of bone (osteonecrosis). , 1992, The New England journal of medicine.
[371] A. Parfitt,et al. The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. , 1997, Endocrinology.
[372] L Berga,et al. Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study. , 1989, Experimental hematology.
[373] D B Burr,et al. Targeted and nontargeted remodeling. , 2002, Bone.
[374] D J Baylink,et al. Glucocorticoid-induced osteoporosis. , 1983, The New England journal of medicine.
[375] S. Manolagas,et al. Osteopontin expression by osteoclast and osteoblast progenitors in the murine bone marrow: demonstration of its requirement for osteoclastogenesis and its increase after ovariectomy. , 1997, Endocrinology.
[376] A. Parfitt. The mechanism of coupling: a role for the vasculature. , 2000, Bone.
[377] J. Darnell. STATs and gene regulation. , 1997, Science.
[378] Allan Bradley,et al. Increased bone formation in osteocalcin-deficient mice , 1996, Nature.
[379] B. Epker,et al. RESORPTION PRECEDES FORMATIVE ACTIVITY. , 1964, Surgical forum.
[380] Napoleone Ferrara,et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation , 1999, Nature Medicine.
[381] S. Houssami,et al. Calcitonin receptor isoforms in mouse and rat osteoclasts , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[382] K. Hruska,et al. Rho-A Is Critical for Osteoclast Podosome Organization, Motility, and Bone Resorption* , 2000, The Journal of Biological Chemistry.
[383] G. Howard,et al. Parathyroid hormone stimulates bone formation and resorption in organ culture: evidence for a coupling mechanism. , 1981, Proceedings of the National Academy of Sciences of the United States of America.
[384] C. Rosen,et al. Chapter 78 – Growth Hormone, Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis , 2001 .
[385] H. Varmus,et al. Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. , 1997, Genes & development.
[386] S. Mohan,et al. The insulin-like growth factor system and the coupling of formation to resorption. , 1995, Bone.
[387] Y. Sasai,et al. Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4 , 1996, Cell.