Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

[1]  P. Feig,et al.  Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension. , 2011, Journal of the American Society of Hypertension : JASH.

[2]  J. Tomlinson,et al.  11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes , 2010, Expert opinion on investigational drugs.

[3]  Jiandong Zhang,et al.  Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221). , 2010, Journal of medicinal chemistry.

[4]  J. Rosenstock,et al.  The 11-β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy , 2010, Diabetes Care.

[5]  N. Morton Obesity and corticosteroids: 11β-Hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease , 2010, Molecular and Cellular Endocrinology.

[6]  A. Fanjul,et al.  N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. , 2009, Bioorganic & medicinal chemistry letters.

[7]  N. Walker,et al.  Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors. , 2009, Bioorganic & medicinal chemistry letters.

[8]  Jiandong Zhang,et al.  Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. , 2008, Journal of medicinal chemistry.

[9]  Minghan Wang,et al.  Blockade of glucocorticoid excess at the tissue level: inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes. , 2008, Journal of medicinal chemistry.

[10]  R. Thieringer,et al.  Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. , 2008, Bioorganic & medicinal chemistry letters.

[11]  Akbar Nayeem,et al.  Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. , 2008, Bioorganic & medicinal chemistry letters.

[12]  B. Walker,et al.  Tissue Production of Cortisol by 11β‐Hydroxysteroid Dehydrogenase Type 1 and Metabolic Disease , 2006, Annals of the New York Academy of Sciences.

[13]  U. Oppermann Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases? , 2006, Endocrine, metabolic & immune disorders drug targets.