Effects of diet on exaggerated natriuresis in hypertension.

The effects of high and low salt diet on exaggerated natriuresis after volume expansion were examined in two groups of hypertensive patients, 6 with labile and 6 with fixed uncomplicated essential hypertension. Fixed hypertensives eliminated the administered salt-load faster than the labile hypertensives, and diet had no effect on the exaggerated natriuresis of both groups. No association was observed between plasma renin activity and natriuresis in both groups of patients. We conclude that, 1) diet did not affect the saline-induced natriuresis in hypertensive patients, 2) there was no apparent association between plasma renin activity and exaggerated natriuresis in hypertension, 3) other factors such as the capacitance system and vasopressin may play an important role in volume expansion natriuresis, especially in fixed hypertensives.

[1]  M. Manning,et al.  The Importance of Vasopressin in the Development and Maintenance of DOC‐Salt Hypertension in the Rat , 1979, Hypertension.

[2]  E. Frohlich,et al.  Hemodynamic and metabolic evidence of salt sensitivity in spontaneously hypertensive rats. , 1979, Kidney international.

[3]  T. A. Anderson,et al.  The effect of dietary sodium chloride on blood pressure, body fluids, electrolytes, renal function, and serum lipids of normotensive man. , 1976, The Journal of laboratory and clinical medicine.

[4]  R. Lindeman,et al.  Natriuresis and Carbohydrate-Induced Antinatriuresis in Fasted, Hydrated Hypertensives , 1975, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[5]  W. Jubiz,et al.  Hypertension in patients on maintenance hemodialysis: evaluation of peripheral renin activity and bilateral nephrectomy. , 1972, American Journal of the Medical Sciences.

[6]  W. Birkenhäger,et al.  Studies on the mechanism of hypernatriuresis in essential hypertension in relation to measurements of plasma renin concentration, body fluid compartments and renal function. , 1971, Clinical science.

[7]  J. W. Czaczkes,et al.  Natriuretic activity of a substance isolated from human urine during the excretion of a salt load. Comparison of hypertensive and normotensive subjects. , 1971, Nephron.

[8]  J. Laragh,et al.  The Role of Renin in the Exaggerated Natriuresis of Hypertension , 1970, Circulation.

[9]  P. Cannon,et al.  The Influence of Hypertonic Saline Infusions Upon the Fractional Reabsorption of Urate and Other Ions in Normal and Hypertensive Man , 1970, Circulation.

[10]  E. Haber,et al.  Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. , 1969, The Journal of clinical endocrinology and metabolism.

[11]  C. Hyman,et al.  Venous Distensibility in Essential Hypertension , 1969 .

[12]  V. Buckalew,et al.  Mechanism of exaggerated natriuresis in hypertensive man: impaired sodium transport in the loop of Henle. , 1969, The Journal of clinical investigation.

[13]  P. Cannon.  Effects of Five Per Cent Dextrose‐Water Infusions in Normal and Hypertensive Man: Evidence for Increased Proximal and Distal Tubular Sodium Rejection by Hypertensive Patients and Its Relation to Renal Hemodynamics , 1968, Circulation.

[14]  A. Aviram,et al.  Diuretic and natriuretic response to a salt load in hypertensive and pre-hypertensive subjects. , 1965, Nephron.

[15]  S. Papper,et al.  The response to the administration of an isotonic sodium chloride-lactate solution in patients with essential hypertension. , 1960, The Journal of clinical investigation.

[16]  B. F. Miller,et al.  Renal Excretion of Sodium in Arterial Hypertension , 1959, Circulation.

[17]  S. Hoobler,et al.  Sodium Chloride Excretion Following Salt Loading in Hypertensive Subjects , 1958, Circulation.

[18]  W. Goldring,et al.  Exaggerated natriuresis in essential hypertension. , 1958, The American journal of medicine.

[19]  S. Hoobler,et al.  Effect of an Intravenous Sodium Chloride Load on Renal Hemodynamics and Electrolyte Excretion in Essential Hypertension , 1958, Circulation.