Novel synthesis naringenin-benzyl piperazine derivatives prevent glioblastoma invasion by inhibiting the hypoxia-induced IL6/JAK2/STAT3 axis and activating caspase-dependent apoptosis.
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O. Doğanlar | Zeynep Banu Doğanlar | Ömer Zaim | Hafize Özcan | Mohamed M. Zreigh | Kardelen Kurtdere
[1] Zeng-hong Wu,et al. Prognostic value and immune relevancy of a combined autophagy-, apoptosis- and necrosis-related gene signature in glioblastoma , 2022, BMC cancer.
[2] Heung Kyu Lee,et al. Current Understanding of Hypoxia in Glioblastoma Multiforme and Its Response to Immunotherapy , 2022, Cancers.
[3] O. Doğanlar,et al. Prolonged sub-lethal exposure to galaxolide (HHCB) and tonalide (AHTN) promotes the metastatic potential of glioblastoma tumor spheroids. , 2021, Neurotoxicology.
[4] H. Daldrup-Link,et al. Glioblastoma Multiforme (GBM): An overview of current therapies and mechanisms of resistance. , 2021, Pharmacological research.
[5] A. Heimberger,et al. The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma , 2021, Cancers.
[6] Zhe-Shan Quan,et al. Piperazine skeleton in the structural modification of natural products: a review , 2021, Journal of enzyme inhibition and medicinal chemistry.
[7] Wajhul Qamar,et al. Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms , 2020, Plants.
[8] O. Doğanlar,et al. Chronic exposure of human glioblastoma tumors to low concentrations of a pesticide mixture induced multidrug resistance against chemotherapy agents. , 2020, Ecotoxicology and environmental safety.
[9] J. Grandis,et al. Targeting the JAK/STAT pathway in solid tumors , 2020, Journal of cancer metastasis and treatment.
[10] Emre Delen,et al. The Dose Dependent Effects of Ruxolitinib on the Invasion and Tumorigenesis in Gliomas Cells via Inhibition of Interferon Gamma-Depended JAK/STAT Signaling Pathway , 2020, Journal of Korean Neurosurgical Society.
[11] B. Kamińska,et al. STAT Signaling in Glioma Cells. , 2020, Advances in experimental medicine and biology.
[12] I. Kruk,et al. Preparation and in vitro antioxidant activity of some novel flavone analogues bearing piperazine moiety. , 2019, Bioorganic chemistry.
[13] K. Shokat,et al. Cooperative blockade of PKCα and JAK2 drives apoptosis in glioblastoma. , 2019, Cancer research.
[14] A. Alzahrani. PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside. , 2019, Seminars in cancer biology.
[15] K. Skelding,et al. Glioblastoma Multiforme: An Overview of Emerging Therapeutic Targets , 2019, Front. Oncol..
[16] Han-Seung Shin,et al. Sulfonylpiperazines based on a flavone as antioxidant and cytotoxic agents , 2019, Archiv der Pharmazie.
[17] H. Badali,et al. New potent antifungal triazole alcohols containing N-benzylpiperazine carbodithioate moiety: Synthesis, in vitro evaluation and in silico study. , 2019, Bioorganic chemistry.
[18] Shilong Zheng,et al. Nitrogen-containing derivatives of O-tetramethylquercetin: Synthesis and biological profiles in prostate cancer cell models. , 2019, Bioorganic chemistry.
[19] Emre Delen,et al. Inhibition of the invasion of human glioblastoma U87 cell line by ruxolitinib: a molecular player of miR-17 and miR-20a regulating JAK/STAT pathway. , 2019, Turkish neurosurgery.
[20] Jie Li,et al. admetSAR 2.0: web‐service for prediction and optimization of chemical ADMET properties , 2018, Bioinform..
[21] O. Doğanlar,et al. Synthesis, Cancer‐Selective Antiproliferative and Apoptotic Effects of Some (±)‐Naringenin Cycloaminoethyl Derivatives , 2018, Chemistry & biodiversity.
[22] A. Tiwari,et al. Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents. , 2018, European journal of medicinal chemistry.
[23] Ricardo J. Ferreira,et al. Optimizing the flavanone core toward new selective nitrogen-containing modulators of ABC transporters. , 2018, Future medicinal chemistry.
[24] Olivier Michielin,et al. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules , 2017, Scientific Reports.
[25] Tinghan Li,et al. Synthesis, evaluation and quantitative structure-activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents. , 2017, Bioorganic & medicinal chemistry letters.
[26] R. Heim,et al. Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. , 2016, Angewandte Chemie.
[27] J. Sung,et al. Chrysin-piperazine conjugates as antioxidant and anticancer agents. , 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[28] Tong Li,et al. A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway , 2016, Autophagy.
[29] J. Heiss,et al. B7-H4(B7x)–Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients , 2016, Clinical Cancer Research.
[30] Xiao Zhang,et al. Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells. , 2016, Experimental and therapeutic medicine.
[31] M. Akhter,et al. Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents. , 2015, European journal of medicinal chemistry.
[32] Xiuyu Wang,et al. Blocking the bFGF/STAT3 interaction through specific signaling pathways induces apoptosis in glioblastoma cells , 2014, Journal of Neuro-Oncology.
[33] R. Kunz,et al. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. , 2014, Journal of medicinal chemistry.
[34] Yong-min Zhang,et al. Synthesis and antitumor activity evaluation of chrysin derivatives. , 2014, European journal of medicinal chemistry.
[35] Timothy L. Foley,et al. 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl Transferase That Attenuates Secondary Metabolism and Thwarts Bacterial Growth , 2014, Journal of medicinal chemistry.
[36] F. Ciregia,et al. The activation of mitochondrial BK potassium channels contributes to the protective effects of naringenin against myocardial ischemia/reperfusion injury. , 2013, Biochemical pharmacology.
[37] B. Damania,et al. AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV , 2013, Front. Immun..
[38] B. Bao,et al. The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. , 2012, Biochimica et biophysica acta.
[39] Xiujie Wang,et al. Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications. , 2012, Experimental cell research.
[40] Jie Shen,et al. admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties , 2012, J. Chem. Inf. Model..
[41] M. Taha,et al. Synthesis and biological activity assays of some new N1-(flavon-7-yl)amidrazone derivatives and related congeners. , 2012, European journal of medicinal chemistry.
[42] N. Banik,et al. Survivin knockdown increased anti-cancer effects of (-)-epigallocatechin-3-gallate in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. , 2012, Experimental cell research.
[43] Wei-Chang Fu,et al. Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives. , 2012, Bioorganic & medicinal chemistry letters.
[44] J. Isaacs,et al. A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion , 2011, PloS one.
[45] Y. Tu,et al. Activation of JAK/STAT signal pathway predicts poor prognosis of patients with gliomas , 2011, Medical oncology.
[46] T. Tamiya,et al. Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma , 2011, European Journal of Nuclear Medicine and Molecular Imaging.
[47] Yong Yang,et al. Reactive oxygen species-mitochondria pathway involved in LYG-202-induced apoptosis in human hepatocellular carcinoma HepG(2) cells. , 2010, Cancer letters.
[48] B. Bandgar,et al. Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents. , 2010, Bioorganic & medicinal chemistry letters.
[49] H. Lou,et al. Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[50] D. Sakthisekaran,et al. Naringenin reduces tumor size and weight lost in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. , 2008, Nutrition research.
[51] D. Barreca,et al. Flavonoid composition of Citrus juices. , 2007, Molecules.
[52] A. Piersma,et al. (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture. , 2007, Toxicology and applied pharmacology.
[53] P. Rasoanaivo,et al. Synthesis and antimalarial evaluation of a series of piperazinyl flavones. , 2007, Bioorganic & medicinal chemistry letters.
[54] U. Murthy,et al. Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. , 2006, Bioorganic & medicinal chemistry letters.
[55] P. Lambin,et al. The hypoxic proteome is influenced by gene-specific changes in mRNA translation. , 2005, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[56] M. Ishikawa,et al. Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice. , 2005, Biological & pharmaceutical bulletin.
[57] Y. Patel,et al. Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation , 2004, Breast Cancer Research and Treatment.
[58] J. Marx. How Cells Endure Low Oxygen , 2004, Science.
[59] C. Gardana,et al. Polyphenol Pattern and Antioxidant Activity of Different Tomato Lines and Cultivars , 2003, Annals of Nutrition and Metabolism.
[60] P. Jones,et al. Hypoxia and lung branching morphogenesis. , 2003, Advances in experimental medicine and biology.
[61] Ferran Sánchez-Rabaneda,et al. Liquid chromatographic/electrospray ionization tandem mass spectrometric study of the phenolic composition of cocoa (Theobroma cacao). , 2003, Journal of mass spectrometry : JMS.
[62] L. Poellinger,et al. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[63] P. Ho,et al. Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. , 2000, Pharmaceutica acta Helvetiae.
[64] T. Nagem,et al. Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations. , 1999, Pharmacological research.
[65] M. Nair,et al. Antioxidant polyphenols from tart cherries (Prunus cerasus). , 1999, Journal of agricultural and food chemistry.
[66] G. Lewin,et al. Flavonoid-related modulators of multidrug resistance: synthesis, pharmacological activity, and structure-activity relationships. , 1999, Journal of medicinal chemistry.
[67] N Guthrie,et al. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. , 1996, Nutrition and cancer.
[68] R. K. Bhattacharya,et al. Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine. , 1989, Carcinogenesis.