Analogs of a potent maxi-K potassium channel opener with an improved inhibitory profile toward cytochrome P450 isozymes.

[1]  V. Gribkoff,et al.  3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction. , 2004, Bioorganic & medicinal chemistry letters.

[2]  Y. Ukai,et al.  A novel pyrrole derivative, NS‐8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity , 2003, BJU international.

[3]  V. Gribkoff,et al.  4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction. , 2003, Journal of medicinal chemistry.

[4]  J. Morrow,et al.  Therapeutic potential of potassium channel modulators for CNS disorders , 2003 .

[5]  V. Gribkoff,et al.  The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection. , 2002, Bioorganic & medicinal chemistry letters.

[6]  V. Gribkoff,et al.  Maxi-K Potassium Channels: Form, Function, and Modulation of a Class of Endogenous Regulators of Intracellular Calcium , 2001, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[7]  J. Sullivan,et al.  Potassium channels: molecular defects, diseases, and therapeutic opportunities. , 2000, Pharmacological reviews.

[8]  Jeffrey P. Jones,et al.  A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions. , 2000, Journal of medicinal chemistry.

[9]  V. Gribkoff,et al.  Effects of channel modulators on cloned large-conductance calcium-activated potassium channels. , 1996, Molecular pharmacology.

[10]  D. Mansuy,et al.  The substrate binding site of human liver cytochrome P450 2C9: an approach using designed tienilic acid derivatives and molecular modeling. , 1995, Biochemistry.

[11]  F. Guengerich,et al.  Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples. , 1991, The Journal of pharmacology and experimental therapeutics.

[12]  J. Musser,et al.  N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure. , 1990, Journal of medicinal chemistry.

[13]  Z. Rappoport The chemistry of the cyano group , 1970 .

[14]  W. Rost,et al.  Aryloxyacetamidines of medicinal interest. , 1969, Journal of pharmaceutical sciences.