Functional connectivity in an fMRI working memory task in high-functioning autism

An fMRI study was used to measure the brain activation of a group of adults with high-functioning autism compared to a Full Scale and Verbal IQ and age-matched control group during an n-back working memory task with letters. The behavioral results showed comparable performance, but the fMRI results suggested that the normal controls might use verbal codes to perform the task, while the adults with autism might use visual codes. The control group demonstrated more activation in the left than the right parietal regions, whereas the autism group showed more right lateralized activation in the prefrontal and parietal regions. The autism group also had more activation than the control group in the posterior regions including inferior temporal and occipital regions. The analysis of functional connectivity yielded similar patterns for the two groups with different hemispheric correlations. The temporal profile of the activity in the prefrontal regions was more correlated with the left parietal regions for the control group, whereas it was more correlated with the right parietal regions for the autism group.

[1]  U. Frith,et al.  A new look at language and communication in autism. , 1989, The British journal of disorders of communication.

[2]  Edward T. Bullmore,et al.  Cerebral correlates of preserved cognitive skills in , 1999 .

[3]  R. Müller,et al.  Brain Mapping of Language and Auditory Perception in High-Functioning Autistic Adults: A PET Study , 1999, Journal of autism and developmental disorders.

[4]  S. Baron-Cohen,et al.  Superior visual search in autism. , 2001, Journal of experimental psychology. Human perception and performance.

[5]  D. Tank,et al.  Brain magnetic resonance imaging with contrast dependent on blood oxygenation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[6]  N. Minshew,et al.  Neocortical system abnormalities in autism: An fMRI study of spatial working memory , 2002, Neurology.

[7]  U. Frith,et al.  An islet of ability in autistic children: a research note. , 1983, Journal of child psychology and psychiatry, and allied disciplines.

[8]  A. Galaburda,et al.  Human Cerebral Cortex: Localization, Parcellation, and Morphometry with Magnetic Resonance Imaging , 1992, Journal of Cognitive Neuroscience.

[9]  C. Genovese,et al.  Functional Imaging Analysis Software — Computational Olio , 1996 .

[10]  L. Mottron,et al.  A study of memory functioning in individuals with autism. , 2001, Journal of child psychology and psychiatry, and allied disciplines.

[11]  Michael I. Posner,et al.  Abstraction and The Process of Recognition , 1970 .

[12]  N. Minshew,et al.  Neuropsychologic functioning in autism: Profile of a complex information processing disorder , 1997, Journal of the International Neuropsychological Society.

[13]  M. Just,et al.  Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. , 2004, Brain : a journal of neurology.

[14]  Gerald Goldstein,et al.  Impaired memory for faces and social scenes in autism: clinical implications of memory dysfunction. , 2005, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[15]  U. Frith,et al.  Why do autistic individuals show superior performance on the block design task? , 1993, Journal of child psychology and psychiatry, and allied disciplines.

[16]  Karl J. Friston,et al.  Functional Connectivity: The Principal-Component Analysis of Large (PET) Data Sets , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[17]  M. Mesulam,et al.  From sensation to cognition. , 1998, Brain : a journal of neurology.

[18]  Satrajit S. Ghosh,et al.  Region of interest based analysis of functional imaging data , 2003, NeuroImage.

[19]  R. Turner,et al.  Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[20]  A. Couteur,et al.  Autism diagnostic interview: A standardized investigator-based instrument , 1989, Journal of autism and developmental disorders.

[21]  Jonathan D. Cohen,et al.  Working Memory for Letters, Shapes, and Locations: fMRI Evidence against Stimulus-Based Regional Organization in Human Prefrontal Cortex , 2000, NeuroImage.

[22]  C. Frith,et al.  Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. , 2002, Brain : a journal of neurology.

[23]  David L. Strayer,et al.  Executive function abilities in autism and Tourette syndrome: an information processing approach. , 1994, Journal of child psychology and psychiatry, and allied disciplines.

[24]  J Swettenham,et al.  Children with autism show local precedence in a divided attention task and global precedence in a selective attention task. , 1999, Journal of child psychology and psychiatry, and allied disciplines.

[25]  B. Postle,et al.  Maintenance versus Manipulation of Information Held in Working Memory: An Event-Related fMRI Study , 1999, Brain and Cognition.

[26]  M. Petrides,et al.  Functional organization of spatial and nonspatial working memory processing within the human lateral frontal cortex. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[27]  E. Ziegel,et al.  Proceedings in Computational Statistics , 1998 .

[28]  S. Baron-Cohen,et al.  Enhanced visual search for a conjunctive target in autism: a research note. , 1998, Journal of child psychology and psychiatry, and allied disciplines.

[29]  Edward E. Smith,et al.  A Parametric Study of Prefrontal Cortex Involvement in Human Working Memory , 1996, NeuroImage.

[30]  C. Genovese,et al.  Statistical Issues in fMRI for Brain Imaging , 2001 .

[31]  R. Cabeza,et al.  Handbook of functional neuroimaging of cognition , 2001 .

[33]  F. Volkmar,et al.  Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. , 2000, Archives of general psychiatry.

[34]  J. Jonides,et al.  Storage and executive processes in the frontal lobes. , 1999, Science.

[35]  B. Postle,et al.  “ What ” — Then — “ Where ” in Visual Working Memory : An Event-Related fMRI Study , 2000 .

[36]  S. Baron-Cohen,et al.  Enhanced discrimination of novel, highly similar stimuli by adults with autism during a perceptual learning task. , 1998, Journal of child psychology and psychiatry, and allied disciplines.

[37]  Marcel Adam Just,et al.  High Field Functional MRI in Humans: Applications to Cognitive Function , 1996 .

[38]  M. Just,et al.  Mental rotation of objects retrieved from memory: a functional MRI study of spatial processing. , 2001, Journal of experimental psychology. General.

[39]  August B. Hollingshead,et al.  Two Factor Index of Social Position , 1957 .

[40]  B. Pennington,et al.  Intact and impaired memory functions in autism. , 1996, Child development.

[41]  A. Couteur,et al.  Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders , 1994, Journal of autism and developmental disorders.

[42]  E T Bullmore,et al.  Cerebral correlates of preserved cognitive skills in autism: a functional MRI study of embedded figures task performance. , 1999, Brain : a journal of neurology.

[43]  M M Mesulam,et al.  Large‐scale neurocognitive networks and distributed processing for attention, language, and memory , 1990, Annals of neurology.

[44]  H. Critchley,et al.  The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions. , 2000, Brain : a journal of neurology.

[45]  David L. Strayer,et al.  Further Evidence of Intact Working Memory in Autism , 2001, Journal of autism and developmental disorders.

[46]  R. Reitan.  Ward Halstead's contributions to neuropsychology and the Halstead-Reitan Neuropsychological Test Battery. , 1994, Journal of clinical psychology.

[47]  Elisabeth L Hill,et al.  Understanding autism: insights from mind and brain. , 2003, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[48]  A. Anderson,et al.  An fMRI study of stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems , 1999, Biological Psychiatry.

[49]  Mark D'Esposito,et al.  Functional Neuroimaging of Working Memory , 2001 .

[50]  N. Minshew.  Brief report: Brain mechanisms in autism: Functional and structural abnormalities , 1996, Journal of autism and developmental disorders.

[51]  Nathalie Boddaert,et al.  Functional neuroimaging and childhood autism , 2001, Pediatric Radiology.

[52]  N. Minshew,et al.  Wechsler IQ profiles in diagnosis of high-functioning autism , 1996, Journal of autism and developmental disorders.

[53]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[54]  R. S. Hinks,et al.  Time course EPI of human brain function during task activation , 1992, Magnetic resonance in medicine.

[55]  Leslie G. Ungerleider,et al.  ‘What’ and ‘where’ in the human brain , 1994, Current Opinion in Neurobiology.

[56]  E. Courchesne,et al.  Face processing occurs outside the fusiform 'face area' in autism: evidence from functional MRI. , 2001, Brain : a journal of neurology.

[57]  M. Bauman,et al.  The Functional Neuroanatomy of Social Behavior , 2001 .

[58]  Jordan Grafman,et al.  Handbook of Neuropsychology , 1991 .

[59]  A Parving,et al.  Potential Language and Attentional Networks Revealed through Factor Analysis of rCBF Data Measured with SPECT , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[60]  Catherine Lord,et al.  Autism Spectrum Disorders , 2000, Neuron.

[61]  E E Smith,et al.  Components of verbal working memory: evidence from neuroimaging. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[62]  F. Gonzalez-Lima,et al.  Structural equation modeling and its application to network analysis in functional brain imaging , 1994 .

[63]  J. Russell,et al.  Working memory in children with autism and with moderate learning difficulties. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[64]  Patricia A Carpenter,et al.  Verbal and Spatial Working Memory in Autism , 2005, Journal of autism and developmental disorders.

[65]  N. Makris,et al.  MRI-Based Topographic Parcellation of Human Neocortex: An Anatomically Specified Method with Estimate of Reliability , 1996, Journal of Cognitive Neuroscience.

[66]  R. Henson,et al.  Frontal lobes and human memory: insights from functional neuroimaging. , 2001, Brain : a journal of neurology.