Protective Effect of Purinergic Agonist AtpΓS against Acute Lung Injury

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are major causes of acute respiratory failure associated with high morbidity and mortality. Although ALI/ARDS pathogenesis is ...

[1]  F. Härtel,et al.  Accumulation of extracellular ATP protects against acute reperfusion injury in rat heart endothelial cells. , 2006, Cardiovascular research.

[2]  J. Garcia,et al.  Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and cortactin. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[3]  Aftab Ahmad,et al.  Purinergic signaling and kinase activation for survival in pulmonary oxidative stress and disease. , 2006, Free radical biology & medicine.

[4]  M. Bours,et al.  Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. , 2006, Pharmacology & therapeutics.

[5]  R. Boucher,et al.  Increased susceptibility of purinergic receptor-deficient mice to lung infection with Pseudomonas aeruginosa. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[6]  S. P. Srinivas,et al.  Extracellular ATP opposes thrombin-induced myosin light chain phosphorylation and loss of barrier integrity in corneal endothelial cells. , 2005, Experimental eye research.

[7]  A. Verin,et al.  Signaling Pathways Involved in Adenosine Triphosphate-Induced Endothelial Cell Barrier Enhancement , 2005, Circulation research.

[8]  S. Robson,et al.  Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation. , 2005, Seminars in thrombosis and hemostasis.

[9]  H. Rabb,et al.  Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. , 2004, American journal of respiratory and critical care medicine.

[10]  R. E. Bucheimer,et al.  Purinergic regulation of epithelial transport , 2004, The Journal of physiology.

[11]  S. Matalon,et al.  Nucleotide-mediated inhibition of alveolar fluid clearance in BALB/c mice after respiratory syncytial virus infection. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[12]  F. Hirche,et al.  ATP antagonism of thrombin-induced endothelial barrier permeability. , 2003, Cardiovascular research.

[13]  J. Leipziger.  Control of epithelial transport via luminal P2 receptors. , 2003, American journal of physiology. Renal physiology.

[14]  I. Novak.  ATP as a signaling molecule: the exocrine focus. , 2003, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[15]  D. Kellerman,et al.  Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease. , 2002, Advanced drug delivery reviews.

[16]  C. Sartori,et al.  Alveolar epithelial fluid transport in acute lung injury: new insights , 2002, European Respiratory Journal.

[17]  E. Schwiebert,et al.  Extracellular ATP signaling and P2X nucleotide receptors in monolayers of primary human vascular endothelial cells. , 2002, American journal of physiology. Cell physiology.

[18]  F. Di Virgilio,et al.  Nucleotide receptors: an emerging family of regulatory molecules in blood cells. , 2001, Blood.

[19]  P. Hirth,et al.  Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. , 2000, The Journal of clinical investigation.

[20]  C. Szabó,et al.  ATP suppression of interleukin‐12 and tumour necrosis factor‐α release from macrophages , 2000 .

[21]  P. Dagnelie,et al.  Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. , 2000, Journal of the National Cancer Institute.

[22]  P. Vandenabeele,et al.  Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. , 1999, The Journal of clinical investigation.

[23]  Deniz Gündüz,et al.  ATP reduces macromolecule permeability of endothelial monolayers despite increasing [Ca2+]i. , 1999, American journal of physiology. Heart and circulatory physiology.

[24]  P. Dagnelie,et al.  Adenosine Triphosphate , 2012, Drugs.

[25]  C. Plata-salamán.  Cytokine-induced anorexia. Behavioral, cellular, and molecular mechanisms. , 1998, Annals of the New York Academy of Sciences.

[26]  G Burnstock,et al.  Receptors for purines and pyrimidines. , 1998, Pharmacological reviews.

[27]  G. Burnstock,et al.  Increased release of ATP from endothelial cells during acute inflammation , 1998, Inflammation Research.

[28]  A. Verin,et al.  Mechanisms of ionomycin-induced endothelial cell barrier dysfunction. , 1997, The American journal of physiology.

[29]  W. Kuebler,et al.  Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. , 1996, International journal of microcirculation, clinical and experimental.

[30]  A. Malik,et al.  Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[31]  J. Pearson,et al.  Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides , 1979, Nature.