Some test statistics for use in multistate survival analysis

SUMMARY Some current nonparametric methods related to the log rank test are extended to cover ordered categories of response, e.g. response, no change, progression, and to incorporate information on duration of response. As an example, data from a protocol for the treatment of advanced breast cancer are analysed. The powers of several tests for this special case of multistate survival data are compared by Monte Carlo simulation for both small and moderate samples from exponential and Weibull distributions.