Chemical Characterization of Magnolia Biondii (Flos Magnoliae, Xin Yi)

Samples of Magnolia biondii buds (Xin Yi, Flos Magnoliae) from different sources were subjected to phytochemical analysis and compared to samples of M. denudata and M. liliiflora. Among the compounds found in the flower buds of M. biondii were eight tetrahydrofurofuran lignans as well as the sesquiterpene lactone parthenolide and the sesquiterpene alcohol oplodiol. A rapid TLC-method for the identification of plant material from M. biondii and its distinction from M. liliiflora was developed. Structure elucidation was carried out by means of NMR (1- and 2-D) and LC-MS.

[1]  A. Pavirani,et al.  Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector , 2001, Gene Therapy.

[2]  Geoffrey D. Brown,et al.  Germacranolides from Artemisia myriantha and their conformation. , 2002, Phytochemistry.

[3]  M. Heinrich,et al.  Natural Products and their Role as Inhibitors of the Pro-Inflammatory Transcription Factor NF-κB , 2004, Phytochemistry Reviews.

[4]  M. Iwu,et al.  Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata. , 1999, Phytochemistry.

[5]  James F. Smith.  Phylogenetics of seed plants : An analysis of nucleotide sequences from the plastid gene rbcL , 1993 .

[6]  Professor Dr. Weici Tang,et al.  Chinese Drugs of Plant Origin , 1992, Springer Berlin Heidelberg.

[7]  J. Lee,et al.  Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii. , 1998, Archives of pharmacal research.

[8]  M. Ishikawa,et al.  Studies on sesquiterpenoids. Part XV. Structure and absolute configuration of oplodiol, a new sesquiterpene alcohol from Oplopanax japonicus(Nakai) Nakai , 1967 .

[9]  R. Ward,et al.  Revised structures for pluviatilol, methyl pluviatilol and xanthoxylol : General methods for the assignment of stereochemistry to 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane lignans , 1976 .

[10]  O. Hensens,et al.  Lignans with platelet activating factor antagonist activity from Magnolia biondii , 1987 .

[11]  H. Kameoka,et al.  Biotransformation of lignans: a specific microbial oxidation of (+)-eudesmin and (+)-magnolin by Aspergillus niger , 1993 .

[12]  T. Hofmann,et al.  The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex , 1999, The Journal of Immunology.

[13]  Kazuo Itô,et al.  Hydroperoxysesquiterpene and lignan constituents of Magnolia kobus , 1982 .

[14]  Jung Joon Lee,et al.  Sesquiterpene components from the flower buds ofMagnolia fargesii , 1997, Archives of pharmacal research.

[15]  G. Fan,et al.  Isolation and purification of lignans from Magnolia biondii Pamp by isocratic reversed-phase two-dimensional liquid chromatography following microwave-assisted extraction. , 2007, Journal of separation science.

[16]  Yu-liang Ma,et al.  A neolignan and lignans from Magnolia biondii , 1996 .

[17]  R. Gutell,et al.  Phylogenetic Analyses of Basal Angiosperms Based on Nine Plastid, Mitochondrial, and Nuclear Genes , 2005, International Journal of Plant Sciences.

[18]  Jongsung Lee,et al.  Isolation and identification of inhibitory compounds on TNF-α production fromMagnolia fargesii , 1998 .

[19]  M. Treiber,et al.  The anti‐inflammatory sesquiterpene lactone parthenolide suppresses IL‐4 gene expression in peripheral blood T cells , 2002, European journal of immunology.

[20]  H. Greger,et al.  New unsymmetrically substituted tetrahydrofurofuran lignans from artemisia absinthium: Assignment of the relative stereochemistry by lanthanide induced chemical shifts , 1980 .

[21]  R. Ward,et al.  Revised structures for epiaschantin and epimagnolin , 1977 .

[22]  T. Kaptchuk,et al.  Chinese Herbal Medicine: Materia Medica , 1986 .

[23]  J. E. Warnick,et al.  Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot , 2004, Pharmacology Biochemistry and Behavior.

[24]  K. Ohya,et al.  Studies on constituents of medicinal plants. XXII. Constituents of Schizandra nigra Max. , 1975, Chemical and pharmaceutical bulletin.

[25]  M. Chase,et al.  A COMBINED CLADISTIC ANALYSIS OF ANGIOSPERMS USING RBCL AND NON-MOLECULAR DATA SETS , 1998 .

[26]  H. Kakisawa,et al.  Lignans in flower buds of Magnolia fargesii , 1972 .

[27]  D. Guo,et al.  Two New Dibenzylbutyrolactone Type Lignans from the Stems of Kadsura heteroclita , 2006 .