Current Control and Future Risk in Asthma Management

Despite international and national guidelines, poor asthma control remains an issue. Asthma exacerbations are costly to both the individual, and the healthcare provider. Improvements in our understanding of the therapeutic benefit of asthma therapies suggest that, in general, while long-acting bronchodilator therapy improves asthma symptoms, the anti-inflammatory activity of inhaled corticosteroids reduces acute asthma exacerbations. Studies have explored factors which could be predictive of exacerbations. A history of previous exacerbations, poor asthma control, poor inhaler technique, a history of lower respiratory tract infections, poor adherence to medication, the presence of allergic rhinitis, gastro-oesophageal reflux disease, psychological dysfunction, smoking and obesity have all been implicated as having a predictive role in the future risk of asthma exacerbation. Here we review the current literature and discuss this in the context of primary care management of asthma.

[1]  G. Hibbert Demonstration and Treatment of Hyperventilation Causing Asthma , 1988, British Journal of Psychiatry.

[2]  R. Pauwels,et al.  GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION , 1996 .

[3]  Third Expert Panel on theDiagnosis,et al.  Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma , 1997 .

[4]  A. Zwinderman,et al.  Psychopathology in patients with severe asthma is associated with increased health care utilization. , 2001, American journal of respiratory and critical care medicine.

[5]  E. Bel,et al.  Similar psychological characteristics in mild and severe asthma. , 2001, Journal of psychosomatic research.

[6]  L. Rimington,et al.  Relationship between anxiety, depression, and morbidity in adult asthma patients , 2001, Thorax.

[7]  R. Pauwels,et al.  Low-dose inhaled corticosteroids and the prevention of death from asthma. , 2000, The New England journal of medicine.

[8]  Brigit VanGraafeiland,et al.  National Asthma Education and Prevention Program. , 2002, The Nurse practitioner.

[9]  P. Cauwenberge Allergic Rhinitis and its Impact on Asthma (ARIA) , 2002 .

[10]  S. Suissa,et al.  Regular use of inhaled corticosteroids and the long term prevention of hospitalisation for asthma , 2002, Thorax.

[11]  J. Bousquet,et al.  Allergic Rhinitis and its Impact on Asthma (ARIA) , 2003 .

[12]  S. Durham,et al.  Systematic assessment of difficult-to-treat asthma , 2003, European Respiratory Journal.

[13]  S. Chinn Obesity and Asthma: Evidence For and Against a Causal Relation , 2003, The Journal of asthma : official journal of the Association for the Care of Asthma.

[14]  C. Camargo,et al.  The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization. , 2003, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[15]  Philip Marcus,et al.  Development of the asthma control test: a survey for assessing asthma control. , 2004, The Journal of allergy and clinical immunology.

[16]  Charles A. Johnson,et al.  Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma. , 2004, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[17]  E. Ford Current reviews of allergy and clinical immunology , 2005 .

[18]  D. Price,et al.  Asthma-Related Health Care Resource Use Among Asthmatic Children With and Without Concomitant Allergic Rhinitis , 2005, Pediatrics.

[19]  C. Lemière,et al.  Are psychiatric disorders associated with worse asthma control and quality of life in asthma patients? , 2005, Respiratory medicine.

[20]  M. Abramson,et al.  Interactions Between Psychosocial Problems and Management of Asthma: Who Is at Risk of Dying? , 2005, The Journal of asthma : official journal of the Association for the Care of Asthma.

[21]  D. Price,et al.  Effect of a concomitant diagnosis of allergic rhinitis on asthma‐related health care use by adults , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[22]  Klas Svensson,et al.  Measurement properties and interpretation of three shortened versions of the asthma control questionnaire. , 2005, Respiratory medicine.

[23]  L. Markson,et al.  Using an asthma control questionnaire and administrative data to predict health-care utilization. , 2006, Chest.

[24]  B. Ditto,et al.  Higher BMI is associated with worse asthma control and quality of life but not asthma severity. , 2006, Respiratory medicine.

[25]  D. Price,et al.  ABS74: Large variations in asthma control between UK general practices participating in the asthma control, concordance and tolerance (ACCT) Initiative , 2006 .

[26]  Mike Thomas,et al.  High-dose inhaled corticosteroids and add-on therapy use in adults with asthma in the UK in 2003: an observational study. , 2006, Primary Care Respiratory Journal.

[27]  E. Cook,et al.  Determinants of future long-term asthma control. , 2006, The Journal of allergy and clinical immunology.

[28]  W. Busse,et al.  Determinants of response to fluticasone propionate and salmeterol/fluticasone propionate combination in the Gaining Optimal Asthma controL study. , 2007, The Journal of allergy and clinical immunology.

[29]  B. Dahme,et al.  Association of depression and anxiety with health care use and quality of life in asthma patients. , 2007, Respiratory medicine.

[30]  G. Giles,et al.  Childhood adiposity predicts adult-onset current asthma in females: a 25-yr prospective study , 2007, European Respiratory Journal.

[31]  H. El‐Serag,et al.  The association between gastro-oesophageal reflux disease and asthma: a systematic review , 2007, Gut.

[32]  M. Gould,et al.  Asthma control, severity, and quality of life: quantifying the effect of uncontrolled disease. , 2007, The Journal of allergy and clinical immunology.

[33]  Sally E Wenzel,et al.  Recent asthma exacerbations: a key predictor of future exacerbations. , 2007, Respiratory medicine.

[34]  S. Weiss,et al.  Association of control and risk of severe asthma‐related events in severe or difficult‐to‐treat asthma patients , 2007, Allergy.

[35]  N. Wareham,et al.  Psychosocial factors and incident asthma hospital admissions in the EPIC‐Norfolk cohort study , 2007, Allergy.

[36]  Jonathan D. Campbell,et al.  Comparison of guideline-based control definitions and associations with outcomes in severe or difficult-to-treat asthma. , 2008, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[37]  D. Price,et al.  Impact of comorbidities on asthma , 2008, Expert review of clinical immunology.

[38]  P. J. Barnes,et al.  Global strategy for asthma management and prevention: GINA executive summary , 2008, European Respiratory Journal.

[39]  G. Viegi,et al.  Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 * , 2008, Allergy.

[40]  J. Lammers,et al.  Extent of uncontrolled disease and associated medical costs in severe asthma--a PHARMO study. , 2008, Current medical research and opinion.

[41]  W. Busse,et al.  Stability of asthma control with regular treatment: an analysis of the Gaining Optimal Asthma controL (GOAL) study , 2008, Allergy.

[42]  Martyn R Partridge,et al.  British Guideline on the Management of Asthma , 2008, Thorax.

[43]  B. Yawn,et al.  Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update , 2008 .

[44]  I. Pavord,et al.  A new perspective on concepts of asthma severity and control , 2008, European Respiratory Journal.

[45]  E. Bleecker,et al.  Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. , 2009, The Journal of allergy and clinical immunology.

[46]  I. Pavord,et al.  An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. , 2009, American journal of respiratory and critical care medicine.

[47]  S. Szefler,et al.  Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma. , 2009, The Journal of allergy and clinical immunology.

[48]  S. Weiss,et al.  Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to-treat asthma. , 2009, Respiratory medicine.

[49]  D. Price,et al.  The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control. , 2009, Primary care respiratory journal : journal of the General Practice Airways Group.

[50]  M. Rottem [Allergic rhinitis and its impact on asthma]. , 2010, Harefuah.

[51]  Richard J Martin,et al.  Update on Infection and Antibiotics in Asthma , 2010, Current allergy and asthma reports.

[52]  D. Price,et al.  Observational study comparing intranasal mometasone furoate with oral antihistamines for rhinitis and asthma. , 2010, Primary care respiratory journal : journal of the General Practice Airways Group.

[53]  J. Stephenson,et al.  Subacute lack of asthma control as a predictor of subsequent acute asthma exacerbation in a managed care population. , 2010, The American journal of managed care.

[54]  E. Bleecker,et al.  Subacute Lack of Asthma Control and Acute Asthma Exacerbation History as Predictors of Subsequent Acute Asthma Exacerbations: Evidence From Managed Care Data , 2010, The Journal of asthma : official journal of the Association for the Care of Asthma.

[55]  D. Price,et al.  Prescribing practices and asthma control with hydrofluoroalkane-beclomethasone and fluticasone: a real-world observational study. , 2010, The Journal of allergy and clinical immunology.

[56]  Christine Jenkins,et al.  Overall asthma control: the relationship between current control and future risk. , 2010, The Journal of allergy and clinical immunology.

[57]  P. Demoly,et al.  Update on asthma control in five European countries: results of a 2008 survey , 2010, European Respiratory Review.

[58]  J. Haughney,et al.  Inhaler devices for asthma: a call for action in a neglected field , 2011, European Respiratory Journal.

[59]  G. Wong,et al.  Relationship between asthma control status, the Asthma Control Test™ and urgent health‐care utilization in Asia , 2011, Respirology.

[60]  A. Souza-Machado,et al.  Obesity and Poor Asthma Control in Patients with Severe Asthma , 2011, The Journal of asthma : official journal of the Association for the Care of Asthma.

[61]  P. Jhingran,et al.  Asthma That Is Not Well-Controlled Is Associated with Increased Healthcare Utilization and Decreased Quality of Life , 2011, The Journal of asthma : official journal of the Association for the Care of Asthma.

[62]  M. Zvolensky,et al.  The Role of Anxiety Sensitivity in terms of Asthma Control: A Pilot Test among Young Adult Asthmatics , 2011, Journal of health psychology.

[63]  Marco Lodi,et al.  Inhaler mishandling remains common in real life and is associated with reduced disease control. , 2011, Respiratory medicine.