论文信息 - A case of anaphylactic reaction to praziquantel treatment.

A case of anaphylactic reaction to praziquantel treatment.

A 35-year-old Chinese man was administered praziquantel for clonorchiasis, and 30 minutes later he experienced a sudden onset of itching urticaria over his entire body with dyspnea, palpitation, and dizziness. The patient had no recent medication history except for the praziquantel. He was diagnosed as having an anaphylactic reaction with skin eruptions induced by praziquantel. His symptoms subsided after a stomach wash and the administration of anti-anaphylactic medication in emergency department of a regional hospital in the People's Republic of China. The immediate type of hypersensitive reaction to praziquantel is plausible, and this reaction should be considered for praziquantel therapy.

[1] S. G. Brown,et al. Anaphylaxis: Clinical concepts and research priorities , 2006, Emergency medicine Australasia : EMA.

[2] N. Kabatereine,et al. Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel. , 2004, The Journal of infectious diseases.

[3] K. Hoffmann,et al. Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E , 2004, Infection and Immunity.

[4] Sung-Tae Hong,et al. Sustained-release praziquantel tablet: pharmacokinetics and the treatment of clonorchiasis in beagle dogs , 2003, Parasitology Research.

[5] J. Matsumoto. Adverse effects of praziquantel treatment of Schistosoma japonicum infection: involvement of host anaphylactic reactions induced by parasite antigen release. , 2002, International journal for parasitology.

[6] S. W. Huang. A clinical approach to a patient with praziquantel hypersensitivity. , 1992, The Journal of allergy and clinical immunology.

[7] H. Rim. The current pathobiology and chemotherapy of clonorchiasis. , 1986, Kisaengch'unghak chapchi. The Korean journal of parasitology.

[8] T. Liu. [Allergic manifestation after pyquiton treatment of schistosomiasis]. , 1984, Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases.