Recent developments in electrospray ionisation mass spectrometry: noncovalently bound protein complexes.

Covering: up to end of 2004Noncovalently bound macromolecular protein complexes constitute an essential aspect of the living cell and are responsible for many biological processes. This review focuses on the analysis of these important species by electrospray ionisation mass spectrometry. The current range of instrumentation is discussed and the major biological complexes studied to date are highlighted. This review has 108 references.

[1]  C. Robinson,et al.  Mass spectrometry of intact ribosomes , 2005, FEBS letters.

[2]  S. Akashi,et al.  Evaluation of protein-DNA binding affinity by electrospray ionization mass spectrometry , 2005, Journal of the American Society for Mass Spectrometry.

[3]  C. Robinson,et al.  The flight of macromolecular complexes in a mass spectrometer , 2005, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[4]  Evaluation of automated nano-electrospray mass spectrometry in the determination of non-covalent protein-ligand complexes. , 2004, Rapid communications in mass spectrometry : RCM.

[5]  L. Konermann,et al.  Determination of ligand-protein dissociation constants by electrospray mass spectrometry-based diffusion measurements. , 2004, Analytical chemistry.

[6]  P. Roepstorff,et al.  Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry. , 2004, Biochemistry.

[7]  Igor A Kaltashov,et al.  Indirect detection of protein-Metal binding: Interaction of serum transferrin with In3+ and Bi3+ , 2004, Journal of the American Society for Mass Spectrometry.

[8]  Derek J. Wilson,et al.  Subunit disassembly and unfolding kinetics of hemoglobin studied by time-resolved electrospray mass spectrometry. , 2004, Biochemistry.

[9]  J. Ballesta,et al.  Mass Spectrometry of Ribosomes from Saccharomyces cerevisiae , 2004, Journal of Biological Chemistry.

[10]  A. Heck,et al.  Native protein mass spectrometry: from intact oligomers to functional machineries. , 2004, Current opinion in chemical biology.

[11]  Yonghao Yu,et al.  Characterization of noncovalent protein-ligand complexes and associated enzyme intermediates of GlcNAc-6-O-sulfotransferase by electrospray ionization FT-ICR mass spectrometry , 2004, Journal of the American Society for Mass Spectrometry.

[12]  E. Williams,et al.  Further studies on the origins of asymmetric charge partitioning in protein homodimers , 2004, Journal of the American Society for Mass Spectrometry.

[13]  Albert J R Heck,et al.  Investigation of intact protein complexes by mass spectrometry. , 2004, Mass spectrometry reviews.

[14]  J. Roeraade,et al.  Influence of droplet size, capillary-cone distance and selected instrumental parameters for the analysis of noncovalent protein-ligand complexes by nano-electrospray ionization mass spectrometry. , 2004, Journal of mass spectrometry : JMS.

[15]  C. Zampronio,et al.  Production and properties of nanoelectrospray emitters used in Fourier transform ion cyclotron resonance mass spectrometry: implications for determination of association constants for noncovalent complexes. , 2004, Analytical chemistry.

[16]  Claudia S Maier,et al.  Changes in structural dynamics of the Grb2 adaptor protein upon binding of phosphotyrosine ligand to its SH2 domain. , 2004, Biochimica et biophysica acta.

[17]  S. Radford,et al.  Co-populated Conformational Ensembles of β2-Microglobulin Uncovered Quantitatively by Electrospray Ionization Mass Spectrometry* , 2004, Journal of Biological Chemistry.

[18]  D. Teller,et al.  Identification of CRALBP Ligand Interactions by Photoaffinity Labeling, Hydrogen/Deuterium Exchange, and Structural Modeling* , 2004, Journal of Biological Chemistry.

[19]  William J Griffiths,et al.  Determination of dissociation constants for protein-ligand complexes by electrospray ionization mass spectrometry. , 2004, Analytical chemistry.

[20]  R Graham Cooks,et al.  Electrosonic spray ionization. A gentle technique for generating folded proteins and protein complexes in the gas phase and for studying ion-molecule reactions at atmospheric pressure. , 2004, Analytical chemistry.

[21]  C. Robinson,et al.  Tandem mass spectrometry defines the stoichiometry and quaternary structural arrangement of tryptophan molecules in the multiprotein complex TRAP. , 2004, Journal of the American Chemical Society.

[22]  R. Morgenstern,et al.  Observation of an Intact Noncovalent Homotrimer of Detergent-solubilized Rat Microsomal Glutathione Transferase-1 by Electrospray Mass Spectrometry* , 2004, Journal of Biological Chemistry.

[23]  A. Heck,et al.  Structural Studies on Flavin Reductase PheA2 Reveal Binding of NAD in an Unusual Folded Conformation and Support Novel Mechanism of Action* , 2004, Journal of Biological Chemistry.

[24]  M. Gross,et al.  Modeling data from titration, amide H/D exchange, and mass spectrometry to obtain protein-ligand binding constants , 2004, Journal of the American Society for Mass Spectrometry.

[25]  I. Chernushevich,et al.  Collisional cooling of large ions in electrospray mass spectrometry. , 2004, Analytical chemistry.

[26]  M. Deinzer,et al.  Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry. , 2004, Biochemistry.

[27]  L. Konermann,et al.  Screening for noncovalent ligand-receptor interactions by electrospray ionization mass spectrometry-based diffusion measurements. , 2004, Analytical chemistry.

[28]  K. Breuker.  New mass spectrometric methods for the quantification of protein-ligand binding in solution. , 2004, Angewandte Chemie.

[29]  Yufen Zhao,et al.  The nature of phosphorylated chrysin-protein interactions involved in noncovalent complex formation by electrospray ionization mass spectroscopy. , 2004, Analytical chemistry.

[30]  Quantitative evaluation of noncovalent chorismate mutase-inhibitor binding by ESI-MS , 2003, Journal of the American Society for Mass Spectrometry.

[31]  F. Zsila,et al.  Electrospray mass spectrometric investigation of the binding of cis-parinaric acid to bovine beta-lactoglobulin and study of the ligand-binding site of the protein using limited proteolysis. , 2003, Rapid communications in mass spectrometry : RCM.

[32]  C. Robinson,et al.  Quaternary structure and catalytic activity of the Escherichia coli ribonuclease E amino-terminal catalytic domain. , 2003, Biochemistry.

[33]  D Lafitte,et al.  Protein-ligand and protein-protein interactions studied by electrospray ionization and mass spectrometry. , 2003, Biochemical Society transactions.

[34]  J. Klassen,et al.  Influence of solution and gas phase processes on protein-carbohydrate binding affinities determined by nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry. , 2003, Analytical chemistry.

[35]  C. Robinson,et al.  Use of a microchip device coupled with mass spectrometry for ligand screening of a multi-protein target. , 2003, Analytical chemistry.

[36]  D. Fabris,et al.  Direct mass spectrometric determination of the stoichiometry and binding affinity of the complexes between nucleocapsid protein and RNA stem-loop hairpins of the HIV-1 Psi-recognition element. , 2003, Biochemistry.

[37]  D. Peabody.  A Viral Platform for Chemical Modification and Multivalent Display , 2003, Journal of nanobiotechnology.

[38]  L. Benson,et al.  In line desalting mass spectrometry for the study of noncovalent biological complexes. , 2003, Analytical chemistry.

[39]  D. Wilson,et al.  Quantitative determination of noncovalent binding interactions using automated nanoelectrospray mass spectrometry. , 2003, Analytical chemistry.

[40]  C. Robinson,et al.  Thermal dissociation of multimeric protein complexes by using nanoelectrospray mass spectrometry. , 2003, Analytical chemistry.

[41]  F. Zal,et al.  Comparative ESI-MS study of ∼2.2 MDa native hemocyanins from deep-sea and shore crabs: from protein oligomeric state to biotope , 2003 .

[42]  S. W. Bligh,et al.  Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non‐covalent electrospray ionization mass spectrometry , 2003, Journal of molecular recognition : JMR.

[43]  L. Konermann,et al.  Diffusion measurements by electrospray mass spectrometry for studying solution-phase noncovalent interactions , 2003, Journal of the American Society for Mass Spectrometry.

[44]  COMPLX: a computer algorithm for the detection of protein-ligand and other macromolecular complexes in mass spectra. , 2003, Journal of mass spectrometry : JMS.

[45]  M. Gross,et al.  Quantification of protein-ligand interactions by mass spectrometry, titration, and H/D exchange: PLIMSTEX. , 2003, Journal of the American Chemical Society.

[46]  B. Oh,et al.  Macromolecular assembly of Helicobacter pylori urease investigated by mass spectrometry. , 2003, Journal of mass spectrometry : JMS.

[47]  R. Cooks,et al.  Amino acid clusters formed by sonic spray ionization. , 2003, Analytical chemistry.

[48]  C. Robinson,et al.  Subunit Exchange of Multimeric Protein Complexes , 2002, The Journal of Biological Chemistry.

[49]  E. Pauw,et al.  Advantages and drawbacks of nanospray for studying noncovalent protein-DNA complexes by mass spectrometry. , 2002, Rapid communications in mass spectrometry : RCM.

[50]  S. Radford,et al.  Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain , 2002, The Journal of Biological Chemistry.

[51]  Mariella Tegoni,et al.  Control of domain swapping in bovine odorant-binding protein. , 2002, The Biochemical journal.

[52]  L. Benson,et al.  Binding stoichiometry of an RNA aptamer and its transcription factor target. , 2002, Analytical biochemistry.

[53]  A. Heck,et al.  Analysis of protein-carbohydrate interaction at the lower size limit of the protein part (15-mer peptide) by NMR spectroscopy, electrospray ionization mass spectrometry, and molecular modeling. , 2002, Biochemistry.

[54]  A. Heck,et al.  Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time‐of‐flight mass spectrometry , 2002, Protein science : a publication of the Protein Society.

[55]  K. Wirtz,et al.  Determination of the stability of the noncovalent phospholipid transfer protein-lipid complex by electrospray time-of-flight mass spectrometry. , 2002, Biochemistry.

[56]  Renato Zenobi,et al.  Quantitative determination of noncovalent binding interactions using soft ionization mass spectrometry , 2002 .

[57]  C. Robinson,et al.  A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies. , 2002, Analytical chemistry.

[58]  Use of electrospray ionization mass spectrometry to study binding interactions between a replication terminator protein and DNA , 2002, Protein science : a publication of the Protein Society.

[59]  J. Langridge,et al.  A new approach for dynamics of enzyme-catalyzed glutathione conjugation by electrospray quadrupole/time-of-flight mass spectrometry. , 2001, Analytical biochemistry.

[60]  M. Karas,et al.  The influence of electrostatic interactions on the detection of heme-globin complexes in ESI-MS , 2001, Journal of the American Society for Mass Spectrometry.

[61]  L. Konermann,et al.  Electrochemically induced pH changes resulting in protein unfolding in the ion source of an electrospray mass spectrometer. , 2001, Analytical chemistry.

[62]  P Zöllner,et al.  Charge-reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses. , 2001, Journal of mass spectrometry : JMS.

[63]  P. Kitov,et al.  The observation of multivalent complexes of Shiga-like toxin with globotriaoside and the determination of their stoichiometry by nanoelectrospray Fourier-transform ion cyclotron resonance mass spectrometry. , 2001, Glycobiology.

[64]  S. Vinogradov,et al.  Observation of Large, Non-covalent Globin Subassemblies in the ∼3600 kDa Hexagonal Bilayer Hemoglobins by Electrospray Ionization Time-of-Flight Mass Spectrometry , 2001 .

[65]  A. Heck,et al.  The effect of the source pressure on the abundance of ions of noncovalent protein assemblies in an electrospray ionization orthogonal time-of-flight instrument. , 2001, Rapid communications in mass spectrometry : RCM.

[66]  L. Benson,et al.  Microelectrospray ionization analysis of noncovalent interactions within the electron transferring flavoprotein. , 2001, Biochemical and biophysical research communications.

[67]  L. Sérani,et al.  Stabilization of gas-phase noncovalent macromolecular complexes in electrospray mass spectrometry using aqueous triethylammonium bicarbonate buffer. , 2001, Analytical chemistry.

[68]  G. Siuzdak,et al.  Mass Spectrometry of an Intact Virus. , 2001, Angewandte Chemie.

[69]  R. Griffey,et al.  Analysis of noncovalent complexes of DNA and RNA by mass spectrometry. , 2001, Chemical reviews.

[70]  A. Heck,et al.  Detection of intact megaDalton protein assemblies of vanillyl‐alcohol oxidase by mass spectrometry , 2008, Protein science : a publication of the Protein Society.

[71]  C. Dobson,et al.  Observation of the noncovalent assembly and disassembly pathways of the chaperone complex MtGimC by mass spectrometry. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[72]  H. Rogniaux,et al.  Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 are confirmed by electrospray ionization-mass analysis , 2000, Journal of the American Society for Mass Spectrometry.

[73]  J. Langridge,et al.  Noncovalent associations of glutathione S-transferase and ligands: A study using electrospray quadrupole/time-of-flight mass spectrometry , 2000, Journal of the American Society for Mass Spectrometry.

[74]  C M Dobson,et al.  Detection and selective dissociation of intact ribosomes in a mass spectrometer. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[75]  L. Deterding,et al.  Molecular characterization of a tetramolecular complex between dsDNA and a DNA-binding leucine zipper peptide dimer by mass spectrometry. , 2000, Bioconjugate chemistry.

[76]  J. Hajdu,et al.  Electrospray time-of-flight mass spectrometry of the intact MS2 virus capsid , 2000 .

[77]  S. Vinogradov,et al.  Subunit Distribution of Calcium-Binding Sites in Lumbricus Terrestris Hemoglobin , 2000, Journal of protein chemistry.

[78]  A. Heck,et al.  Binding of selected carbohydrates to apo-concanavalin A studied by electrospray ionization mass spectrometry , 2000 .

[79]  L. Hanin,et al.  Electrospray Ionization Mass Spectrometric Determination of the Molecular Mass of the ∼200-kDa Globin Dodecamer Subassemblies in Hexagonal Bilayer Hemoglobins* , 1999, The Journal of Biological Chemistry.

[80]  C. Robinson,et al.  Detection of the Intact GroEL Chaperonin Assembly by Mass Spectrometry , 1999 .

[81]  C. Dobson,et al.  Mass spectrometry of ribosomes and ribosomal subunits. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[82]  I. Chernushevich,et al.  Collisional damping interface for an electrospray ionization time-of-flight mass spectrometer , 1998 .

[83]  S. Kaufman,et al.  Analysis of a 3.6-MDa hexagonal bilayer hemoglobin from Lumbricus terrestris using a gas-phase electrophoretic mobility molecular analyzer. , 1998, Analytical biochemistry.

[84]  Zhongqi Zhang,et al.  A universal algorithm for fast and automated charge state deconvolution of electrospray mass-to-charge ratio spectra , 1998, Journal of the American Society for Mass Spectrometry.

[85]  G. Siuzdak,et al.  Probing viruses with mass spectrometry. , 1998, Journal of mass spectrometry : JMS.

[86]  J. Loo,et al.  A study of Src SH2 domain protein-phosphopeptide binding interactions by electrospray ionization mass spectrometry , 1997 .

[87]  J. Loo,et al.  Studying noncovalent protein complexes by electrospray ionization mass spectrometry. , 1997, Mass spectrometry reviews.

[88]  C. Dobson,et al.  Probing the Nature of Noncovalent Interactions by Mass Spectrometry. A Study of Protein−CoA Ligand Binding and Assembly , 1996 .

[89]  S. Kaufman,et al.  Macromolecule analysis based on electrophoretic mobility in air:  globular proteins. , 1996, Analytical chemistry.

[90]  G. Whitesides,et al.  Screening derivatized peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ionization-mass spectrometry. , 1996, Journal of medicinal chemistry.

[91]  G. Siuzdak,et al.  Mass spectrometry and viral analysis. , 1996, Chemistry & biology.

[92]  A. Dell,et al.  High sensitivity collisionally-activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal-acceleration time-of-flight mass spectrometer. , 1996, Rapid communications in mass spectrometry : RCM.

[93]  M. Wilm,et al.  Analytical properties of the nanoelectrospray ion source. , 1996, Analytical chemistry.

[94]  J. Spiess,et al.  Electrospray ionization mass spectrometry of biotin binding to streptavidin , 1995, Journal of the American Society for Mass Spectrometry.

[95]  M. Wilm,et al.  Electrospray and Taylor-Cone theory, Dole's beam of macromolecules at last? , 1994 .

[96]  I. Chernushevich,et al.  Investigation of protein-protein noncovalent interactions in soybean agglutinin by electrospray ionization time-of-flight mass spectrometry. , 1994, Rapid communications in mass spectrometry : RCM.

[97]  Richard D. Smith,et al.  Observation of the noncovalent quaternary associations of proteins by electrospray ionization mass spectrometry , 1994 .

[98]  W. Ens,et al.  Reflecting time-of-flight mass spectrometer with an electrospray ion source and orthogonal extraction. , 1994, Analytical chemistry.

[99]  John Skilling,et al.  Disentangling electrospray spectra with maximum entropy , 1992 .

[100]  B. Chait,et al.  Observation of the heme-globin complex in native myoglobin by electrospray-ionization mass spectrometry , 1991 .

[101]  B. Ganem,et al.  Observation of noncovalent enzyme-substrate and enzyme-product complexes by ion-spray mass spectrometry , 1991 .

[102]  John Skilling,et al.  Maximum entropy deconvolution in electrospray mass spectrometry , 1991 .

[103]  B. Ganem,et al.  Detection of noncovalent receptor-ligand complexes by mass spectrometry , 1991 .

[104]  M. Mann,et al.  Electrospray ionization for mass spectrometry of large biomolecules. , 1989, Science.

[105]  M. Karas,et al.  Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. , 1988, Analytical chemistry.

[106]  Koichi Tanaka,et al.  Protein and polymer analyses up to m/z 100 000 by laser ionization time-of-flight mass spectrometry , 1988 .